About   Help   FAQ
Tssk2
Gene Detail
 Symbol
Name
ID
Tssk2
testis-specific serine kinase 2
MGI:1347559
Synonyms DGS-G, SPOGA2, Stk22b, Tsk2
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:17898637-17900023 bp, + strand
From Ensembl annotation of GRCm38

  1387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31512  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: testis-specific serine/threonine-protein kinase
Gene Tree: Tssk2

Human
homologs
Human Homolog TSSK2, testis-specific serine kinase 2
NCBI Gene ID 23617
neXtProt AC  NX_Q96PF2
Human Synonyms  DGS-G, SPOGA2, STK22B, TSK2
Human Chr (Location)  22q11.21; chr22:19130808-19132623 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Tssk2 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Tssk2 interacts with 85 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell differentiation, multicellular organismal development, ...
Component acrosomal vesicle, centriole, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (33)    Tissues (30)    Images (4)
Theiler Stages: 16, 17, 20, 22, 26, 27, 28
Assay TypeResults
RT-PCR 33
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(10) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000045521 (Evidence)
Entrez Gene22115 (Evidence)
UniGene310201
DFCITC1584992
DoTSDT.526391
NIA Mouse Gene IndexU043989
EC2.7.11.1
Consensus CDS ProjectCCDS28012.1
International Mouse Knockout Project StatusTssk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045521 Ensembl Gene Model | MGI Sequence Detail 1387 C57BL/6J ±  kb
transcript ENSMUST00000055374 Ensembl | MGI Sequence Detail 1387 Not Applicable 
polypeptide ENSMUSP00000051035 Ensembl | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016771 testis-specific serine/threonine-protein kinase 2
References (Earliest) J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
(Latest) J:175334 Li Y, et al., Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Mol Hum Reprod. 2011 Jan;17(1):42-56
All references(37)
Other
accession IDs
MGI:892906

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory