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Acot1 Gene Detail
Summary
  • Symbol
    Acot1
  • Name
    acyl-CoA thioesterase 1
  • Synonyms
    ACH2, Cte1, CTE-1, CTE-I, D12Ucla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349396
    NCBI Gene: 26897
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84009502-84017670 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.00 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349396
protein coding gene Chr12:84009490-84018371 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019923
protein coding gene Chr12:84679728-84694238 (+)
A/J MGP_AJ_G0019880
protein coding gene Chr12:81446218-81453518 (+)
AKR/J MGP_AKRJ_G0019856
protein coding gene Chr12:83680605-83690183 (+)
BALB/cJ MGP_BALBcJ_G0019860
protein coding gene Chr12:81789376-81794346 (+)
C3H/HeJ MGP_C3HHeJ_G0019666
protein coding gene Chr12:84144112-84158823 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0017930
protein coding gene Chr12:78391442-78399751 (+)
CAST/EiJ MGP_CASTEiJ_G0019214
protein coding gene Chr12:79058730-79065237 (+)
CBA/J MGP_CBAJ_G0019637
protein coding gene Chr12:90447797-90459176 (+)
DBA/2J MGP_DBA2J_G0019752
protein coding gene Chr12:81013846-81022872 (+)
FVB/NJ MGP_FVBNJ_G0019738
protein coding gene Chr12:79965802-79974832 (+)
LP/J MGP_LPJ_G0019824
protein coding gene Chr12:84561404-84569792 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019777
protein coding gene Chr12:93417856-93426823 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0018979
protein coding gene Chr12:75497265-75507015 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018774
protein coding gene Chr12:77756862-77768161 (+)
WSB/EiJ MGP_WSBEiJ_G0019266
protein coding gene Chr12:83927507-83932779 (+)



Homology
more
  • Human Ortholog
    ACOT1, acyl-CoA thioesterase 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    ACOT1, acyl-CoA thioesterase 1
    Orthology source: HGNC
  • Synonyms
    ACH2, CTE-1, LACH2
  • Links
    NCBI Gene ID: 641371
    neXtProt AC: NX_Q86TX2
    UniProt: Q86TX2

  • Chr Location
    chr14:73493021-73543799 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26897 NCBI Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript NM_012006 RefSeq | MGI Sequence Detail 1559 C57BL/6  
polypeptide O55137 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR016662 Acyl-CoA thioesterase, long chain
    IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
    IPR029058 Alpha/Beta hydrolase fold
    IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
Molecular
Reagents
less
  • All nucleic 109
    cDNA 108
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-3361, MGI:89581
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 5
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:241351 Lu J, et al., The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep. 2017 May;18(5):841-857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory