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Tssk2 Gene Detail
Summary
  • Symbol
    Tssk2
  • Name
    testis-specific serine kinase 2
  • Synonyms
    DGS-G, SPOGA2, Stk22b, Tsk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347559
    NCBI Gene: 22115
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17716501-17717888 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.09 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347559
protein coding gene Chr16:17716501-17717888 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022596
protein coding gene Chr16:15085513-15086899 (+)
A/J MGP_AJ_G0022557
protein coding gene Chr16:14334323-14335709 (+)
AKR/J MGP_AKRJ_G0022534
protein coding gene Chr16:14893998-14895384 (+)
BALB/cJ MGP_BALBcJ_G0022560
protein coding gene Chr16:14487447-14488833 (+)
C3H/HeJ MGP_C3HHeJ_G0022327
protein coding gene Chr16:15040580-15041966 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023011
protein coding gene Chr16:15327763-15329149 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020531
protein coding gene Chr16:14392529-14393935 (+)
CAST/EiJ MGP_CASTEiJ_G0021855
protein coding gene Chr16:14957107-14958493 (+)
CBA/J MGP_CBAJ_G0022298
protein coding gene Chr16:16001157-16002543 (+)
DBA/2J MGP_DBA2J_G0022428
protein coding gene Chr16:14246637-14248023 (+)
FVB/NJ MGP_FVBNJ_G0022404
protein coding gene Chr16:14296740-14298190 (+)
LP/J MGP_LPJ_G0022495
protein coding gene Chr16:14868929-14870315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022425
protein coding gene Chr16:15680078-15681464 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023022
protein coding gene Chr16:14839388-14840774 (+)
PWK/PhJ MGP_PWKPhJ_G0021598
protein coding gene Chr16:14505535-14506921 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021426
protein coding gene Chr16:14808711-14810097 (+)
WSB/EiJ MGP_WSBEiJ_G0021902
protein coding gene Chr16:14823762-14825148 (+)



Homology
more
  • Human Ortholog
    TSSK2, testis specific serine kinase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSSK2, testis specific serine kinase 2
  • Synonyms
    DGS-G, SPOGA2, STK22B, TSK2
  • Links
    NCBI Gene ID: 23617
    neXtProt AC: NX_Q96PF2
    UniProt: Q96PF2

  • Chr Location
    22q11.21; chr22:19131308-19132622 (+)  GRCh38

Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotype references
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22115 NCBI Gene Model | MGI Sequence Detail 1388 C57BL/6J ±  kb
transcript NM_009436 RefSeq | MGI Sequence Detail 1403 ZRU/MplStud  
polypeptide O54863 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    Genomic 10
    cDNA 20
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:892906
References
more
  • Summaries
    All 84
    Developmental Gene Expression 4
    Diseases 4
    Gene Ontology 8
    Phenotypes 52
  • Earliest
    J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
  • Latest
    J:342597 Rummell BP, et al., Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition. Nat Commun. 2023 Nov 15;14(1):7388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory