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Spag1 Gene Detail
Summary
  • Symbol
    Spag1
  • Name
    sperm associated antigen 1
  • Synonyms
    tpis, TPR-containing protein involved in spermatogenesis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349387
    NCBI Gene: 26942
  • Gene Overview
    MyGene.info: SPAG1
Location & Maps
more
  • Sequence Map
    Chr15:36179368-36235610 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56243 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 14.46 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPAG1, sperm associated antigen 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPAG1, sperm associated antigen 1
    Orthology source: HomoloGene
  • Synonyms
    CILD28, CT140, HEL-S-268, HSD-3.8, SP75, TPIS
  • Links
    NCBI Gene ID: 6674
    neXtProt AC: NX_Q07617

  • Chr Location
    8q22.2; chr8:100158003-100241904 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SPAG1 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 28; CILD28   OMIM: 615505
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Spag1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037617 Ensembl Gene Model | MGI Sequence Detail 56243 C57BL/6J ±  kb
transcript ENSMUST00000171205 Ensembl | MGI Sequence Detail 3203 Not Applicable  
polypeptide ENSMUSP00000132233 Ensembl | MGI Sequence Detail 901 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    625 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015452 sperm-associated antigen 1
  • InterPro Domains
    IPR025986 RNA-polymerase II-associated protein 3-like, C-terminal domain
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 27
    cDNA 27

    Microarray probesets 4
References
more
  • Summaries
    All 22
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:58008 Yamashita H, et al., Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J Biol Chem. 1999 Oct 15;274(42):29897-904
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory