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Foxh1
Gene Detail
 Symbol
Name
ID
Foxh1
forkhead box H1
MGI:1347465
Synonyms Fast2
Feature Type protein coding gene
Genetic Map
Chromosome 15
36.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:76668307-76669873 bp, - strand
From NCBI annotation of GRCm38

  1567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Foxh1

Human
homologs
Human Homolog FOXH1, forkhead box H1
NCBI Gene ID 8928
neXtProt AC  NX_O75593
Human Synonyms  FAST1, FAST-1
Human Chr (Location)  8q24.3; chr8:144473732-144476335 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXH1
Alleles
and
phenotypes
All alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Conditional knockout of this gene in the lateral plate mesoderm results in death within a few days after birth. Mutant animals exhibit right isomerism affecting the heart, lungs, and stomach.
 
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process anterior/posterior pattern specification, aorta morphogenesis, ...
Component activin responsive factor complex, nuclear chromatin, ...
Function androgen receptor binding, bHLH transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (101)    Tissues (89)    Images (16)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 17, 18, 19, 20, 21, 23, 28
Assay TypeResults
RNA in situ 79
RT-PCR 22
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(10) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000033837 (Evidence)
Entrez Gene14106 (Evidence)
NIA Mouse Gene IndexU123214
Consensus CDS ProjectCCDS27584.1
International Mouse Knockout Project StatusFoxh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14106 NCBI Gene Model | MGI Sequence Detail 1567 C57BL/6J ±  kb
transcript NM_007989 RefSeq | MGI Sequence Detail 1366 Not Specified 
polypeptide O88621 UniProt | EBI | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007624 forkhead box protein H1
Graphical View of Protein Domain Structure
References (Earliest) J:48930 Labbe E, et al., Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell. 1998 Jul;2(1):109-20
(Latest) J:195995 Redshaw N, et al., TGF-beta/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. PLoS One. 2013;8(1):e55186
All references(55)
Other
accession IDs
MGI:1277981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory