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Sdc1
Gene Detail
 Symbol
Name
ID
Sdc1
syndecan 1
MGI:1349162
STS D12Mit104
Synonyms CD138, syn-1, Synd, Synd1
Feature Type protein coding gene
Genetic Map
Chromosome 12
3.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr12:8771323-8793715 bp, + strand
From VEGA annotation of GRCm38

  22393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: syndecan-1
Gene Tree: Sdc1

Human
homologs
Human Homolog SDC1, syndecan 1
NCBI Gene ID 6382
neXtProt AC  NX_P18827
Human Synonyms  CD138, SDC, SYND1, syndecan
Human Chr (Location)  2p24.1; chr2:20200797-20225433 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Targeted mutant mice are overtly normal but resist mammary tumor development in response to Wnt1, and show delayed cutaneous and corneal wound healing, defective leukocyte adhesion to endothelia, increased angiogenesis, as well as reduced susceptibility to P. aeruginosa lung infection.
 
Interactions
Sdc1 interacts with 269 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process canonical Wnt signaling pathway, inflammatory response, ...
Component cell surface, cytoplasm, ...
Function cytoskeletal protein binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (160)    Tissues (88)    Images (67)
Theiler Stages: 7, 9, 10, 11, 12, 13, 15, 16, 17, 19, 20, 21, 23, 26, 28
Assay TypeResults
Immunohistochemistry 97
RNA in situ 52
Northern blot 4
RT-PCR 1
RNase protection 6
cDNA source data(307)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(317) Genomic(6) cDNA(309) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000033390 (Evidence)
Ensembl Gene ModelENSMUSG00000020592 (Evidence)
Entrez Gene20969 (Evidence)
UniGene2580
DFCITC1573321, TC1633059
DoTSDT.494284, DT.97384342, DT.97384343
NIA Mouse Gene IndexU013744
Consensus CDS ProjectCCDS25803.1
International Mouse Knockout Project StatusSdc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033390 VEGA Gene Model | MGI Sequence Detail 22393 C57BL/6J ±  kb
transcript OTTMUST00000083825 VEGA | MGI Sequence Detail 3157 Not Applicable 
polypeptide OTTMUSP00000045098 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003585 Neurexin/syndecan/glycophorin C
InterPro IPR001050 Syndecan
Protein Ontology PR:000001935 syndecan-1
References (Earliest) J:9669 Saunders S, et al., Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989 Apr;108(4):1547-56
(Latest) J:212433 Voyvodic PL, et al., Loss of syndecan-1 induces a pro-inflammatory phenotype in endothelial cells with a dysregulated response to atheroprotective flow. J Biol Chem. 2014 Apr 4;289(14):9547-59
All references(157)
Other
accession IDs
MGD-MRK-14682, MGD-MRK-14686, MGI:2144723, MGI:2144725, MGI:98464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory