About   Help   FAQ
Foxk1
Gene Detail
 Symbol
Name
ID
Foxk1
forkhead box K1
MGI:1347488
Synonyms A630048H08Rik, Mnf
Feature Type protein coding gene
Genetic Map
Chromosome 5
81.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:142401497-142462014 bp, + strand
From Ensembl annotation of GRCm38

  60518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:82414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxk1

Human
homologs
Human Homolog FOXK1, forkhead box K1
NCBI Gene ID 221937
neXtProt AC  NX_P85037
Human Synonyms  FOXK1L
Human Chr (Location)  7p22.1; chr7:4682299-4771443 (+)  GRCh38
Alleles
and
phenotypes
All alleles(23) : Gene trapped(22) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (161)    Tissues (114)    Images (34)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 115
RT-PCR 40
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(17) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000056493 (Evidence)
Entrez Gene17425 (Evidence)
DFCITC1580112, TC1602071, TC1604631
PDB2A3S, 2D2W
Consensus CDS ProjectCCDS19826.1
International Mouse Knockout Project StatusFoxk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056493 Ensembl Gene Model | MGI Sequence Detail 60518 C57BL/6J ±  kb
transcript ENSMUST00000072837 Ensembl | MGI Sequence Detail 7445 Not Applicable 
polypeptide ENSMUSP00000072616 Ensembl | MGI Sequence Detail 719 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(5) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR008984 SMAD/FHA domain
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007631 forkhead box protein K1
References (Earliest) J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
(Latest) J:199180 Sel S, et al., The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina. Gene Expr Patterns. 2013 Oct;13(7):280-6
All references(54)
Other
accession IDs
MGD-MRK-12338, MGI:2140907, MGI:97042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory