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Homer3
Gene Detail
Symbol

Name
ID
Homer3
homer homolog 3 (Drosophila)
MGI:1347359
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:70282827-70294361 bp, + strand
From VEGA annotation of GRCm38

  11535 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOMER3
Gene Tree: Homer3

Human
homologs
HOMER3, homer scaffolding protein 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9454
neXtProt AC: NX_Q9NSC5

Human Synonyms: HOMER-3, VESL3

Human Chr (Location): 19p13.11; chr19:18929201-18941258 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
 
Homozygous mutants exhibit normal sensitivity to cocaine.
 
Interactions
Homer3 interacts with 152 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase homer3 ; ZFIN homer3    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022250 (Evidence)
Ensembl Gene Model ENSMUSG00000003573 (Evidence)
Entrez Gene 26558 (Evidence)
NIA Mouse Gene Index U101083
Consensus CDS Project CCDS22363.1, CCDS52569.1
International Mouse Phenotyping Consortium Status Homer3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022250 VEGA Gene Model | MGI Sequence Detail 11535 C57BL/6J ±  kb
transcript OTTMUST00000052956 VEGA | MGI Sequence Detail 2323 Not Applicable 
polypeptide OTTMUSP00000025159 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR000697 WH1/EVH1 domain
Protein Ontology PR:000008680 homer protein homolog 3
References
(Earliest) J:50718 Xiao B, et al., Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 Oct;21(4):707-16
(Latest) J:210337 Tao-Cheng JH, et al., Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Neuroscience. 2014 Apr 25;266:80-90
All references(46)
Other
accession IDs
MGI:2142770

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory