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Foxf1
Gene Detail
 Symbol
Name
ID
Foxf1
forkhead box F1
MGI:1347470
Synonyms Foxf1, Foxf1a, Freac-1, FREAC1, Hfh8, HFH-8
Feature Type protein coding gene
Genetic Map
Chromosome 8
70.31 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:121084386-121088144 bp, + strand
From VEGA annotation of GRCm38

  3759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxf1

Human
homologs
Human Homolog FOXF1, forkhead box F1
NCBI Gene ID 2294
neXtProt AC  NX_Q12946
Human Synonyms  ACDMPV, FKHL5, FREAC1
Human Chr (Location)  16q24; chr16:86510527-86514464 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXF1
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in mid-gestation lethality, defects in extraembryonic and lateral plate mesoderm differentiation, failure of embryo turning, absence of yolk sac and allantois vasculogenesis, retarded somite and posterior embryo development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process blood vessel development, branching involved in open tracheal system development, ...
Component nucleus, transcription factor complex
Function DNA binding, DNA binding, bending, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (515)    Tissues (355)    Images (95)
Theiler Stages: 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 487
Northern blot 20
RT-PCR 8
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(32) Genomic(2) cDNA(22) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043020 (Evidence)
Ensembl Gene ModelENSMUSG00000042812 (Evidence)
Entrez Gene15227 (Evidence)
UniGene33897
DFCITC1610214, TC1632592, TC1672726
DoTSDT.101712192, DT.40174160
NIA Mouse Gene IndexU009892
Consensus CDS ProjectCCDS22722.2
International Mouse Knockout Project StatusFoxf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043020 VEGA Gene Model | MGI Sequence Detail 3759 C57BL/6J ±  kb
transcript OTTMUST00000112932 VEGA | MGI Sequence Detail 2415 Not Applicable 
polypeptide OTTMUSP00000063254 VEGA | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007621 forkhead box protein F1
References (Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:206871 Reeder AL, et al., Exogenous Sonic hedgehog protein does not rescue cultured intestine from atresia formation. J Surg Res. 2014 Mar;187(1):14-8
All references(88)
Other
accession IDs
MGD-MRK-16693, MGI:2142552, MGI:99897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory