Homer1
Gene Detail

Symbol Name ID

Homer1 homer homolog 1 (Drosophila) MGI:1347345

Synonyms

PSD-Zip45, Ves-1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

47.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:93303757-93404129 bp, + strand From VEGA annotation of GRCm38   100373 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3155  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Homer1

Human homologs

Human Homolog		HOMER1, homer homolog 1 (Drosophila)
NCBI Gene ID		9456
neXtProt AC		NX_Q86YM7
Human Synonyms		HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Human Chr (Location)		5q14.2; chr5:78669786-78809700 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous mutants exhibit an increase in spontaneous calcium influx in pancreatic acinar cells. Mice homozygous for a knock-out allele exhibit decreased response to formalin-induced pain.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	behavioral response to cocaine, chemical homeostasis within a tissue, ...
Component	apical part of cell, cell junction, ...
Function	ion channel binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (121)    Images (29)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	121

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016339 (Evidence)
Ensembl Gene Model	ENSMUSG00000007617 (Evidence)
Entrez Gene	26556 (Evidence)
DFCI	TC1582088, TC1586250, TC1593866, TC1663131
NIA Mouse Gene Index	U015115
Consensus CDS Project	CCDS26687.1, CCDS36745.1, CCDS36746.1
International Mouse Knockout Project Status	Homer1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016339	VEGA Gene Model | MGI Sequence Detail	100373	C57BL/6J
transcript	OTTMUST00000047893	VEGA | MGI Sequence Detail	3287	Not Applicable
polypeptide	OTTMUSP00000021811	VEGA | MGI Sequence Detail	370	Not Applicable

All sequences(79) RefSeq(6) UniProt(9)

Polymorphisms

SNPs(317 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000697	EVH1
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000008678	homer protein 1

References

(Earliest) J:50718 Xiao B, et al., Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 Oct;21(4):707-16
(Latest) J:191366 Hu JH, et al., Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012 Jun;15(6):836-44
All references(54)