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Foxd3
Gene Detail
 Symbol
Name
ID
Foxd3
forkhead box D3
MGI:1347473
Synonyms CWH3, Genesis, Hfh2
Feature Type protein coding gene
Genetic Map
Chromosome 4
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:99656299-99658622 bp, + strand
From VEGA annotation of GRCm38

  2324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Foxd3

Human
homologs
Human Homolog FOXD3, forkhead box D3
NCBI Gene ID 27022
neXtProt AC  NX_Q9UJU5
Human Synonyms  AIS1, Genesis, HFH2, VAMAS2
Human Chr (Location)  1p31.3; chr1:63323059-63325126 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXD3
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
 
Mice homozygous for null alleles dsiplay embryonic lethality with failure of primitive streak formation and gastrulation and failure to derive cultures of embryonic or trophoblast stem cells.
 
Interactions
Foxd3 interacts with 137 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process axon extension involved in axon guidance, embryonic placenta development, ...
Component nuclear chromatin, nucleus, ...
Function DNA binding, DNA binding, bending, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (353)    Tissues (233)    Images (90)
Theiler Stages: 2, 3, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 22
RNA in situ 262
Northern blot 33
RT-PCR 36
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007976 (Evidence)
Ensembl Gene ModelENSMUSG00000067261 (Evidence)
Entrez Gene15221 (Evidence)
UniGene4758
DFCITC1590811, TC1663465
DoTSDT.40145289
NIA Mouse Gene IndexU004533
Consensus CDS ProjectCCDS18383.1
International Mouse Knockout Project StatusFoxd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007976 VEGA Gene Model | MGI Sequence Detail 2324 C57BL/6J ±  kb
transcript OTTMUST00000018082 VEGA | MGI Sequence Detail 2324 Not Applicable 
polypeptide OTTMUSP00000008307 VEGA | MGI Sequence Detail 469 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007611 forkhead box protein D3
References (Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:208409 Reinert RB, et al., Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development. 2014 Apr;141(7):1480-91
All references(88)
Other
accession IDs
MGD-MRK-16699, MGI:99903

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory