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Foxk1 Gene Detail
Summary
  • Symbol
    Foxk1
  • Name
    forkhead box K1
  • Synonyms
    A630048H08Rik, Mnf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347488
    NCBI Gene: 17425
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142387252-142447766 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 81.53 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347488
protein coding gene Chr5:142387252-142447770 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030310
protein coding gene Chr5:147627153-147691920 (+)
A/J MGP_AJ_G0030279
protein coding gene Chr5:141313619-141376562 (+)
AKR/J MGP_AKRJ_G0030211
protein coding gene Chr5:145722461-145785084 (+)
BALB/cJ MGP_BALBcJ_G0030296
protein coding gene Chr5:142561190-142622669 (+)
C3H/HeJ MGP_C3HHeJ_G0030007
protein coding gene Chr5:146543814-146608510 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030741
protein coding gene Chr5:153042446-153109075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027959
protein coding gene Chr5:135128726-135192555 (+)
CAST/EiJ MGP_CASTEiJ_G0029412
protein coding gene Chr5:145991691-146058835 (+)
CBA/J MGP_CBAJ_G0029977
protein coding gene Chr5:159287083-159358307 (+)
DBA/2J MGP_DBA2J_G0030127
protein coding gene Chr5:141091597-141152722 (+)
FVB/NJ MGP_FVBNJ_G0030082
protein coding gene Chr5:140280660-140341977 (+)
LP/J MGP_LPJ_G0030213
protein coding gene Chr5:148251370-148314377 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030113
protein coding gene Chr5:161815259-161877633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030781
protein coding gene Chr5:145577850-145638919 (+)
PWK/PhJ MGP_PWKPhJ_G0029127
protein coding gene Chr5:140155825-140218330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028963
protein coding gene Chr5:143304354-143375590 (+)
WSB/EiJ MGP_WSBEiJ_G0029486
protein coding gene Chr5:146366964-146432758 (+)



Homology
more
  • Human Ortholog
    FOXK1, forkhead box K1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXK1, forkhead box K1
  • Synonyms
    FOXK1L
  • Links
    NCBI Gene ID: 221937
    neXtProt AC: NX_P85037
    UniProt: P85037

  • Chr Location
    7p22.1; chr7:4682295-4771442 (+)  GRCh38

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056493 Ensembl Gene Model | MGI Sequence Detail 60515 C57BL/6J ±  kb
    transcript ENSMUST00000072837 Ensembl | MGI Sequence Detail 7439 Not Applicable  
    polypeptide ENSMUSP00000072616 Ensembl | MGI Sequence Detail 719 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 18
      Primer pair 6
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12338, MGI:2140907, MGI:97042
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
    • Latest
      J:336081 Fujinuma S, et al., FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Cell Rep. 2023 May 30;42(5):112530

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory