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Adamts7 Gene Detail
Summary
  • Symbol
    Adamts7
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
  • Synonyms
    ADAM-TS7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347346
    NCBI Gene: 108153
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:90162904-90200102 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 47.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347346
protein coding gene Chr9:90162904-90208071 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035121
protein coding gene Chr9:91105445-91155685 (+)
A/J MGP_AJ_G0035102
protein coding gene Chr9:87953362-87998206 (+)
AKR/J MGP_AKRJ_G0035034
protein coding gene Chr9:90026403-90071195 (+)
BALB/cJ MGP_BALBcJ_G0035094
protein coding gene Chr9:87609392-87654943 (+)
C3H/HeJ MGP_C3HHeJ_G0034805
protein coding gene Chr9:90476896-90523096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035615
protein coding gene Chr9:93651139-93706081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032518
protein coding gene Chr9:86126597-86172483 (+)
CAST/EiJ MGP_CASTEiJ_G0034117
protein coding gene Chr9:90253312-90300782 (+)
CBA/J MGP_CBAJ_G0034773
protein coding gene Chr9:96901021-96950504 (+)
DBA/2J MGP_DBA2J_G0034935
protein coding gene Chr9:87501300-87546231 (+)
FVB/NJ MGP_FVBNJ_G0034881
protein coding gene Chr9:86527726-86572665 (+)
LP/J MGP_LPJ_G0035014
protein coding gene Chr9:91342840-91392115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034922
protein coding gene Chr9:98512548-98558312 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035635
protein coding gene Chr9:90253037-90298826 (+)
PWK/PhJ MGP_PWKPhJ_G0033824
protein coding gene Chr9:87677305-87723053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033658
protein coding gene Chr9:90322027-90366626 (+)
WSB/EiJ MGP_WSBEiJ_G0034237
protein coding gene Chr9:90139503-90185596 (+)



Homology
more
  • Human Ortholog
    ADAMTS7, ADAM metallopeptidase with thrombospondin type 1 motif 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAMTS7, ADAM metallopeptidase with thrombospondin type 1 motif 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM-TS7, ADAM-TS 7, ADAMTS-7
  • Links
    NCBI Gene ID: 11173
    neXtProt AC: NX_Q9UKP4
    UniProt: Q9UKP4

  • Chr Location
    15q25.1; chr15:78759203-78811464 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased lung function parameters, reduced endothelial cell migration and proliferation, increased re-endothelialization and ameliorated neointima formation after carotid artery injury, and increased oval cell activation and biliary fibrosis after liver injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108153 NCBI Gene Model | MGI Sequence Detail 37199 C57BL/6J ±  kb
transcript NM_001326351 RefSeq | MGI Sequence Detail 5496 Not Specified  
polypeptide Q68SA9 UniProt | EBI | MGI Sequence Detail 1657 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 42
    cDNA 39
    Primer pair 1
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
  • Latest
    J:264139 Mead TJ, et al., The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification. JCI Insight. 2018 Apr 5;3(7)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory