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Adamts6 Gene Detail
Summary
  • Symbol
    Adamts6
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
  • Synonyms
    A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347348
    NCBI Gene: 108154
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:104424343-104633203 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347348
 protein coding gene Chr13:104423026-104633203 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020908
 protein coding gene Chr13:106381686-106602876 (+)
A/J MGP_AJ_G0020859
 protein coding gene Chr13:102237946-102448261 (+)
AKR/J MGP_AKRJ_G0020834
 protein coding gene Chr13:105353320-105567563 (+)
BALB/cJ MGP_BALBcJ_G0020859
 protein coding gene Chr13:102957184-103166061 (+)
C3H/HeJ MGP_C3HHeJ_G0020648
 protein coding gene Chr13:105096901-105310036 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021293
 protein coding gene Chr13:109594727-109817367 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018863
 protein coding gene Chr13:97847260-98047246 (+)
CAST/EiJ MGP_CASTEiJ_G0020167
 protein coding gene Chr13:104575651-104802917 (+)
CBA/J MGP_CBAJ_G0020610
 protein coding gene Chr13:113834080-114066672 (+)
DBA/2J MGP_DBA2J_G0020734
 protein coding gene Chr13:102011273-102217804 (+)
FVB/NJ MGP_FVBNJ_G0020716
 protein coding gene Chr13:100703667-100913631 (+)
LP/J MGP_LPJ_G0020808
 protein coding gene Chr13:106407660-106627501 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020744
 protein coding gene Chr13:114062875-114333044 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021332
 protein coding gene Chr13:104829898-105045058 (+)
PWK/PhJ MGP_PWKPhJ_G0019920
 protein coding gene Chr13:100744033-100960759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019742
 protein coding gene Chr13:101021410-101241781 (+)
WSB/EiJ MGP_WSBEiJ_G0020225
 protein coding gene Chr13:105299614-105517088 (+)



Homology
more
  • Human Ortholog
    ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
  • Synonyms
    ADAM-TS6, ADAM-TS 6, ADAMTS-6
  • Links
    NCBI Gene ID: 11174
    neXtProt AC: NX_Q9UKP5
    UniProt: Q9UKP5

  • Chr Location
    5q12.3; chr5:65148736-65482014 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 10 alleles in 10 genetic backgrounds
    139 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    1
  • cDNA Data
    31
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046169 Ensembl Gene Model | MGI Sequence Detail 208861 C57BL/6J ±  kb
    transcript ENSMUST00000224208 Ensembl | MGI Sequence Detail 6480 Not Applicable  
    polypeptide ENSMUSP00000153359 Ensembl | MGI Sequence Detail 1117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR013273 ADAMTS/ADAMTS-like
      IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3
      IPR010294 ADAMTS/ADAMTS-like, Spacer 1
      IPR041645 ADAMTS, cysteine-rich domain 2
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR002870 Peptidase M12B, propeptide
      IPR010909 PLAC
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444985, MGI:5476177, MGI:5487285, MGI:5491167, MGI:5491169, MGI:5547739
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
    • Latest
      J:324217 Mead TJ, et al., Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development. Elife. 2022 May 3;11:e71142
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/23/2022
    MGI 6.20     		The Jackson Laboratory