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Foxk1 Gene Detail
Summary
  • Symbol
    Foxk1
  • Name
    forkhead box K1
  • Synonyms
    A630048H08Rik, Mnf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347488
    NCBI Gene: 17425
  • Gene Overview
    MyGene.info: FOXK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:142401497-142462011 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60515 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 81.53 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    FOXK1, forkhead box K1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOXK1, forkhead box K1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FOXK1L
  • Links
    NCBI Gene ID: 221937
    neXtProt AC: NX_P85037
    UniProt: P85037

  • Chr Location
    7p22.1; chr7:4644691-4771443 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are runted and exhibit a reduced myogenic progenitor cell population with impaired cell cycle progression (G0/G1 arrest) and decreased proliferative capacity that results in severe impairment of skeletal muscle regeneration following injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054857 VEGA Gene Model | MGI Sequence Detail 60515 C57BL/6J ±  kb
    transcript OTTMUST00000135930 VEGA | MGI Sequence Detail 7439 Not Applicable  
    polypeptide OTTMUSP00000071847 VEGA | MGI Sequence Detail 719 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      143 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 18
      Primer pair 6
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12338, MGI:2140907, MGI:97042
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:18888 Bassel-Duby R, et al., Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol. 1994 Jul;14(7):4596-605
    • Latest
      J:217746 Bowman CJ, et al., Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Nat Cell Biol. 2014 Dec;16(12):1202-14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory