About   Help   FAQ
Foxd1 Gene Detail
Summary
  • Symbol
    Foxd1
  • Name
    forkhead box D1
  • Synonyms
    BF-2, FREAC4, Hfh10, Hfhbf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347463
    NCBI Gene: 15229
  • Gene Overview
    MyGene.info: FOXD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:98354242-98356703 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2462 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 51.96 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXD1, forkhead box D1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FOXD1, forkhead box D1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL8, FREAC4, FREAC-4
  • Links
    NCBI Gene ID: 2297
    neXtProt AC: NX_Q16676
    UniProt: Q16676

  • Chr Location
    5q13.2; chr5:73446256-73448527 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for this targeted mutation die within 24 hours after birth with severe defects in nephrogenesis, and abnormal development of the renal collecting system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020973 VEGA Gene Model | MGI Sequence Detail 2462 C57BL/6J ±  kb
    transcript OTTMUST00000049601 VEGA | MGI Sequence Detail 2462 Not Applicable  
    polypeptide OTTMUSP00000023010 VEGA | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 26
      Primer pair 2
      Other 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-16691, MGI:2145223, MGI:99895
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 94
      Gene Ontology 10
      Phenotypes 39
    • Earliest
      J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory