About   Help   FAQ
Pla2g10
Gene Detail
Symbol

Name
ID
Pla2g10
phospholipase A2, group X
MGI:1347522
Synonyms
GX sPLA2, mGXsPLA2, PLA2GX
Feature Type
protein coding gene
Genetic Map
Chromosome 16
9.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:13715057-13730983 bp, - strand
From VEGA annotation of GRCm38

  15927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2636  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLA2G10
Protein SuperFamily: phospholipase A2
Gene Tree: Pla2g10

Human
homologs
PLA2G10, phospholipase A2, group X
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8399
neXtProt AC: NX_O15496

Human Synonyms: GXPLA2, GXSPLA2, SPLA2

Human Chr (Location): 16p13.1-p12; chr16:14672548-14694669 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(45) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion.
 
Interactions
Pla2g10 interacts with 93 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process axon guidance, cholesterol homeostasis, ...
Component extracellular region
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (102)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 8
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026305 (Evidence)
Ensembl Gene Model ENSMUSG00000022683 (Evidence)
Entrez Gene 26565 (Evidence)
UniGene 4214
DFCI TC1586537, TC1595662
DoTS DT.91336148, DT.526565
NIA Mouse Gene Index U036803
EC 3.1.1.4
Consensus CDS Project CCDS27967.1, CCDS70684.1
International Mouse Phenotyping Consortium Status Pla2g10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026305 VEGA Gene Model | MGI Sequence Detail 15927 C57BL/6J ±  kb
transcript OTTMUST00000065065 VEGA | MGI Sequence Detail 1423 Not Applicable 
polypeptide OTTMUSP00000032376 VEGA | MGI Sequence Detail 151 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001211 Phospholipase A2
InterPro IPR013090 Phospholipase A2, active site
InterPro IPR016090 Phospholipase A2 domain
Protein Ontology PR:000012795 group 10 secretory phospholipase A2
References
(Earliest) J:58155 Valentin E, et al., On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. J Biol Chem. 1999 Oct 29;274(44):31195-202
(Latest) J:216868 Shridas P, et al., Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. J Biol Chem. 2014 Oct 3;289(40):27410-7
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory