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Ccl21a Gene Detail
Summary
  • Symbol
    Ccl21a
  • Name
    chemokine (C-C motif) ligand 21A (serine)
  • Synonyms
    6CKBAC2, 6Ckine, ALP, CKb9, Exodus-2, Scya21, Scya21b, SLC, Tca4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349183
    NCBI Gene: 18829
  • Gene Overview
    MyGene.info: CCL21
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr4:42772860-42773991 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 22.81 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349183
protein coding gene Chr4:42772860-42773993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028185
protein coding gene Chr4:40648261-40649380 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028161
protein coding gene Chr4:39322466-39323708 (+)
C3H/HeJ MGP_C3HHeJ_G0027886
protein coding gene Chr4:40701449-40702582 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027992
protein coding gene Chr4:46791295-46792427 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026876
protein coding gene Chr4:39861632-39862714 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCL21, C-C motif chemokine ligand 21
  • Vertebrate Orthologs
    13
  • Human Ortholog
    CCL21, C-C motif chemokine ligand 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    6Ckine, CKb9, ECL, SCYA21, SLC, TCA4
  • Links
    NCBI Gene ID: 6366
    neXtProt AC: NX_O00585
    UniProt: O00585

  • Chr Location
    9p13.3; chr9:34709005-34710167 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired negative T cell selection with small thymus medulla, decreased thymic B cells and autoimmune dacryoadenitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18829 NCBI Gene Model | MGI Sequence Detail 1132 C57BL/6J ±  kb
    transcript NM_011124 RefSeq | MGI Sequence Detail 868 C57BL/6  
    polypeptide P84444 UniProt | EBI | MGI Sequence Detail 133 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 9
      Primer pair 2
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:1270157, MGI:2140627
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 18
      Gene Ontology 7
      Phenotypes 2
    • Earliest
      J:15290 Nakano H, et al., Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse. Eur J Immunol. 1993 Oct;23(10):2434-9
    • Latest
      J:257967 Wurm S, et al., CCR7 Is Important for Mesangial Cell Physiology and Repair. J Histochem Cytochem. 2018 Jan;66(1):7-22

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory