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Adamts6 Gene Detail
Summary
  • Symbol
    Adamts6
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
  • Synonyms
    A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347348
    NCBI Gene: 108154
Location & Maps
more
  • Sequence Map
    Chr13:104287873-104494763 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      206891 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.42 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM-TS6, ADAM-TS 6, ADAMTS-6
  • Links
    NCBI Gene ID: 11174
    neXtProt AC: NX_Q9UKP5
    UniProt: Q9UKP5

  • Chr Location
    5q12.3; chr5:65148736-65482014 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 9 alleles in 9 genetic backgrounds
    139 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    30
  • Literature Summary
    2
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046169 Ensembl Gene Model | MGI Sequence Detail 206891 C57BL/6J ±  kb
transcript ENSMUST00000065766 Ensembl | MGI Sequence Detail 4822 Not Applicable  
polypeptide ENSMUSP00000064570 Ensembl | MGI Sequence Detail 1117 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1539 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 30
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2444985, MGI:5476177, MGI:5487285, MGI:5491167, MGI:5491169, MGI:5547739
References
more
  • Summaries
    All 21
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
  • Latest
    J:231949 San Agustin JT, et al., Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016;7:11103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/13/2017
MGI 6.10 		The Jackson Laboratory