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Adamts6 Gene Detail
Summary
  • Symbol
    Adamts6
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
  • Synonyms
    A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347348
    NCBI Gene: 108154
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:104287835-104496695 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      208861 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS6, ADAM metallopeptidase with thrombospondin type 1 motif 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM-TS6, ADAM-TS 6, ADAMTS-6
  • Links
    NCBI Gene ID: 11174
    neXtProt AC: NX_Q9UKP5
    UniProt: Q9UKP5

  • Chr Location
    5q12.3; chr5:65148736-65482014 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 9 alleles in 9 genetic backgrounds
    139 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for induced mutations exhibit cardiovascular defects including double outlet right ventricle, ventricular septal defects and biventricular hypertrophy, and hydrops, thymus hypoplasia short snout and cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046169 Ensembl Gene Model | MGI Sequence Detail 208861 C57BL/6J ±  kb
    transcript ENSMUST00000224208 Ensembl | MGI Sequence Detail 6480 Not Applicable  
    polypeptide ENSMUSP00000153359 Ensembl | MGI Sequence Detail 1117 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1561 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR010294 ADAM-TS Spacer 1
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR002870 Peptidase M12B, propeptide
      IPR010909 PLAC
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444985, MGI:5476177, MGI:5487285, MGI:5491167, MGI:5491169, MGI:5547739
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 5
    • Earliest
      J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
    • Latest
      J:242224 Haller M, et al., Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A. 2017 May 09;114(19):4981-4986
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory