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Tssk1 Gene Detail
Summary
  • Symbol
    Tssk1
  • Name
    testis-specific serine kinase 1
  • Synonyms
    Stk22a, Tsk1, TSK-1, Tssk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347557
    NCBI Gene: 22114
Location & Maps
more
  • Sequence Map
    Chr16:17894223-17897922 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3700 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TSSK1A, testis specific serine kinase 1A, pseudogene
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TSSK1A, testis specific serine kinase 1A, pseudogene
    Orthology source: HGNC
  • Synonyms
    SPOGA1, STK22A, TSSK1, TSSK1AP, TSSK1b, TSSK7P
  • Links
    NCBI Gene ID: 23752

  • Chr Location
    22q11.21; chr22:19124918-19125867 (+)  GRCh38.p2

  • Human Ortholog
    TSSK1B, testis specific serine kinase 1B
    Orthology source: HomoloGene
  • Synonyms
    FKSG81, SPOGA4, STK22D, TSK1, TSSK1
  • Links
    NCBI Gene ID: 83942
    neXtProt AC: NX_Q9BXA7

  • Chr Location
    5q22.2; chr5:113432554-113435031 (-)  GRCh38.p2

Human Diseases
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  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    10
  • Targeted
    10
  • Genomic Mutations
    7 involving Tssk1
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050075 VEGA Gene Model | MGI Sequence Detail 3700 C57BL/6J ±  kb
transcript OTTMUST00000127356 VEGA | MGI Sequence Detail 3700 Not Applicable  
polypeptide OTTMUSP00000068726 VEGA | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016770 testis-specific serine/threonine-protein kinase 1
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 36
    Genomic 14
    cDNA 18
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16319, MGI:99541
References
more
  • Summaries
    All 42
    Developmental Gene Expression 6
    Diseases 8
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:17004 Bielke W, et al., Characterization of a novel murine testis-specific serine/threonine kinase. Gene. 1994 Feb 25;139(2):235-9
  • Latest
    J:204598 MacLeod G, et al., PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis. Reproduction. 2014 Jan;147(1):1-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory