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Usp5 Gene Detail
Summary
  • Symbol
    Usp5
  • Name
    ubiquitin specific peptidase 5 (isopeptidase T)
  • Synonyms
    Ucht
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347343
    NCBI Gene: 22225
  • Gene Overview
    MyGene.info: USP5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124815019-124829484 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347343
protein coding gene Chr6:124815019-124829484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031270
protein coding gene Chr6:128121806-128136271 (-)
A/J MGP_AJ_G0031240
protein coding gene Chr6:123301296-123315761 (-)
AKR/J MGP_AKRJ_G0031168
protein coding gene Chr6:126666482-126680947 (-)
BALB/cJ MGP_BALBcJ_G0031248
protein coding gene Chr6:122900970-122915435 (-)
C3H/HeJ MGP_C3HHeJ_G0030971
protein coding gene Chr6:126713623-126728088 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031704
protein coding gene Chr6:131505396-131519861 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028854
protein coding gene Chr6:120511315-120525979 (-)
CAST/EiJ MGP_CASTEiJ_G0030352
protein coding gene Chr6:126917416-126931848 (-)
CBA/J MGP_CBAJ_G0030932
protein coding gene Chr6:136536932-136551397 (-)
DBA/2J MGP_DBA2J_G0031088
protein coding gene Chr6:122227828-122242293 (-)
FVB/NJ MGP_FVBNJ_G0031038
protein coding gene Chr6:121130137-121144602 (-)
LP/J MGP_LPJ_G0031168
protein coding gene Chr6:128292595-128307060 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031076
protein coding gene Chr6:140596107-140610572 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031739
protein coding gene Chr6:126559377-126573842 (-)
PWK/PhJ MGP_PWKPhJ_G0030067
protein coding gene Chr6:120458741-120473113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029896
protein coding gene Chr6:124640013-124657080 (-)
WSB/EiJ MGP_WSBEiJ_G0030437
protein coding gene Chr6:126918344-126932819 (-)



Homology
more
  • Human Ortholog
    USP5, ubiquitin specific peptidase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP5, ubiquitin specific peptidase 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ISOT
  • Links
    NCBI Gene ID: 8078
    neXtProt AC: NX_P45974
    UniProt: P45974

  • Chr Location
    12p13.31; chr12:6852118-6866632 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22225 NCBI Gene Model | MGI Sequence Detail 14466 C57BL/6J ±  kb
transcript NM_013700 RefSeq | MGI Sequence Detail 3233 C57BL/6  
polypeptide P56399 UniProt | EBI | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 212
    Genomic 3
    cDNA 209

    Microarray probesets 2
Other
Accession IDs
less
MGI:1315191, MGI:2141357
References
more
  • Summaries
    All 39
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
  • Latest
    J:241711 Stemkowski P, et al., TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity. Cell Rep. 2016 Dec 13;17(11):2901-2912

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory