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Foxk1
Gene Detail
Symbol

Name
ID
Foxk1
forkhead box K1
MGI:1347488
Synonyms
A630048H08Rik, Mnf
Feature Type
protein coding gene
Genetic Map
Chromosome 5
81.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:142401497-142462011 bp, + strand
From VEGA annotation of GRCm38

  60515 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:82414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: FOXK1
Gene Tree: Foxk1

Human
homologs
FOXK1, forkhead box K1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 221937
neXtProt AC: NX_P85037

Human Synonyms: FOXK1L

Human Chr (Location): 7p22.1; chr7:4644691-4771443 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(22) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Foxk1 interacts with 379 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process anatomical structure morphogenesis, cell differentiation, ...
Component nucleolus, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (154)    Tissues (119)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 115
RT-PCR 33
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN foxk1    NEW 
Molecular
reagents
All nucleic(23) cDNA(17) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000054857 (Evidence)
Ensembl Gene Model ENSMUSG00000056493 (Evidence)
Entrez Gene 17425 (Evidence)
DFCI TC1580112, TC1602071, TC1604631
PDB 2A3S, 2D2W
Consensus CDS Project CCDS19826.1
International Mouse Phenotyping Consortium Status Foxk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054857 VEGA Gene Model | MGI Sequence Detail 60515 C57BL/6J ±  kb
transcript OTTMUST00000135930 VEGA | MGI Sequence Detail 7439 Not Applicable 
polypeptide OTTMUSP00000071847 VEGA | MGI Sequence Detail 719 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(5) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR001766 Fork head domain
InterPro IPR018122 Fork head domain conserved site1
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007631 forkhead box protein K1
References
(Earliest) J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
(Latest) J:199180 Sel S, et al., The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina. Gene Expr Patterns. 2013 Oct;13(7):280-6
All references(54)
Other
accession IDs
MGD-MRK-12338, MGI:2140907, MGI:97042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory