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Tpsg1 Gene Detail
Summary
  • Symbol
    Tpsg1
  • Name
    tryptase gamma 1
  • Synonyms
    Prss31, TMT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349391
    NCBI Gene: 26945
  • Gene Overview
    MyGene.info: TPSG1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25369273-25374442 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM, cytoband A3.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349391
protein coding gene Chr17:25369216-25374442 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023354
protein coding gene Chr17:24432732-24437888 (+)
A/J MGP_AJ_G0023313
protein coding gene Chr17:23740631-23745780 (+)
AKR/J MGP_AKRJ_G0023279
protein coding gene Chr17:23840017-23845197 (+)
BALB/cJ MGP_BALBcJ_G0023318
protein coding gene Chr17:23947633-23952793 (+)
C3H/HeJ MGP_C3HHeJ_G0023078
protein coding gene Chr17:24213714-24218868 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023760
protein coding gene Chr17:25494083-25499254 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021236
protein coding gene Chr17:21202089-21207294 (+)
CAST/EiJ MGP_CASTEiJ_G0022580
protein coding gene Chr17:24082640-24087864 (+)
CBA/J MGP_CBAJ_G0023053
protein coding gene Chr17:26359152-26364312 (+)
DBA/2J MGP_DBA2J_G0023183
protein coding gene Chr17:23337284-23342471 (+)
FVB/NJ MGP_FVBNJ_G0023153
protein coding gene Chr17:23054990-23060149 (+)
LP/J MGP_LPJ_G0023260
protein coding gene Chr17:24722599-24727775 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023172
protein coding gene Chr17:26013919-26019056 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023800
protein coding gene Chr17:24126629-24131790 (+)
PWK/PhJ MGP_PWKPhJ_G0022329
protein coding gene Chr17:22091820-22097047 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022147
protein coding gene Chr17:22211406-22217402 (+)
WSB/EiJ MGP_WSBEiJ_G0022643
protein coding gene Chr17:24192510-24197647 (+)



Homology
more
  • Human Ortholog
    TPSG1, tryptase gamma 1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    TPSG1, tryptase gamma 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PRSS31, TMT, trpA
  • Links
    NCBI Gene ID: 25823
    neXtProt AC: NX_Q9NRR2
    UniProt: Q9NRR2

  • Chr Location
    16p13.3; chr16:1221651-1226454 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033200 Ensembl Gene Model | MGI Sequence Detail 5170 C57BL/6J ±  kb
transcript ENSMUST00000024999 Ensembl | MGI Sequence Detail 1186 Not Applicable  
polypeptide ENSMUSP00000024999 Ensembl | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 12
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:58140 Wong GW, et al., Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. J Biol Chem. 1999 Oct 22;274(43):30784-93
  • Latest
    J:243813 Hansbro PM, et al., Importance of mast cell Prss31/transmembrane tryptase/tryptase-gamma in lung function and experimental chronic obstructive pulmonary disease and colitis. J Biol Chem. 2014 Jun 27;289(26):18214-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory