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Tsks Gene Detail
Summary
  • Symbol
    Tsks
  • Name
    testis-specific serine kinase substrate
  • Synonyms
    clone 4, Stk22s1, Tsks, Tssks1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347560
    NCBI Gene: 22116
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44592628-44607459 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.07 cM
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347560
 protein coding gene Chr7:44579044-44607465 (+)
129S1/SvImJ ENSMUSG00200022831
 protein coding gene Chr7:32188387-32204465 (+)
A/J ENSMUSG00195038285
 protein coding gene Chr7:36216456-36232533 (+)
AKR/J ENSMUSG00220007423
 protein coding gene Chr7:30521423-30537500 (+)
BALB/cJ ENSMUSG00180037217
 protein coding gene Chr7:33091857-33107935 (+)
C3H/HeJ ENSMUSG00175032286
 protein coding gene Chr7:33624316-33640394 (+)
C57BL/6NJ ENSMUSG00215044245
 protein coding gene Chr7:32885413-32900229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029684
 protein coding gene Chr7:46879011-46894347 (+)
CAST/EiJ ENSTCUG00005041379
 protein coding gene Chr7:36600464-36616569 (+)
CBA/J ENSMUSG00210048834
 protein coding gene Chr7:33995676-34011753 (+)
DBA/2J ENSMUSG00185046154
 protein coding gene Chr7:37868303-37884380 (+)
FVB/NJ ENSMUSG00205024086
 protein coding gene Chr7:33540941-33555754 (+)
JF1/MsJ ENSUMUG00000025064
 protein coding gene Chr7:42355568-42371685 (+)
LP/J ENSMUSG00230051595
 protein coding gene Chr7:43297708-43312529 (+)
NOD/ShiLtJ ENSMUSG00190030413
 protein coding gene Chr7:33868700-33883513 (+)
NZO/HlLtJ ENSMUSG00225015402
 protein coding gene Chr7:41506305-41521118 (+)
PWK/PhJ ENSLUMG00010040707
 protein coding gene Chr7:32823804-32839929 (+)
SPRET/EiJ ENSMSPG00010041985
 protein coding gene Chr7:32600203-32616298 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TSKS, testis specific serine kinase substrate
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSKS, testis specific serine kinase substrate
  • Synonyms
    PPP1R161, STK22S1, TSKS1, TSSKS
  • Links
    NCBI Gene ID: 60385
    UniProt: Q9UJT2

  • Chr Location
    19q13.33; chr19:49739753-49763306 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male sterility, low sperm motility, abnormalities in sperm head, midpiece and mitochondrial sheath morphology, and a spermiation defect associated with impaired elimination of spermatid cytoplasm, excess residual cytoplasm, and increased apoptosis in spermatozoa.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    21
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059891 Ensembl Gene Model | MGI Sequence Detail 14832 C57BL/6J ±  kb
    transcript ENSMUST00000120929 Ensembl | MGI Sequence Detail 1843 Not Applicable  
    polypeptide ENSMUSP00000112673 Ensembl | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196618
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:45029 Kueng P, et al., A novel family of serine/threonine kinases participating in spermiogenesis. J Cell Biol. 1997 Dec 29;139(7):1851-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory