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Foxj1 Gene Detail
Summary
  • Symbol
    Foxj1
  • Name
    forkhead box J1
  • Synonyms
    FKHL-13, Hfh4, HFH-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347474
    NCBI Gene: 15223
Location & Maps
more
  • Sequence Map
    Chr11:116330704-116335399 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4696 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXJ1, forkhead box J1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOXJ1, forkhead box J1
    Orthology source: HomoloGene
  • Synonyms
    FKHL13, HFH4, HFH-4
  • Links
    NCBI Gene ID: 2302
    neXtProt AC: NX_Q92949

  • Chr Location
    17q25.1; chr17:76136333-76141299 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1117
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FOXJ1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 7 alleles in 10 genetic backgrounds
    15 phenotypes from multigenic genotypes
    4 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Targeted
    7
  • Transgenic
    1
  • Incidental Mutations
Animals homozygous for targeted mutations in this gene exhibit random determination of left-right asymmetry and defective ciliogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003841 VEGA Gene Model | MGI Sequence Detail 4696 C57BL/6J ±  kb
transcript OTTMUST00000008445 VEGA | MGI Sequence Detail 2623 Not Applicable  
polypeptide OTTMUSP00000004095 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007628 forkhead box protein J1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 33
    Genomic 6
    cDNA 20
    Primer pair 4
    Other 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16697, MGI:99901
References
more
  • Summaries
    All 117
    Developmental Gene Expression 78
    Gene Ontology 18
    Phenotypes 19
  • Earliest
    J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
  • Latest
    J:224948 Lin C, et al., A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory