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Homer1 Gene Detail
Summary
  • Symbol
    Homer1
  • Name
    homer scaffolding protein 1
  • Synonyms
    PSD-Zip45, Ves-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347345
    NCBI Gene: 26556
  • Gene Overview
    MyGene.info: HOMER1
Location & Maps
more
  • Sequence Map
    Chr13:93303757-93404129 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100373 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.83 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HOMER1, homer scaffolding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HOMER1, homer scaffolding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
  • Links
    NCBI Gene ID: 9456
    neXtProt AC: NX_Q86YM7

  • Chr Location
    5q14.2; chr5:79373824-79513836 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3155
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: HOMER1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Homer1
  • Incidental Mutations
Homozygous mutants exhibit an increase in spontaneous calcium influx in pancreatic acinar cells. Mice homozygous for a knock-out allele exhibit decreased response to formalin-induced pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016339 VEGA Gene Model | MGI Sequence Detail 100373 C57BL/6J ±  kb
transcript OTTMUST00000047893 VEGA | MGI Sequence Detail 3287 Not Applicable  
polypeptide OTTMUSP00000021811 VEGA | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    363 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008678 homer protein homolog 1
  • InterPro Domains
    IPR011993 PH domain-like
    IPR019394 Testis-specific protein TEX28/transmembrane and coiled-coil domains protein
    IPR000697 WH1/EVH1 domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 34
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 67
    Developmental Gene Expression 4
    Gene Ontology 17
    Phenotypes 23
  • Earliest
    J:50718 Xiao B, et al., Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 Oct;21(4):707-16
  • Latest
    J:227676 Serchov T, et al., Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Neuron. 2015 Aug 5;87(3):549-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory