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Pclo
Gene Detail
Symbol

Name
ID
Pclo
piccolo (presynaptic cytomatrix protein)
MGI:1349390
Synonyms
Acz, mKIAA0559, Pico
Feature Type
protein coding gene
Genetic Map
Chromosome 5
6.27 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:14514751-14863465 bp, + strand
From NCBI annotation of GRCm38

  348715 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69111  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Human
homologs
Human Homolog PCLO, piccolo presynaptic cytomatrix protein
NCBI Gene ID 27445
neXtProt AC  NX_Q9Y6V0
Human Synonyms  ACZ
Human Chr (Location)  7q11.23-q21.3; chr7:82754005-83162884 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one deletion of Pclo are viable and fertile, and display no overt abnormal phenotype. Mice homozygous for another knock-out allele exhibit some premature lethality, decreased body size, and abnormal synaptic vesicle number.
 
Interactions
Pclo interacts with 527 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cAMP-mediated signaling, cytoskeleton organization, ...
Component cell, cell junction, ...
Function calcium-dependent phospholipid binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (115)    Tissues (32)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043362 (Evidence), OTTMUSG00000043360 (Evidence)
Ensembl Gene ModelENSMUSG00000061601 (Evidence), ENSMUSG00000098239 (Evidence)
Entrez Gene26875 (Evidence)
UniGene146275
DFCITC1658470, TC1736013, TC1620148, TC1586941, TC1580620
DoTSDT.101371909, DT.40181535, DT.101371911, DT.101371910, DT.55155257, DT.94351021, DT.94329748
NIA Mouse Gene IndexU005303
Consensus CDS ProjectCCDS51415.1, CCDS59667.1
International Mouse Knockout Project StatusPclo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26875 NCBI Gene Model | MGI Sequence Detail 348715 C57BL/6J ±  kb
transcript NM_011995 RefSeq | MGI Sequence Detail 20099 C57BL/6 
polypeptide Q9QYX7 UniProt | EBI | MGI Sequence Detail 5068 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(1815 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001478 PDZ domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR008899 Zinc finger, piccolo-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000012418 protein piccolo
Graphical View of Protein Domain Structure
References
(Earliest) J:57915 Wang X, et al., Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. J Cell Biol. 1999 Oct 4;147(1):151-62
(Latest) J:205775 Regus-Leidig H, et al., Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear. PLoS One. 2013;8(8):e70373
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory