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Ceacam2 Gene Detail
Summary
  • Symbol
    Ceacam2
  • Name
    carcinoembryonic antigen-related cell adhesion molecule 2
  • Synonyms
    Bgp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347246
    NCBI Gene: 26367
  • Member of
    Cea cluster
Location & Maps
more
  • Sequence Map
    Chr7:25516042-25539857 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23816 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CEACAM1, carcinoembryonic antigen related cell adhesion molecule 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CEACAM1, carcinoembryonic antigen related cell adhesion molecule 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BGP, BGP1, BGPI
  • Links
    NCBI Gene ID: 634
    neXtProt AC: NX_P13688

  • Chr Location
    19q13.2; chr19:42507306-42528509 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Gene trapped
    1
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit female-specific obesity, disruption in glucose homeostasis, hyperphagia, hyperinsulinemia and decreased energy expenditure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025351 VEGA Gene Model | MGI Sequence Detail 23816 C57BL/6J ±  kb
transcript OTTMUST00000062402 VEGA | MGI Sequence Detail 3140 Not Applicable  
polypeptide OTTMUSP00000030752 VEGA | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    236 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    Genomic 3
    cDNA 3
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-16441, MGI:2141896, MGI:99656
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:18755 Nedellec P, et al., Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. J Virol. 1994 Jul;68(7):4525-37
  • Latest
    J:218111 Alshahrani MM, et al., CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo. Blood. 2014 Oct 9;124(15):2431-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory