About   Help   FAQ
Sdc3 Gene Detail
Summary
  • Symbol
    Sdc3
  • Name
    syndecan 3
  • Synonyms
    MGC:65603, MGC:69616, mKIAA0468, syn-3, Synd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349163
    NCBI Gene: 20970
  • Alliance
    gene page
  • Transcription Start Sites
    47 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130519855-130553629 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349163
 protein coding gene Chr4:130519848-130553630 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028854
 protein coding gene Chr4:132836882-132874429 (+)
A/J MGP_AJ_G0028813
 protein coding gene Chr4:127327317-127360845 (+)
AKR/J MGP_AKRJ_G0028766
 protein coding gene Chr4:130903544-130937135 (+)
BALB/cJ MGP_BALBcJ_G0028836
 protein coding gene Chr4:127942609-127976912 (+)
C3H/HeJ MGP_C3HHeJ_G0028550
 protein coding gene Chr4:131121863-131156764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029278
 protein coding gene Chr4:137627894-137664449 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026550
 protein coding gene Chr4:120431382-120464608 (+)
CAST/EiJ MGP_CASTEiJ_G0027983
 protein coding gene Chr4:129164616-129202502 (+)
CBA/J MGP_CBAJ_G0028516
 protein coding gene Chr4:141130435-141167534 (+)
DBA/2J MGP_DBA2J_G0028665
 protein coding gene Chr4:127757541-127792918 (+)
FVB/NJ MGP_FVBNJ_G0028632
 protein coding gene Chr4:126573176-126614373 (+)
LP/J MGP_LPJ_G0028766
 protein coding gene Chr4:132982657-133020766 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028658
 protein coding gene Chr4:145832983-145868931 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029316
 protein coding gene Chr4:131277928-131315528 (+)
PWK/PhJ MGP_PWKPhJ_G0027704
 protein coding gene Chr4:124394374-124428683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027530
 protein coding gene Chr4:127132648-127165865 (+)
WSB/EiJ MGP_WSBEiJ_G0028063
 protein coding gene Chr4:131421045-131464870 (+)



Homology
more
  • Human Ortholog
    SDC3, syndecan 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDC3, syndecan 3
  • Synonyms
    SDCN, SYND3
  • Links
    NCBI Gene ID: 9672
    UniProt: O75056

  • Chr Location
    1p35.2; chr1:30869466-30909735 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SDC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced susceptibility to diet-induced obesity to a greater extent in male versus female mice. Mice heterozygous for a null allele exhibit decreased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    41
  • cDNA Data
    164
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20970 NCBI Gene Model | MGI Sequence Detail 33775 C57BL/6J ±  kb
    transcript NM_001424879 RefSeq | MGI Sequence Detail 5107 C57BL/6  
    polypeptide Q64519 UniProt | EBI | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 170
      cDNA 165
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14688, MGI:98465
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:31834 Sutherland AE, et al., Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo. Development. 1991 Sep;113(1):339-51
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/07/2025
    MGI 6.24     		The Jackson Laboratory