Foxh1
Gene Detail

Symbol Name ID

Foxh1 forkhead box H1 MGI:1347465

Synonyms

Fast2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

36.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:76668307-76669873 bp, - strand From NCBI annotation of GRCm38   1567 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Foxh1

Human homologs

Human Homolog		FOXH1, forkhead box H1
NCBI Gene ID		8928
neXtProt AC		NX_O75593
Human Synonyms		FAST1, FAST-1
Human Chr (Location)		8q24.3; chr8:145699115-145701718 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXH1

Alleles and phenotypes

All alleles(18) : Targeted(4) Gene trapped(14)
 

Conditional knockout of this gene in the lateral plate mesoderm results in death within a few days after birth. Mutant animals exhibit right isomerism affecting the heart, lungs, and stomach.

 

Gene Ontology (GO) classifications

All GO classifications: (64 annotations)

Process	anterior/posterior pattern specification, aorta morphogenesis, ...
Component	activin responsive factor complex, nucleus, ...
Function	androgen receptor binding, co-SMAD binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (101)    Tissues (89)    Images (16)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 17, 18, 19, 20, 21, 23, 28

Assay Type	Results
RNA in situ	79
RT-PCR	22

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(10) Primer pair(2) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000033837 (Evidence)
Entrez Gene	14106 (Evidence)
NIA Mouse Gene Index	U123214
Consensus CDS Project	CCDS27584.1
International Mouse Knockout Project Status	Foxh1

Sequences

Length	Strain/Species
genomic	14106	NCBI Gene Model | MGI Sequence Detail	1567	C57BL/6J
transcript	NM_007989	RefSeq | MGI Sequence Detail	1366	Not Specified
polypeptide	O88621	UniProt | EBI | MGI Sequence Detail	401	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007624	forkhead box protein H1

Graphical View of Protein Domain Structure

References

(Earliest) J:48930 Labbe E, et al., Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell. 1998 Jul;2(1):109-20
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(55)

Other accession IDs

MGI:1277981