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Tssk1
Gene Detail
Symbol

Name
ID
Tssk1
testis-specific serine kinase 1
MGI:1347557
Synonyms
Stk22a, Tsk1, TSK-1, Tssk
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr16:17894223-17897922 bp, + strand
From VEGA annotation of GRCm38

  3700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: testis-specific serine/threonine-protein kinase
Gene Tree: Tssk1

Human
homologs
Human Homolog   TSSK1B, testis-specific serine kinase 1B
NCBI Gene ID 83942
neXtProt AC  NX_Q9BXA7
Human Synonyms  FKSG81, SPOGA4, STK22D, TSK1, TSSK1
Human Chr (Location)  5q22.2; chr5:113432554-113435031 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Tssk1 (7)
 
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Tssk1 interacts with 54 markers (Mir16-2, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell differentiation, intracellular signal transduction, ...
Component acrosomal vesicle, cell projection, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (37)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
Northern blot 6
Western blot 6
RT-PCR 33
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(14) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000050075 (Evidence)
Ensembl Gene ModelENSMUSG00000041566 (Evidence)
Entrez Gene22114 (Evidence)
UniGene439725
DFCITC1583193, TC1620794
DoTSDT.483571, DT.103573594
EC2.7.11.1
Consensus CDS ProjectCCDS28011.1
International Mouse Knockout Project StatusTssk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050075 VEGA Gene Model | MGI Sequence Detail 3700 C57BL/6J ±  kb
transcript OTTMUST00000127356 VEGA | MGI Sequence Detail 3700 Not Applicable 
polypeptide OTTMUSP00000068726 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000016770 testis-specific serine/threonine-protein kinase 1
References
(Earliest) J:17004 Bielke W, et al., Characterization of a novel murine testis-specific serine/threonine kinase. Gene. 1994 Feb 25;139(2):235-9
(Latest) J:204598 MacLeod G, et al., PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis. Reproduction. 2014 Jan;147(1):1-12
All references(45)
Other
accession IDs
MGD-MRK-16319, MGI:99541

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory