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Sdc1 Gene Detail
Summary
  • Symbol
    Sdc1
  • Name
    syndecan 1
  • Synonyms
    CD138, syn-1, Synd, Synd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349162
    NCBI Gene: 20969
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8821396-8843716 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.94 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349162
protein coding gene Chr12:8821323-8843716 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019588
protein coding gene Chr12:5840952-5863718 (+)
A/J MGP_AJ_G0019555
protein coding gene Chr12:5678830-5701588 (+)
AKR/J MGP_AKRJ_G0019525
protein coding gene Chr12:6059828-6082837 (+)
BALB/cJ MGP_BALBcJ_G0019530
protein coding gene Chr12:5804509-5827773 (+)
C3H/HeJ MGP_C3HHeJ_G0019336
protein coding gene Chr12:5889125-5912988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019979
protein coding gene Chr12:6021992-6046481 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017604
protein coding gene Chr12:5489050-5511933 (+)
CAST/EiJ MGP_CASTEiJ_G0018891
protein coding gene Chr12:5882347-5903196 (+)
CBA/J MGP_CBAJ_G0019307
protein coding gene Chr12:6554006-6576389 (+)
DBA/2J MGP_DBA2J_G0019420
protein coding gene Chr12:5633869-5655998 (+)
FVB/NJ MGP_FVBNJ_G0019411
protein coding gene Chr12:5604177-5626083 (+)
LP/J MGP_LPJ_G0019491
protein coding gene Chr12:5888696-5912875 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019444
protein coding gene Chr12:6366603-6391578 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020018
protein coding gene Chr12:5796722-5817574 (+)
PWK/PhJ MGP_PWKPhJ_G0018657
protein coding gene Chr12:5699294-5720088 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018448
protein coding gene Chr12:5811739-5835461 (+)
WSB/EiJ MGP_WSBEiJ_G0018942
protein coding gene Chr12:5862002-5882786 (+)



Homology
more
  • Human Ortholog
    SDC1, syndecan 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDC1, syndecan 1
  • Synonyms
    CD138, SDC, SYND1, syndecan
  • Links
    NCBI Gene ID: 6382
    neXtProt AC: NX_P18827
    UniProt: P18827

  • Chr Location
    2p24.1; chr2:20200797-20225475 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutant mice are overtly normal but resist mammary tumor development in response to Wnt1, and show delayed cutaneous and corneal wound healing, defective leukocyte adhesion to endothelia, increased angiogenesis, as well as reduced susceptibility to P. aeruginosa lung infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20969 NCBI Gene Model | MGI Sequence Detail 22321 C57BL/6J ±  kb
    transcript NM_011519 RefSeq | MGI Sequence Detail 3057 ZRU/MplStud  
    polypeptide P18828 UniProt | EBI | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 325
      Genomic 6
      cDNA 313
      Primer pair 3
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14682, MGD-MRK-14686, MGI:2144723, MGI:2144725, MGI:98464
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 56
      Gene Ontology 12
      Phenotypes 78
    • Earliest
      J:9669 Saunders S, et al., Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989 Apr;108(4):1547-56
    • Latest
      J:344490 Inoue T, et al., Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees. J Exp Med. 2023 Feb 6;220(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory