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Sdc1
Gene Detail
Symbol

Name
ID
Sdc1
syndecan 1
MGI:1349162
STS
Synonyms
CD138, syn-1, Synd, Synd1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
3.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr12:8771323-8793715 bp, + strand
From VEGA annotation of GRCm38

  22393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: SDC1
Protein SuperFamily: syndecan-1
Gene Tree: Sdc1

Human
homologs
SDC1, syndecan 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6382
neXtProt AC: NX_P18827

Human Synonyms: CD138, SDC, SYND1, syndecan

Human Chr (Location): 2p24.1; chr2:20200797-20225433 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF , CvDC )
 
Targeted mutant mice are overtly normal but resist mammary tumor development in response to Wnt1, and show delayed cutaneous and corneal wound healing, defective leukocyte adhesion to endothelia, increased angiogenesis, as well as reduced susceptibility to P. aeruginosa lung infection.
 
Interactions
Sdc1 interacts with 269 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process canonical Wnt signaling pathway, cell migration, ...
Component cell surface, cytoplasm, ...
Function glycoprotein binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (162)    Tissues (89)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 99
RNA in situ 52
Northern blot 4
RT-PCR 1
RNase protection 6
cDNA source data(307)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sdc1    NEW 
Molecular
reagents
All nucleic(317) Genomic(6) cDNA(309) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000033390 (Evidence)
Ensembl Gene Model ENSMUSG00000020592 (Evidence)
Entrez Gene 20969 (Evidence)
UniGene 2580
DFCI TC1573321, TC1633059
DoTS DT.494284, DT.97384342, DT.97384343
NIA Mouse Gene Index U013744
Consensus CDS Project CCDS25803.1
International Mouse Phenotyping Consortium Status Sdc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033390 VEGA Gene Model | MGI Sequence Detail 22393 C57BL/6J ±  kb
transcript OTTMUST00000083825 VEGA | MGI Sequence Detail 3157 Not Applicable 
polypeptide OTTMUSP00000045098 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003585 Neurexin/syndecan/glycophorin C
InterPro IPR001050 Syndecan
Protein Ontology PR:000001935 syndecan-1
References
(Earliest) J:9669 Saunders S, et al., Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989 Apr;108(4):1547-56
(Latest) J:214479 Chaterji S, et al., Syndecan-1 regulates vascular smooth muscle cell phenotype. PLoS One. 2014;9(2):e89824
All references(155)
Other
accession IDs
MGD-MRK-14682, MGD-MRK-14686, MGI:2144723, MGI:2144725, MGI:98464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory