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Foxf1
Gene Detail
Symbol

Name
ID
Foxf1
forkhead box F1
MGI:1347470
Synonyms
Foxf1, Foxf1a, Freac-1, FREAC1, Hfh8, HFH-8
Feature Type
protein coding gene
Genetic Map
Chromosome 8
70.31 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:121084386-121088144 bp, + strand
From VEGA annotation of GRCm38

  3759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXF1
Gene Tree: Foxf1

Human
homologs
FOXF1, forkhead box F1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2294
neXtProt AC: NX_Q12946

Human Synonyms: ACDMPV, FKHL5, FREAC1

Human Chr (Location): 16q24; chr16:86510527-86514464 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FOXF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutation of this gene results in mid-gestation lethality, defects in extraembryonic and lateral plate mesoderm differentiation, failure of embryo turning, absence of yolk sac and allantois vasculogenesis, retarded somite and posterior embryo development.
 
Expression
Literature Summary: (54 records)
Data Summary: Results (533)    Tissues (362)    Images (104)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 493
Northern blot 20
RT-PCR 20
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FOXF1 ; Xenbase foxf1    NEW 
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(23) Primer pair(6) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000043020 (Evidence)
Ensembl Gene Model ENSMUSG00000042812 (Evidence)
Entrez Gene 15227 (Evidence)
UniGene 33897
DFCI TC1632592, TC1610214, TC1672726
DoTS DT.40174160, DT.101712192
NIA Mouse Gene Index U009892
Consensus CDS Project CCDS22722.2
International Mouse Phenotyping Consortium Status Foxf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043020 VEGA Gene Model | MGI Sequence Detail 3759 C57BL/6J ±  kb
transcript OTTMUST00000112932 VEGA | MGI Sequence Detail 2415 Not Applicable 
polypeptide OTTMUSP00000063254 VEGA | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007621 forkhead box protein F1
References
(Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:215092 Sen P, et al., Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in foxf1 heterozygous knockout mice. PLoS One. 2014;9(4):e94390
All references(92)
Other
accession IDs
MGD-MRK-16693, MGI:2142552, MGI:99897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory