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Spag1 Gene Detail
Summary
  • Symbol
    Spag1
  • Name
    sperm associated antigen 1
  • Synonyms
    tpis, TPR-containing protein involved in spermatogenesis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349387
    NCBI Gene: 26942
  • Gene Overview
    MyGene.info: SPAG1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36178099-36235621 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 14.46 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    625 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349387
protein coding gene Chr15:36175483-36235621 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021792
protein coding gene Chr15:34557595-34614238 (+)
A/J MGP_AJ_G0021753
protein coding gene Chr15:33260032-33314945 (+)
AKR/J MGP_AKRJ_G0021731
protein coding gene Chr15:34182057-34239805 (+)
BALB/cJ MGP_BALBcJ_G0021759
protein coding gene Chr15:33268061-33325650 (+)
C3H/HeJ MGP_C3HHeJ_G0021534
protein coding gene Chr15:34150561-34209527 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022198
protein coding gene Chr15:35864708-35920329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019736
protein coding gene Chr15:31070659-31131650 (+)
CAST/EiJ MGP_CASTEiJ_G0021050
protein coding gene Chr15:34553324-34615669 (+)
CBA/J MGP_CBAJ_G0021503
protein coding gene Chr15:37027646-37089982 (+)
DBA/2J MGP_DBA2J_G0021627
protein coding gene Chr15:33082811-33139807 (+)
FVB/NJ MGP_FVBNJ_G0021605
protein coding gene Chr15:32482587-32538424 (+)
LP/J MGP_LPJ_G0021696
protein coding gene Chr15:34461106-34521133 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021629
protein coding gene Chr15:40143662-40210806 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022221
protein coding gene Chr15:34335571-34392313 (+)
PWK/PhJ MGP_PWKPhJ_G0020794
protein coding gene Chr15:33101041-33159535 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020632
protein coding gene Chr15:34031664-34091889 (+)
WSB/EiJ MGP_WSBEiJ_G0021106
protein coding gene Chr15:34301806-34359827 (+)



Homology
more
  • Human Ortholog
    SPAG1, sperm associated antigen 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPAG1, sperm associated antigen 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD28, CT140, HEL-S-268, HSD-3.8, SP75, TPIS
  • Links
    NCBI Gene ID: 6674
    neXtProt AC: NX_Q07617
    UniProt: Q07617

  • Chr Location
    8q22.2; chr8:100157869-100241904 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SPAG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037617 Ensembl Gene Model | MGI Sequence Detail 57523 C57BL/6J ±  kb
transcript ENSMUST00000047348 Ensembl | MGI Sequence Detail 3646 Not Applicable  
polypeptide ENSMUSP00000047335 Ensembl | MGI Sequence Detail 901 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015452 sperm-associated antigen 1
  • InterPro Domains
    IPR025986 RNA-polymerase II-associated protein 3-like, C-terminal domain
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 28
    cDNA 28

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory