Pla2g10
Gene Detail

Symbol Name ID

Pla2g10 phospholipase A2, group X MGI:1347522

Synonyms

GX sPLA2, mGXsPLA2, PLA2GX

Feature Type

protein coding gene

Genetic Map

Chromosome 16

9.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:13715057-13730983 bp, - strand From VEGA annotation of GRCm38   15927 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g10

Human homologs

Human Homolog		PLA2G10, phospholipase A2, group X
NCBI Gene ID		8399
neXtProt AC		NX_O15496
Human Synonyms		GXPLA2, GXSPLA2, SPLA2
Human Chr (Location)		16p13.1-p12; chr16:14766405-14788526 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(51) : Targeted(6) Gene trapped(45)
 

Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	axon guidance, cholesterol homeostasis, ...
Component	extracellular region
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (102)    Images (6)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	8

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026305 (Evidence)
Ensembl Gene Model	ENSMUSG00000022683 (Evidence)
Entrez Gene	26565 (Evidence)
UniGene	4214
DFCI	TC1586537, TC1595662
DoTS	DT.526565, DT.91336148
NIA Mouse Gene Index	U036803
EC	3.1.1.4
Consensus CDS Project	CCDS27967.1
International Mouse Knockout Project Status	Pla2g10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026305	VEGA Gene Model | MGI Sequence Detail	15927	C57BL/6J
transcript	OTTMUST00000065065	VEGA | MGI Sequence Detail	1423	Not Applicable
polypeptide	OTTMUSP00000032376	VEGA | MGI Sequence Detail	151	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001211	Phospholipase A2
InterPro	IPR013090	Phospholipase A2, active site
InterPro	IPR016090	Phospholipase A2 domain
Protein Ontology	PR:000012795	group 10 secretory phospholipase A2

References

(Earliest) J:41210 Cupillard L, et al., Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. J Biol Chem. 1997 Jun 20;272(25):15745-52
(Latest) J:181585 Watanabe K, et al., Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice. Am J Physiol Heart Circ Physiol. 2012 Jan;302(1):H95-104
All references(50)