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Foxj1 Gene Detail
Summary
  • Symbol
    Foxj1
  • Name
    forkhead box J1
  • Synonyms
    FKHL-13, Hfh4, HFH-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347474
    NCBI Gene: 15223
  • Gene Overview
    MyGene.info: FOXJ1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:116330704-116335399 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4696 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.16 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXJ1, forkhead box J1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOXJ1, forkhead box J1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL13, HFH4, HFH-4
  • Links
    NCBI Gene ID: 2302
    neXtProt AC: NX_Q92949
    UniProt: Q92949

  • Chr Location
    17q25.1; chr17:76136333-76141299 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1117
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FOXJ1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Foxj1 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 7 alleles in 10 genetic backgrounds
    15 phenotypes from multigenic genotypes
    4 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for targeted mutations in this gene exhibit random determination of left-right asymmetry and defective ciliogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003841 VEGA Gene Model | MGI Sequence Detail 4696 C57BL/6J ±  kb
    transcript OTTMUST00000008445 VEGA | MGI Sequence Detail 2623 Not Applicable  
    polypeptide OTTMUSP00000004095 VEGA | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      27 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 6
      cDNA 21
      Primer pair 7
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16697, MGI:99901
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 99
      Diseases 2
      Gene Ontology 18
      Phenotypes 22
    • Earliest
      J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
    • Latest
      J:253968 Abdelhamed Z, et al., A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice. Development. 2018 Jan 9;145(1):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory