Adamts6 MGI Mouse Gene Detail - MGI:1347348 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6

Symbol

Adamts6
Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
Synonyms

A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo

Feature Type

protein coding gene
IDs

MGI:1347348
NCBI Gene: 108154
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr13:104287835-104496695 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 56.42 cM
Mapping Data

2 experiments

SNPs within 2kb

1561 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347348	protein coding gene	Chr13:104287348-104496695 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0020908	protein coding gene	Chr13:106381686-106602876 (+)
A/J	MGP_AJ_G0020859	protein coding gene	Chr13:102237946-102448261 (+)
AKR/J	MGP_AKRJ_G0020834	protein coding gene	Chr13:105353320-105567563 (+)
BALB/cJ	MGP_BALBcJ_G0020859	protein coding gene	Chr13:102957184-103166061 (+)
C3H/HeJ	MGP_C3HHeJ_G0020648	protein coding gene	Chr13:105096901-105310036 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021293	protein coding gene	Chr13:109594727-109817367 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018863	protein coding gene	Chr13:97847260-98047246 (+)
CAST/EiJ	MGP_CASTEiJ_G0020167	protein coding gene	Chr13:104575651-104802917 (+)
CBA/J	MGP_CBAJ_G0020610	protein coding gene	Chr13:113834080-114066672 (+)
DBA/2J	MGP_DBA2J_G0020734	protein coding gene	Chr13:102011273-102217804 (+)
FVB/NJ	MGP_FVBNJ_G0020716	protein coding gene	Chr13:100703667-100913631 (+)
LP/J	MGP_LPJ_G0020808	protein coding gene	Chr13:106407660-106627501 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020744	protein coding gene	Chr13:114062875-114333044 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021332	protein coding gene	Chr13:104829898-105045058 (+)
PWK/PhJ	MGP_PWKPhJ_G0019920	protein coding gene	Chr13:100744033-100960759 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019742	protein coding gene	Chr13:101021410-101241781 (+)
WSB/EiJ	MGP_WSBEiJ_G0020225	protein coding gene	Chr13:105299614-105517088 (+)

Human Ortholog

ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6

Vertebrate Orthologs

10

Human Ortholog

ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
Orthology source: HomoloGene, HGNC
Synonyms

ADAM-TS6, ADAM-TS 6, ADAMTS-6
Links

HGNC:222

NCBI Gene ID: 11174

neXtProt AC: NX_Q9UKP5

UniProt: Q9UKP5
Chr Location

5q12.3; chr5:65148736-65482014 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 82573
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ADAMTS6
Gene Tree

Adamts6

less

Phenotype Summary

17 phenotypes from 9 alleles in 9 genetic backgrounds
139 images
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

9
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate.

less

All GO Annotations

4
GO References

1

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Assay Results

1
Tissues

1
cDNA Data

31
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADAMTS6

Xenbase adamts6

ZFIN adamts6

less

Adamts6 interacts with 295 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

less

All Sequences

58
RefSeq

11
UniProt

5
CCDS

CCDS36773.1
UniGene

208125

Ensembl

ENSMUSG00000046169 (Evidence)
NCBI Gene

108154

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046169	Ensembl Gene Model \| MGI Sequence Detail	208861	C57BL/6J	± kb
transcript	ENSMUST00000224208	Ensembl \| MGI Sequence Detail	6480	Not Applicable
polypeptide	ENSMUSP00000153359	Ensembl \| MGI Sequence Detail	1117	Not Applicable

less

UniProt

5 Sequences
InterPro Domains

IPR010294 ADAM-TS Spacer 1

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR010909 PLAC

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

less

All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 3

less

MGI:2444985, MGI:5476177, MGI:5487285, MGI:5491167, MGI:5491169, MGI:5547739

Summaries

All 24

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 5
Earliest

J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
Latest

J:242224 Haller M, et al., Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A. 2017 May 09;114(19):4981-4986

TSS for Adamts6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120915	Chr13:104287033-104287062 (+)	-787 bp
Tssr120916	Chr13:104287089-104287107 (+)	-737 bp
Tssr120917	Chr13:104287118-104287132 (+)	-710 bp
Tssr120918	Chr13:104287136-104287147 (+)	-693 bp
Tssr120919	Chr13:104287357-104287379 (+)	-467 bp
Tssr120920	Chr13:104287452-104287466 (+)	-376 bp
Tssr120921	Chr13:104287491-104287498 (+)	-340 bp
Tssr120922	Chr13:104287508-104287524 (+)	-319 bp
Tssr120923	Chr13:104287855-104287882 (+)	34 bp
Tssr120924	Chr13:104287902-104287923 (+)	78 bp
Tssr120925	Chr13:104287932-104287962 (+)	112 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13