About   Help   FAQ
Homer1
Gene Detail
Symbol

Name
ID
Homer1
homer homolog 1 (Drosophila)
MGI:1347345
Synonyms
PSD-Zip45, Ves-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
47.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:93303757-93404129 bp, + strand
From VEGA annotation of GRCm38

  100373 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Homer1

Human
homologs
Human Homolog HOMER1, homer homolog 1 (Drosophila)
NCBI Gene ID 9456
neXtProt AC  NX_Q86YM7
Human Synonyms  HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
Human Chr (Location)  5q14.2; chr5:79373824-79513836 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit an increase in spontaneous calcium influx in pancreatic acinar cells. Mice homozygous for a knock-out allele exhibit decreased response to formalin-induced pain.
 
Interactions
Homer1 interacts with 457 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process behavioral response to cocaine, chemical homeostasis within a tissue, ...
Component apical part of cell, axon, ...
Function G-protein coupled glutamate receptor binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (121)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(34)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(34) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016339 (Evidence)
Ensembl Gene ModelENSMUSG00000007617 (Evidence)
Entrez Gene26556 (Evidence)
UniGene37533
DFCITC1586250, TC1582088, TC1593866, TC1663131
NIA Mouse Gene IndexU015115
Consensus CDS ProjectCCDS26687.1, CCDS36745.1, CCDS36746.1, CCDS70484.1
International Mouse Knockout Project StatusHomer1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016339 VEGA Gene Model | MGI Sequence Detail 100373 C57BL/6J ±  kb
transcript OTTMUST00000047893 VEGA | MGI Sequence Detail 3287 Not Applicable 
polypeptide OTTMUSP00000021811 VEGA | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(10) UniProt(17)
Polymorphisms
SNPs within 2kb(366 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000008678 homer protein homolog 1
References
(Earliest) J:50718 Xiao B, et al., Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 Oct;21(4):707-16
(Latest) J:212333 Wagner KV, et al., Hippocampal Homer1 levels influence motivational behavior in an operant conditioning task. PLoS One. 2014;9(1):e85975
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory