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Slc7a11
Gene Detail
Symbol

Name
ID
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
MGI:1347355
Synonyms
9930009M05Rik, sut, System xc, xc, xCT
Feature Type
protein coding gene
Genetic Map
Chromosome 3
21.72 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:49892526-50443614 bp, - strand
From VEGA annotation of GRCm38

  551089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC7A11
Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a11

Human
homologs
SLC7A11, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23657
neXtProt AC: NX_Q9UPY5

Human Synonyms: CCBR1, xCT

Human Chr (Location): 4q28.3; chr4:138164094-138312660 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors.
 
Human Diseases Modeled in Mice Using Slc7a11 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc7a11 interacts with 522 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (135)    Tissues (40)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc7a11    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021262 (Evidence)
Ensembl Gene Model ENSMUSG00000027737 (Evidence)
Entrez Gene 26570 (Evidence)
DFCI TC1608522, TC1605840, TC1595124, TC1582214, TC1758961, TC1614480
DoTS DT.111061893, DT.101387186, DT.101360540, DT.101130400, DT.55235659, DT.91401731
NIA Mouse Gene Index U024003
Consensus CDS Project CCDS17335.1
International Mouse Phenotyping Consortium Status Slc7a11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021262 VEGA Gene Model | MGI Sequence Detail 551089 C57BL/6J ±  kb
transcript OTTMUST00000050384 VEGA | MGI Sequence Detail 9223 Not Applicable 
polypeptide OTTMUSP00000023507 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(6603 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004760 L-type amino acid transporter
Protein Ontology PR:000015196 cystine/glutamate transporter
References
(Earliest) J:14274 Lane PW, Subtle gray (sut); small with kinky tail (skt). Mouse News Lett. 1988;80:165
(Latest) J:220466 Jiang L, et al., Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015 Apr 2;520(7545):57-62
All references(59)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14656, MGI:2139719, MGI:2442155, MGI:98448

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory