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Sdc3 Gene Detail
Summary
  • Symbol
    Sdc3
  • Name
    syndecan 3
  • Synonyms
    MGC:65603, MGC:69616, mKIAA0468, syn-3, Synd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349163
    NCBI Gene: 20970
  • Gene Overview
    MyGene.info: SDC3
  • Alliance
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130792537-130826318 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349163
protein coding gene Chr4:130792537-130826319 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028854
protein coding gene Chr4:132836882-132874429 (+)
A/J MGP_AJ_G0028813
protein coding gene Chr4:127327317-127360845 (+)
AKR/J MGP_AKRJ_G0028766
protein coding gene Chr4:130903544-130937135 (+)
BALB/cJ MGP_BALBcJ_G0028836
protein coding gene Chr4:127942609-127976912 (+)
C3H/HeJ MGP_C3HHeJ_G0028550
protein coding gene Chr4:131121863-131156764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029278
protein coding gene Chr4:137627894-137664449 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026550
protein coding gene Chr4:120431382-120464608 (+)
CAST/EiJ MGP_CASTEiJ_G0027983
protein coding gene Chr4:129164616-129202502 (+)
CBA/J MGP_CBAJ_G0028516
protein coding gene Chr4:141130435-141167534 (+)
DBA/2J MGP_DBA2J_G0028665
protein coding gene Chr4:127757541-127792918 (+)
FVB/NJ MGP_FVBNJ_G0028632
protein coding gene Chr4:126573176-126614373 (+)
LP/J MGP_LPJ_G0028766
protein coding gene Chr4:132982657-133020766 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028658
protein coding gene Chr4:145832983-145868931 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029316
protein coding gene Chr4:131277928-131315528 (+)
PWK/PhJ MGP_PWKPhJ_G0027704
protein coding gene Chr4:124394374-124428683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027530
protein coding gene Chr4:127132648-127165865 (+)
WSB/EiJ MGP_WSBEiJ_G0028063
protein coding gene Chr4:131421045-131464870 (+)



Homology
more
  • Human Ortholog
    SDC3, syndecan 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SDC3, syndecan 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SDCN, SYND3
  • Links
    NCBI Gene ID: 9672
    neXtProt AC: NX_O75056
    UniProt: O75056

  • Chr Location
    1p35.2; chr1:30869466-30909735 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SDC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced susceptibility to diet-induced obesity to a greater extent in male versus female mice. Mice heterozygous for a null allele exhibit decreased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20970 NCBI Gene Model | MGI Sequence Detail 33782 C57BL/6J ±  kb
    transcript NM_011520 RefSeq | MGI Sequence Detail 4972 Not Specified  
    polypeptide Q64519 UniProt | EBI | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 168
      cDNA 165
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14688, MGI:98465
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 17
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:31834 Sutherland AE, et al., Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo. Development. 1991 Sep;113(1):339-51
    • Latest
      J:252704 Sorrelle N, et al., From top to bottom: midkine and pleiotrophin as emerging players in immune regulation. J Leukoc Biol. 2017 Aug;102(2):277-286

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory