Foxf1
Gene Detail

Symbol Name ID

Foxf1 forkhead box F1 MGI:1347470

Synonyms

Foxf1, Foxf1a, Freac-1, FREAC1, Hfh8, HFH-8

Feature Type

protein coding gene

Genetic Map

Chromosome 8

70.31 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:121084474-121086879 bp, + strand From NCBI annotation of GRCm38   2406 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Foxf1 ± 2 cM)

Gene Tree: Foxf1

Human ortholog

FOXF1 forkhead box F1 NCBI Gene ID 2294
Human Synonyms: ACDMPV, FKHL5, FREAC1
Human Chr16:86544133-86548070 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human FOXF1 (1)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in mid-gestation lethality, defects in extraembryonic and lateral plate mesoderm differentiation, failure of embryo turning, absence of yolk sac and allantois vasculogenesis, retarded somite and posterior embryo development.

 

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	blood vessel development, branching involved in open tracheal system development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (43 records)
Data Summary: Results (408)    Tissues (263)    Images (88)
Theiler Stages: 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	388
Northern blot	16
RT-PCR	4

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(11) Primer pair(3) Other(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000042812 (Evidence)
Entrez Gene	15227 (Evidence)
DFCI	TC1610214, TC1632592, TC1672726
DoTS	DT.101712192, DT.40174160
NIA Mouse Gene Index	U009892
Consensus CDS Project	CCDS22722.1
International Mouse Knockout Project Status	Foxf1

Sequences

Length	Strain/Species
genomic	15227	NCBI Gene Model | MGI Sequence Detail	2406	C57BL/6J
transcript	NM_010426	RefSeq | MGI Sequence Detail	2425	Not Specified
polypeptide	Q61080	UniProt | EBI | MGI Sequence Detail	378	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007621	forkhead box protein F1

Graphical View of Protein Domain Structure

References

(Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(79)

Other accession IDs

MGD-MRK-16693, MGI:2142552, MGI:99897