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Foxd1 Gene Detail
Summary
  • Symbol
    Foxd1
  • Name
    forkhead box D1
  • Synonyms
    BF-2, FREAC4, Hfh10, Hfhbf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347463
    NCBI Gene: 15229
  • Gene Overview
    MyGene.info: FOXD1
Location & Maps
more
  • Sequence Map
    Chr13:98354242-98356703 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2462 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 51.96 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXD1, forkhead box D1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FOXD1, forkhead box D1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL8, FREAC4, FREAC-4
  • Links
    NCBI Gene ID: 2297
    neXtProt AC: NX_Q16676

  • Chr Location
    5q13.2; chr5:73446256-73448527 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
Mice homozygous for this targeted mutation die within 24 hours after birth with severe defects in nephrogenesis, and abnormal development of the renal collecting system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020973 VEGA Gene Model | MGI Sequence Detail 2462 C57BL/6J ±  kb
transcript OTTMUST00000049601 VEGA | MGI Sequence Detail 2462 Not Applicable  
polypeptide OTTMUSP00000023010 VEGA | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007609 forkhead box protein D1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 32
    cDNA 26
    Primer pair 2
    Other 4

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-16691, MGI:2145223, MGI:99895
References
more
  • Summaries
    All 122
    Developmental Gene Expression 79
    Gene Ontology 10
    Phenotypes 28
  • Earliest
    J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
  • Latest
    J:231164 Chang YT, et al., DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys. J Clin Invest. 2016 Feb 1;126(2):721-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory