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Pla2g10
Gene Detail
 Symbol
Name
ID
Pla2g10
phospholipase A2, group X
MGI:1347522
Synonyms GX sPLA2, mGXsPLA2, PLA2GX
Feature Type protein coding gene
Genetic Map
Chromosome 16
9.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:13715057-13730983 bp, - strand
From VEGA annotation of GRCm38

  15927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g10

Human
homologs
Human Homolog PLA2G10, phospholipase A2, group X
NCBI Gene ID 8399
neXtProt AC  NX_O15496
Human Synonyms  GXPLA2, GXSPLA2, SPLA2
Human Chr (Location)  16p13.1-p12; chr16:14672548-14702763 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(45) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion.
 
Interactions
Pla2g10 interacts with 93 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process axon guidance, cholesterol homeostasis, ...
Component extracellular region
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (102)    Images (6)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
Northern blot 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026305 (Evidence)
Ensembl Gene ModelENSMUSG00000022683 (Evidence)
Entrez Gene26565 (Evidence)
UniGene4214
DFCITC1586537, TC1595662
DoTSDT.526565, DT.91336148
NIA Mouse Gene IndexU036803
EC3.1.1.4
Consensus CDS ProjectCCDS27967.1, CCDS70684.1
International Mouse Knockout Project StatusPla2g10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026305 VEGA Gene Model | MGI Sequence Detail 15927 C57BL/6J ±  kb
transcript OTTMUST00000065065 VEGA | MGI Sequence Detail 1423 Not Applicable 
polypeptide OTTMUSP00000032376 VEGA | MGI Sequence Detail 151 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(7) UniProt(4)
Polymorphisms SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001211 Phospholipase A2
InterPro IPR013090 Phospholipase A2, active site
InterPro IPR016090 Phospholipase A2 domain
Protein Ontology PR:000012795 group 10 secretory phospholipase A2
References (Earliest) J:41210 Cupillard L, et al., Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. J Biol Chem. 1997 Jun 20;272(25):15745-52
(Latest) J:197334 Taketomi Y, et al., Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol. 2013 Jun;14(6):554-63
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory