Foxd3
Gene Detail

Symbol Name ID

Foxd3 forkhead box D3 MGI:1347473

Synonyms

CWH3, Genesis, Hfh2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:99656299-99658622 bp, + strand From VEGA annotation of GRCm38   2324 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Foxd3

Human homologs

Human Homolog		FOXD3, forkhead box D3
NCBI Gene ID		27022
neXtProt AC		NX_Q9UJU5
Human Synonyms		AIS1, Genesis, HFH2, VAMAS2
Human Chr (Location)		1p31.3; chr1:63788730-63790797 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXD3

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for null alleles dsiplay embryonic lethality with failure of primitive streak formation and gastrulation and failure to derive cultures of embryonic or trophoblast stem cells.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	axon extension involved in axon guidance, branching involved in ureteric bud morphogenesis, ...
Component	nuclear chromatin, nucleus, ...
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (48 records)
Data Summary: Results (344)    Tissues (228)    Images (84)
Theiler Stages: 2, 3, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	22
RNA in situ	253
Northern blot	33
RT-PCR	36

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(15) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007976 (Evidence)
Ensembl Gene Model	ENSMUSG00000067261 (Evidence)
Entrez Gene	15221 (Evidence)
UniGene	4758
DFCI	TC1590811, TC1663465
DoTS	DT.40145289
NIA Mouse Gene Index	U004533
Consensus CDS Project	CCDS18383.1
International Mouse Knockout Project Status	Foxd3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007976	VEGA Gene Model | MGI Sequence Detail	2324	C57BL/6J
transcript	OTTMUST00000018082	VEGA | MGI Sequence Detail	2324	Not Applicable
polypeptide	OTTMUSP00000008307	VEGA | MGI Sequence Detail	469	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007611	forkhead box protein D3

References

(Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:184447 Hu J, et al., c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. J Neurosci. 2012 Apr 18;32(16):5362-73
All references(82)

Other accession IDs

MGD-MRK-16699, MGI:99903