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Foxd3 Gene Detail
Summary
  • Symbol
    Foxd3
  • Name
    forkhead box D3
  • Synonyms
    CWH3, Genesis, Hfh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347473
    NCBI Gene: 15221
  • Gene Overview
    MyGene.info: FOXD3
Location & Maps
more
  • Sequence Map
    Chr4:99656299-99658622 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2324 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 45.71 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXD3, forkhead box D3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXD3, forkhead box D3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIS1, Genesis, HFH2, VAMAS2
  • Links
    NCBI Gene ID: 27022
    neXtProt AC: NX_Q9UJU5
    UniProt: Q9UJU5

  • Chr Location
    1p31.3; chr1:63323059-63325126 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 4 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Foxd3
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for null alleles dsiplay embryonic lethality with failure of primitive streak formation and gastrulation and failure to derive cultures of embryonic or trophoblast stem cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007976 VEGA Gene Model | MGI Sequence Detail 2324 C57BL/6J ±  kb
transcript OTTMUST00000018082 VEGA | MGI Sequence Detail 2324 Not Applicable  
polypeptide OTTMUSP00000008307 VEGA | MGI Sequence Detail 469 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 17
    cDNA 14
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16699, MGI:99903
References
more
  • Summaries
    All 99
    Developmental Gene Expression 58
    Gene Ontology 11
    Phenotypes 22
  • Earliest
    J:23094 Davisson MT, New chromosome aberrations. Mouse News Lett. 1988;80:166
  • Latest
    J:240621 Francius C, et al., Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Front Mol Neurosci. 2016;9:145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory