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Ncdn Gene Detail
Summary
  • Symbol
    Ncdn
  • Name
    neurochondrin
  • Synonyms
    mKIAA0607, neurochondrin-1, neurochondrin-2, norbin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347351
    NCBI Gene: 26562
  • Gene Overview
    MyGene.info: NCDN
Location & Maps
more
  • Sequence Map
    Chr4:126743750-126753438 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9689 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 60.93 cM, cytoband D2.1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NCDN, neurochondrin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCDN, neurochondrin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23154
    neXtProt AC: NX_Q9UBB6

  • Chr Location
    1p34.3; chr1:35557792-35566779 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8064
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NCDN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Ncdn
  • Incidental Mutations
Targeted inactivation of this gene results in early embryonic lethality in the homozygous state and impaired chondrocyte proliferation and differentiation in the heterozygous state. Gene trap mutation resulted in lacrimal gland hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009274 VEGA Gene Model | MGI Sequence Detail 9689 C57BL/6J ±  kb
transcript OTTMUST00000021025 VEGA | MGI Sequence Detail 3681 Not Applicable  
polypeptide OTTMUSP00000009636 VEGA | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140483
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:54929 Ishiduka Y, et al., Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin. Biochim Biophys Acta. 1999 May 6;1450(1):92-8
  • Latest
    J:226063 Wang H, et al., Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9745-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory