Foxk1
Gene Detail

Symbol Name ID

Foxk1 forkhead box K1 MGI:1347488

Synonyms

A630048H08Rik, Mnf

Feature Type

protein coding gene

Genetic Map

Chromosome 5

81.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr5:142401497-142462014 bp, + strand From Ensembl annotation of GRCm38   60518 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:82414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxk1

Human homologs

Human Homolog		FOXK1, forkhead box K1
NCBI Gene ID		221937
neXtProt AC		NX_P85037
Human Synonyms		FOXK1L
Human Chr (Location)		7p22.1; chr7:4721930-4811074 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(1) Gene trapped(22)
 

Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cell differentiation, embryo development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (159)    Tissues (113)    Images (34)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	115
RT-PCR	38

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000056493 (Evidence)
Entrez Gene	17425 (Evidence)
DFCI	TC1580112, TC1602071, TC1604631
PDB	2A3S, 2D2W
Consensus CDS Project	CCDS19826.1
International Mouse Knockout Project Status	Foxk1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000056493	Ensembl Gene Model | MGI Sequence Detail	60518	C57BL/6J
transcript	ENSMUST00000072837	Ensembl | MGI Sequence Detail	7445	Not Applicable
polypeptide	ENSMUSP00000072616	Ensembl | MGI Sequence Detail	719	Not Applicable

All sequences(29) RefSeq(3) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(131 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR008984	SMAD/FHA domain
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007631	forkhead box protein K1

References

(Earliest) J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
(Latest) J:190255 Shi X, et al., Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors. Biochem J. 2012 Sep 15;446(3):349-57
All references(52)

Other accession IDs

MGD-MRK-12338, MGI:2140907, MGI:97042