About   Help   FAQ
Foxh1
Gene Detail
Symbol

Name
ID
Foxh1
forkhead box H1
MGI:1347465
Synonyms
Fast2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:76668284-76669948 bp, - strand
From Ensembl annotation of GRCm38

  1665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2914  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Foxh1

Human
homologs
Human Homolog FOXH1, forkhead box H1
NCBI Gene ID 8928
neXtProt AC  NX_O75593
Human Synonyms  FAST1, FAST-1
Human Chr (Location)  8q24.3; chr8:144473732-144476335 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(14) Radiation induced(1) Targeted(4)
Genomic Mutations involving Foxh1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Conditional knockout of this gene in the lateral plate mesoderm results in death within a few days after birth. Mutant animals exhibit right isomerism affecting the heart, lungs, and stomach.
 
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (22 records)
Data Summary: Results (94)    Tissues (86)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 79
RT-PCR 15
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(10) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000033837 (Evidence)
Entrez Gene14106 (Evidence)
NIA Mouse Gene IndexU123214
Consensus CDS ProjectCCDS27584.1
International Mouse Knockout Project StatusFoxh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033837 Ensembl Gene Model | MGI Sequence Detail 1665 C57BL/6J ±  kb
transcript ENSMUST00000037824 Ensembl | MGI Sequence Detail 1306 Not Applicable 
polypeptide ENSMUSP00000036591 Ensembl | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007624 forkhead box protein H1
References
(Earliest) J:48930 Labbe E, et al., Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell. 1998 Jul;2(1):109-20
(Latest) J:205747 Polydorou C, et al., Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
All references(56)
Other
accession IDs
MGI:1277981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory