Slc7a11
Gene Detail

Symbol Name ID

Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 MGI:1347355

Synonyms

9930009M05Rik, sut, System x, x, xCT

Feature Type

protein coding gene

Genetic Map

Chromosome 3

21.72 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:50364936-50443613 bp, - strand From VEGA annotation of GRCm38   78678 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22684  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a11

Human homologs

Human Homolog		SLC7A11, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
NCBI Gene ID		23657
neXtProt AC		NX_Q9UPY5
Human Synonyms		CCBR1, xCT
Human Chr (Location)		4q28-q32; chr4:139085248-139163503 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Spontaneous(1) Chemically induced(1)
 

Homozygous mutant mice show a reduction in yellow pigment resulting in dilution of agouti; only pinna hairs are affected in nonagouti mice. Mice homozygous for an ENU-induced allele exhibit decreased survival of LPS-induced macrophages and increased incidence of chemically-induced tumors.

 
Human Diseases Modeled Using Mouse Slc7a11 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	cytoskeleton, integral to membrane, ...
Function	amino acid transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (107)    Tissues (12)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	107

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000021262 (Evidence)
Ensembl Gene Model	ENSMUSG00000027737 (Evidence)
Entrez Gene	26570 (Evidence)
DFCI	TC1582214, TC1595124, TC1605840, TC1608522, TC1614480, TC1758961
DoTS	DT.101130400, DT.101360540, DT.101387186, DT.111061893, DT.55235659, DT.91401731
NIA Mouse Gene Index	U024003
Consensus CDS Project	CCDS17335.1
International Mouse Knockout Project Status	Slc7a11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021262	VEGA Gene Model | MGI Sequence Detail	78678	C57BL/6J
transcript	OTTMUST00000050384	VEGA | MGI Sequence Detail	9227	Not Applicable
polypeptide	OTTMUSP00000023507	VEGA | MGI Sequence Detail	502	Not Applicable

All sequences(57) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(771 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002293	Amino acid/polyamine transporter I
InterPro	IPR004760	L-type amino acid transporter
Protein Ontology	PR:000015196	cystine/glutamate transporter

References

(Earliest) J:14274 Lane PW, Subtle gray (sut); small with kinky tail (skt). Mouse News Lett. 1988;80:165
(Latest) J:193772 Kobayashi S, et al., Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat. Free Radic Biol Med. 2012 Oct 17;53(12):2197-2203
All references(51)

Other accession IDs

MGD-MRK-14656, MGI:2139719, MGI:2442155, MGI:98448