Slc27a4
Gene Detail

Symbol Name ID

Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 MGI:1347347

Synonyms

FATP4, fatty acid transport protein 4

Feature Type

protein coding gene

Genetic Map

Chromosome 2

20.64 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:29802634-29817522 bp, + strand From VEGA annotation of GRCm38   14889 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc27a4

Human homologs

Human Homolog		SLC27A4, solute carrier family 27 (fatty acid transporter), member 4
NCBI Gene ID		10999
neXtProt AC		NX_Q6P1M0
Human Synonyms		ACSVL4, FATP4, IPS
Human Chr (Location)		9q34.11; chr9:131102839-131123749 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC27A4

Alleles and phenotypes

All alleles(13) : Targeted(9) Gene trapped(2) Spontaneous(2)
 

Homozygous mutant mice are not viable. While mice of one mutant line die during early development, mice of other mutant lines die at birth exhibiting abnormal skin.

 
Human Diseases Modeled Using Mouse Slc27a4 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	fatty acid metabolic process, lipid metabolic process, ...
Component	brush border membrane, endoplasmic reticulum, ...
Function	catalytic activity, ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (102)    Tissues (102)    Images (7)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	8

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) Genomic(1) cDNA(73) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000012688 (Evidence)
Ensembl Gene Model	ENSMUSG00000059316 (Evidence)
Entrez Gene	26569 (Evidence)
UniGene	330113
DFCI	TC1576419
DoTS	DT.530666
NIA Mouse Gene Index	U001562
EC	6.2.1.-
Consensus CDS Project	CCDS15858.1
International Mouse Knockout Project Status	Slc27a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012688	VEGA Gene Model | MGI Sequence Detail	14889	C57BL/6J
transcript	OTTMUST00000030248	VEGA | MGI Sequence Detail	4054	Not Applicable
polypeptide	OTTMUSP00000013611	VEGA | MGI Sequence Detail	643	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020845	AMP-binding, conserved site
InterPro	IPR000873	AMP-dependent synthetase/ligase
InterPro	IPR022272	Lipocalin conserved site
Protein Ontology	PR:000015048	long-chain fatty acid transport protein 4

References

(Earliest) J:42634 Hirsch D, et al., A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8625-9
(Latest) J:194257 Li S, et al., Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase. J Neurosci. 2013 Feb 13;33(7):3178-89
All references(60)

Other accession IDs

MGI:2139436