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Mmp23
Gene Detail
Symbol

Name
ID
Mmp23
matrix metallopeptidase 23
MGI:1347361
Synonyms
CA-MMP, cysteine array matrix metalloproteinase
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.85 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:155650655-155653384 bp, - strand
From VEGA annotation of GRCm38

  2730 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMP23B
Gene Tree: Mmp23

Human
homologs
MMP23B, matrix metallopeptidase 23B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8510
neXtProt AC: NX_O75900

Human Synonyms: MIFR, MIFR-1, MMP22, MMP23A

Human Chr (Location): 1p36.3; chr1:1632181-1634654 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mmp23 interacts with 26 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process proteolysis
Component endoplasmic reticulum, extracellular matrix, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (15)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
RT-PCR 12
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MMP23B ZFIN mmp23bb    NEW 
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010727 (Evidence)
Ensembl Gene Model ENSMUSG00000029061 (Evidence)
Entrez Gene 26561 (Evidence)
UniGene 29373
DFCI TC1655148, TC1582587
DoTS DT.91364402, DT.530860
NIA Mouse Gene Index U025875
EC 3.4.24.-
Consensus CDS Project CCDS19034.1
International Mouse Phenotyping Consortium Status Mmp23
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010727 VEGA Gene Model | MGI Sequence Detail 2730 C57BL/6J ±  kb
transcript OTTMUST00000025041 VEGA | MGI Sequence Detail 1434 Not Applicable 
polypeptide OTTMUSP00000011475 VEGA | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR003582 Metridin-like ShK toxin
InterPro IPR021190 Peptidase M10A
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
Protein Ontology PR:000010916 matrix metalloproteinase-23
References
(Earliest) J:57238 Pei D, CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch. FEBS Lett. 1999 Aug 27;457(2):262-70
(Latest) J:213098 Tocchi A, et al., Functional interactions between matrix metalloproteinases and glycosaminoglycans. FEBS J. 2013 May;280(10):2332-41
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory