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Tssk1
Gene Detail
Symbol

Name
ID
Tssk1
testis-specific serine kinase 1
MGI:1347557
Synonyms
Stk22a, Tsk1, TSK-1, Tssk
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr16:17894223-17897922 bp, + strand
From VEGA annotation of GRCm38

  3700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TSSK1A, TSSK1B
Protein SuperFamily: testis-specific serine/threonine-protein kinase
Gene Tree: Tssk1

Human
homologs
TSSK1A, testis-specific serine kinase 1A pseudogene
Orthology source: HGNC

IDs:
NCBI Gene ID: 23752

Human Synonyms: SPOGA1, STK22A, TSSK1, TSSK1b, TSSK7P

Human Chr (Location): 22q11.21; chr22:19124918-19125867 (+)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Tssk1 (7)
 
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Tssk1 interacts with 54 markers (Mir16-2, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, intracellular signal transduction, ...
Component acrosomal vesicle, cell projection, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (37)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
Northern blot 6
Western blot 6
RT-PCR 33
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(14) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050075 (Evidence)
Ensembl Gene Model ENSMUSG00000041566 (Evidence)
Entrez Gene 22114 (Evidence)
UniGene 439725
DFCI TC1620794, TC1583193
DoTS DT.103573594, DT.483571
EC 2.7.11.1
Consensus CDS Project CCDS28011.1
International Mouse Phenotyping Consortium Status Tssk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050075 VEGA Gene Model | MGI Sequence Detail 3700 C57BL/6J ±  kb
transcript OTTMUST00000127356 VEGA | MGI Sequence Detail 3700 Not Applicable 
polypeptide OTTMUSP00000068726 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016770 testis-specific serine/threonine-protein kinase 1
References
(Earliest) J:17004 Bielke W, et al., Characterization of a novel murine testis-specific serine/threonine kinase. Gene. 1994 Feb 25;139(2):235-9
(Latest) J:204598 MacLeod G, et al., PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis. Reproduction. 2014 Jan;147(1):1-12
All references(44)
Other
accession IDs
MGD-MRK-16319, MGI:99541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory