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Gcat Gene Detail
Summary
  • Symbol
    Gcat
  • Name
    glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)
  • Synonyms
    aminoacetone synthase, Kbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349389
    NCBI Gene: 26912
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79030874-79042531 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349389
protein coding gene Chr15:79030874-79042531 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022061
protein coding gene Chr15:79285801-79298154 (+)
A/J MGP_AJ_G0022022
protein coding gene Chr15:76544234-76558491 (+)
AKR/J MGP_AKRJ_G0021997
protein coding gene Chr15:78663553-78677906 (+)
BALB/cJ MGP_BALBcJ_G0022028
protein coding gene Chr15:76518251-76531338 (+)
C3H/HeJ MGP_C3HHeJ_G0021799
protein coding gene Chr15:78668146-78681733 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022471
protein coding gene Chr15:82394362-82407402 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020001
protein coding gene Chr15:73027757-73040188 (+)
CAST/EiJ MGP_CASTEiJ_G0021320
protein coding gene Chr15:79359757-79373642 (+)
CBA/J MGP_CBAJ_G0021764
protein coding gene Chr15:84947508-84963060 (+)
DBA/2J MGP_DBA2J_G0021893
protein coding gene Chr15:76024448-76037233 (+)
FVB/NJ MGP_FVBNJ_G0021871
protein coding gene Chr15:75043980-75056290 (+)
LP/J MGP_LPJ_G0021961
protein coding gene Chr15:79469860-79485691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021891
protein coding gene Chr15:90101242-90115106 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022485
protein coding gene Chr15:78689103-78701454 (+)
PWK/PhJ MGP_PWKPhJ_G0021062
protein coding gene Chr15:76029258-76042914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020899
protein coding gene Chr15:78484101-78500206 (+)
WSB/EiJ MGP_WSBEiJ_G0021372
protein coding gene Chr15:79064839-79080106 (+)



Homology
more
  • Human Ortholog
    GCAT, glycine C-acetyltransferase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GCAT, glycine C-acetyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KBL
  • Links
    NCBI Gene ID: 23464
    neXtProt AC: NX_O75600
    UniProt: O75600

  • Chr Location
    22q13.1; chr22:37807893-37817177 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    25 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Gcat
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit no gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26912 NCBI Gene Model | MGI Sequence Detail 11658 C57BL/6J ±  kb
transcript NM_013847 RefSeq | MGI Sequence Detail 2373 C57BL/6  
polypeptide O88986 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR011282 2-amino-3-ketobutyrate coenzyme A ligase
    IPR004839 Aminotransferase, class I/classII
    IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015422 Pyridoxal phosphate-dependent transferase domain 1
    IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Molecular
Reagents
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  • All nucleic 92
    cDNA 90
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146035
References
more
  • Summaries
    All 55
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:259713 Tani H, et al., Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal. Sci Rep. 2018 Jan 11;8(1):425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory