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Foxh1
Gene Detail
Symbol

Name
ID
Foxh1
forkhead box H1
MGI:1347465
Synonyms
Fast2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:76668284-76669948 bp, - strand
From Ensembl annotation of GRCm38

  1665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: FOXH1
Gene Tree: Foxh1

Human
homologs
FOXH1, forkhead box H1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8928
neXtProt AC: NX_O75593

Human Synonyms: FAST1, FAST-1

Human Chr (Location): 8q24.3; chr8:144473732-144476335 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(1) Gene trapped(14) Radiation induced(1) Targeted(4)
Genomic Mutations involving Foxh1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Conditional knockout of this gene in the lateral plate mesoderm results in death within a few days after birth. Mutant animals exhibit right isomerism affecting the heart, lungs, and stomach.
 
Phenotype Images(26)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (23 records)
Data Summary: Results (94)    Tissues (86)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 79
RT-PCR 15
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxh1 ; ZFIN foxh1    NEW 
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(10) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000033837 (Evidence)
Entrez Gene 14106 (Evidence)
NIA Mouse Gene Index U123214
Consensus CDS Project CCDS27584.1
International Mouse Phenotyping Consortium Status Foxh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033837 Ensembl Gene Model | MGI Sequence Detail 1665 C57BL/6J ±  kb
transcript ENSMUST00000037824 Ensembl | MGI Sequence Detail 1306 Not Applicable 
polypeptide ENSMUSP00000036591 Ensembl | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007624 forkhead box protein H1
References
(Earliest) J:48930 Labbe E, et al., Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell. 1998 Jul;2(1):109-20
(Latest) J:217681 Halstead AM, et al., Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning. Mech Dev. 2014 Dec 12;
All references(59)
Other
accession IDs
MGI:1277981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory