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Foxa2 Gene Detail
Summary
  • Symbol
    Foxa2
  • Name
    forkhead box A2
  • Synonyms
    Hnf3b, Hnf-3b, HNF3beta, HNF3-beta, Tcf3b, Tcf-3b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347476
    NCBI Gene: 15376
  • Gene Overview
    MyGene.info: FOXA2
Location & Maps
more
  • Sequence Map
    Chr2:148042877-148046969 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4093 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 73.38 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    FOXA2, forkhead box A2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXA2, forkhead box A2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HNF3B, TCF3B
  • Links
    NCBI Gene ID: 3170
    neXtProt AC: NX_Q9Y261

  • Chr Location
    20p11; chr20:22581004-22585463 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    104 phenotypes from 8 alleles in 14 genetic backgrounds
    52 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    14
  • Genomic Mutations
    2 involving Foxa2
  • Incidental Mutations
Embryos homozygous for targeted null mutations fail to form a distinct node, lack a notochord, and die by embryonic day 10 or 11. Mutants also exhibit defects of somite and neural tube organization, and lack a floor plate and motor neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015678 VEGA Gene Model | MGI Sequence Detail 4093 C57BL/6J ±  kb
transcript OTTMUST00000037260 VEGA | MGI Sequence Detail 2070 Not Applicable  
polypeptide OTTMUSP00000016694 VEGA | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007603 hepatocyte nuclear factor 3-beta
  • InterPro Domains
    IPR018533 Forkhead box protein, C-terminal
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR013638 Fork-head N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 64
    Genomic 7
    cDNA 42
    Primer pair 14
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10805, MGD-MRK-14750, MGD-MRK-14756, MGD-MRK-16684, MGI:99889
References
more
  • Summaries
    All 666
    Developmental Gene Expression 548
    Gene Ontology 35
    Phenotypes 87
  • Earliest
    J:20860 Lai E, et al., Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 1991 Mar;5(3):416-27
  • Latest
    J:232130 Zhu J, et al., Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3820-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory