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Ncdn Gene Detail
Summary
  • Symbol
    Ncdn
  • Name
    neurochondrin
  • Synonyms
    mKIAA0607, neurochondrin-1, neurochondrin-2, norbin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347351
    NCBI Gene: 26562
  • Gene Overview
    MyGene.info: NCDN
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126743750-126753438 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 60.93 cM, cytoband D2.1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347351
protein coding gene Chr4:126743750-126753637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028787
protein coding gene Chr4:128454255-128465317 (-)
A/J MGP_AJ_G0028746
protein coding gene Chr4:123392426-123402654 (-)
AKR/J MGP_AKRJ_G0028699
protein coding gene Chr4:126779477-126789010 (-)
BALB/cJ MGP_BALBcJ_G0028769
protein coding gene Chr4:123965009-123975083 (-)
C3H/HeJ MGP_C3HHeJ_G0028483
protein coding gene Chr4:126854683-126865313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029211
protein coding gene Chr4:133342707-133352474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026484
protein coding gene Chr4:116522771-116532530 (-)
CAST/EiJ MGP_CASTEiJ_G0027916
protein coding gene Chr4:124967270-124976920 (-)
CBA/J MGP_CBAJ_G0028449
protein coding gene Chr4:136567125-136576839 (-)
DBA/2J MGP_DBA2J_G0028598
protein coding gene Chr4:123837977-123847868 (-)
FVB/NJ MGP_FVBNJ_G0028565
protein coding gene Chr4:122495410-122505502 (-)
LP/J MGP_LPJ_G0028699
protein coding gene Chr4:128733174-128743657 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028591
protein coding gene Chr4:141584177-141596790 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029249
protein coding gene Chr4:127145830-127155481 (-)
PWK/PhJ MGP_PWKPhJ_G0027637
protein coding gene Chr4:120336109-120345827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027463
protein coding gene Chr4:122973437-122983070 (-)
WSB/EiJ MGP_WSBEiJ_G0027996
protein coding gene Chr4:127255926-127265643 (-)



Homology
more
  • Human Ortholog
    NCDN, neurochondrin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCDN, neurochondrin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23154
    neXtProt AC: NX_Q9UBB6
    UniProt: Q9UBB6

  • Chr Location
    1p34.3; chr1:35557792-35566779 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8064
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NCDN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene results in early embryonic lethality in the homozygous state and impaired chondrocyte proliferation and differentiation in the heterozygous state. Gene trap mutation resulted in lacrimal gland hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028833 Ensembl Gene Model | MGI Sequence Detail 9689 C57BL/6J ±  kb
    transcript ENSMUST00000030637 Ensembl | MGI Sequence Detail 3681 Not Applicable  
    polypeptide ENSMUSP00000030637 Ensembl | MGI Sequence Detail 729 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140483
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:54929 Ishiduka Y, et al., Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin. Biochim Biophys Acta. 1999 May 6;1450(1):92-8
    • Latest
      J:226063 Wang H, et al., Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9745-50

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory