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Hunk Gene Detail
Summary
  • Symbol
    Hunk
  • Name
    hormonally upregulated Neu-associated kinase
  • Synonyms
    Bstk1, Mak-v
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347352
    NCBI Gene: 26559
Location & Maps
more
  • Sequence Map
    Chr16:90386397-90499553 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113157 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 51.71 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HUNK, hormonally up-regulated Neu-associated kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HUNK, hormonally up-regulated Neu-associated kinase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 30811
    neXtProt AC: NX_P57058

  • Chr Location
    21q22.1; chr21:31873315-32004064 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8742
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: HUNK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
  • All Mutations and Alleles
    26
  • Gene trapped
    16
  • Targeted
    10
  • Genomic Mutations
    6 involving Hunk
  • Incidental Mutations
Mutations in this gene result in no abnormal phenotype, however in combination with Tg(MMTV-Myc)Led mice, metastatic potential of mammary tumors is decreased.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053414 Ensembl Gene Model | MGI Sequence Detail 113157 C57BL/6J ±  kb
transcript ENSMUST00000065856 Ensembl | MGI Sequence Detail 5009 Not Applicable  
polypeptide ENSMUSP00000068007 Ensembl | MGI Sequence Detail 714 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    987 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008842 hormonally up-regulated neu tumor-associated kinase
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 71
    cDNA 69
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:44157 Chodosh LA, et al., Mammary gland development, reproductive history, and breast cancer risk. Cancer Res. 1999 Apr 1;59(7 Suppl):1765-1771s; discussion 1771s-1
  • Latest
    J:196198 Yeh ES, et al., Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6103-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory