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Tssk1
Gene Detail
 Symbol
Name
ID
Tssk1
testis-specific serine kinase 1
MGI:1347557
Synonyms Stk22a, Tsk1, TSK-1, Tssk
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr16:17894203-17895651 bp, + strand
From Ensembl annotation of GRCm38

  1449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: testis-specific serine/threonine-protein kinase
Gene Tree: Tssk1

Human
homologs
Human Homolog TSSK1B, testis-specific serine kinase 1B
NCBI Gene ID 83942
neXtProt AC  NX_Q9BXA7
Human Synonyms  SPOGA4, STK22D, TSK1, TSSK1
Human Chr (Location)  5q22.2; chr5:113432554-113435031 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, multicellular organismal development, ...
Component acrosomal vesicle, cell projection, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (33)    Tissues (29)    Images (4)
Theiler Stages: 16, 17, 20, 22, 26, 28
Assay TypeResults
RT-PCR 33
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) Genomic(14) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000041566 (Evidence)
Entrez Gene22114 (Evidence)
UniGene439725
DFCITC1583193, TC1620794
DoTSDT.103573594, DT.483571
EC2.7.11.1
Consensus CDS ProjectCCDS28011.1
International Mouse Knockout Project StatusTssk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041566 Ensembl Gene Model | MGI Sequence Detail 1449 C57BL/6J ±  kb
transcript ENSMUST00000046937 Ensembl | MGI Sequence Detail 1449 Not Applicable 
polypeptide ENSMUSP00000040302 Ensembl | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016770 testis-specific serine/threonine-protein kinase 1
References (Earliest) J:17004 Bielke W, et al., Characterization of a novel murine testis-specific serine/threonine kinase. Gene. 1994 Feb 25;139(2):235-9
(Latest) J:175334 Li Y, et al., Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Mol Hum Reprod. 2011 Jan;17(1):42-56
All references(42)
Other
accession IDs
MGD-MRK-16319, MGI:99541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory