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Slc7a11
Gene Detail
 Symbol
Name
ID
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
MGI:1347355
Synonyms 9930009M05Rik, sut, System xc, xc, xCT
Feature Type protein coding gene
Genetic Map
Chromosome 3
21.72 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:50364936-50443613 bp, - strand
From VEGA annotation of GRCm38

  78678 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a11

Human
homologs
Human Homolog SLC7A11, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
NCBI Gene ID 23657
neXtProt AC  NX_Q9UPY5
Human Synonyms  CCBR1, xCT
Human Chr (Location)  4q28-q32; chr4:138164094-138242418 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors.
 
Human Diseases Modeled Using Mouse Slc7a11 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc7a11 interacts with 523 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process amino acid transmembrane transport, amino acid transport, ...
Component cell surface, cytoskeleton, ...
Function amino acid transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (40)    Images (25)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 135
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021262 (Evidence)
Ensembl Gene ModelENSMUSG00000027737 (Evidence)
Entrez Gene26570 (Evidence)
DFCITC1582214, TC1595124, TC1605840, TC1608522, TC1614480, TC1758961
DoTSDT.101130400, DT.101360540, DT.101387186, DT.111061893, DT.55235659, DT.91401731
NIA Mouse Gene IndexU024003
Consensus CDS ProjectCCDS17335.1
International Mouse Knockout Project StatusSlc7a11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021262 VEGA Gene Model | MGI Sequence Detail 78678 C57BL/6J ±  kb
transcript OTTMUST00000050384 VEGA | MGI Sequence Detail 9227 Not Applicable 
polypeptide OTTMUSP00000023507 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(1129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004760 L-type amino acid transporter
Protein Ontology PR:000015196 cystine/glutamate transporter
References (Earliest) J:14274 Lane PW, Subtle gray (sut); small with kinky tail (skt). Mouse News Lett. 1988;80:165
(Latest) J:208250 McCullagh EA, et al., Behavioral characterization of system xc- mutant mice. Behav Brain Res. 2014 May 15;265:1-11
All references(55)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14656, MGI:2139719, MGI:2442155, MGI:98448

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory