About   Help   FAQ
Foxa2
Gene Detail
Symbol

Name
ID
Foxa2
forkhead box A2
MGI:1347476
Synonyms
Hnf3b, Hnf-3b, HNF3beta, HNF3-beta, Tcf3b, Tcf-3b
Feature Type
protein coding gene
Genetic Map
Chromosome 2
73.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:148042877-148046969 bp, - strand
From VEGA annotation of GRCm38

  4093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7762  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXA2
Protein SuperFamily: transcription factor HNF-3
Gene Tree: Foxa2

Human
homologs
FOXA2, forkhead box A2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3170
neXtProt AC: NX_Q9Y261

Human Synonyms: HNF3B, TCF3B

Human Chr (Location): 20p11; chr20:22581004-22585463 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for targeted null mutations fail to form a distinct node, lack a notochord, and die by embryonic day 10 or 11. Mutants also exhibit defects of somite and neural tube organization, and lack a floor plate and motor neurons.
 
Interactions
Foxa2 interacts with 149 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process adult locomotory behavior, anatomical structure formation involved in morphogenesis, ...
Component cytoplasm, nucleus
Function DNA binding, double-stranded DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (523 records)
Data Summary: Results (1295)    Tissues (582)    Images (430)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 446
RNA in situ 703
In situ reporter (knock in) 12
RT-PCR 109
RNase protection 25
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxa2 ; ZFIN foxa2    NEW 
Molecular
reagents
All nucleic(64) Genomic(7) cDNA(42) Primer pair(14) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015678 (Evidence)
Ensembl Gene Model ENSMUSG00000037025 (Evidence)
Entrez Gene 15376 (Evidence)
UniGene 938
DFCI TC1608705, TC1584073
DoTS DT.488237, DT.99846201, DT.94169167
NIA Mouse Gene Index U023461
Consensus CDS Project CCDS16836.1, CCDS71157.1
International Mouse Phenotyping Consortium Status Foxa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015678 VEGA Gene Model | MGI Sequence Detail 4093 C57BL/6J ±  kb
transcript OTTMUST00000037260 VEGA | MGI Sequence Detail 2070 Not Applicable 
polypeptide OTTMUSP00000016694 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018533 Forkhead box protein, C-terminal
InterPro IPR013638 Fork-head N-terminal
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007603 hepatocyte nuclear factor 3-beta
References
(Earliest) J:20860 Lai E, et al., Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 1991 Mar;5(3):416-27
(Latest) J:222248 Fossat N, et al., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
All references(636)
Other
accession IDs
MGD-MRK-10805, MGD-MRK-14750, MGD-MRK-14756, MGD-MRK-16684, MGI:99889

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory