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Foxd3 Gene Detail
Summary
  • Symbol
    Foxd3
  • Name
    forkhead box D3
  • Synonyms
    CWH3, Genesis, Hfh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347473
    NCBI Gene: 15221
  • Gene Overview
    MyGene.info: FOXD3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:99656299-99658622 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 45.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347473
protein coding gene Chr4:99656299-99658671 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028481
protein coding gene Chr4:99920463-99922776 (+)
A/J MGP_AJ_G0028444
protein coding gene Chr4:96429700-96432023 (+)
AKR/J MGP_AKRJ_G0028391
protein coding gene Chr4:98764522-98766845 (+)
BALB/cJ MGP_BALBcJ_G0028462
protein coding gene Chr4:96674519-96677019 (+)
C3H/HeJ MGP_C3HHeJ_G0028175
protein coding gene Chr4:99586692-99589015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028901
protein coding gene Chr4:103700646-103702969 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026193
protein coding gene Chr4:91809314-91811629 (+)
CAST/EiJ MGP_CASTEiJ_G0027615
protein coding gene Chr4:97373000-97375334 (+)
CBA/J MGP_CBAJ_G0028144
protein coding gene Chr4:106901269-106903592 (+)
DBA/2J MGP_DBA2J_G0028294
protein coding gene Chr4:96148165-96150511 (+)
FVB/NJ MGP_FVBNJ_G0028261
protein coding gene Chr4:94999668-95001433 (+)
LP/J MGP_LPJ_G0028394
protein coding gene Chr4:100222439-100224752 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028289
protein coding gene Chr4:112599517-112601830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028939
protein coding gene Chr4:99014945-99018739 (+)
PWK/PhJ MGP_PWKPhJ_G0027340
protein coding gene Chr4:94306609-94308872 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027162
protein coding gene Chr4:96466538-96468856 (+)
WSB/EiJ MGP_WSBEiJ_G0027693
protein coding gene Chr4:99165520-99167842 (+)



Homology
more
  • Human Ortholog
    FOXD3, forkhead box D3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXD3, forkhead box D3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIS1, Genesis, HFH2, VAMAS2
  • Links
    NCBI Gene ID: 27022
    neXtProt AC: NX_Q9UJU5
    UniProt: Q9UJU5

  • Chr Location
    1p31.3; chr1:63323059-63325126 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FOXD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles dsiplay embryonic lethality with failure of primitive streak formation and gastrulation and failure to derive cultures of embryonic or trophoblast stem cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067261 Ensembl Gene Model | MGI Sequence Detail 2324 C57BL/6J ±  kb
    transcript ENSMUST00000087285 Ensembl | MGI Sequence Detail 2324 Not Applicable  
    polypeptide ENSMUSP00000084541 Ensembl | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001766 Fork head domain
      IPR018122 Fork head domain conserved site1
      IPR030456 Fork head domain conserved site 2
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16699, MGI:99903
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 63
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory