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Axl Gene Detail
Summary
  • Symbol
    Axl
  • Name
    AXL receptor tyrosine kinase
  • Synonyms
    Ark, Tyro7, Ufo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347244
    NCBI Gene: 26362
  • Gene Overview
    MyGene.info: AXL
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25757273-25788705 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.02 cM, cytoband A3-B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347244
 protein coding gene Chr7:25756500-25788733 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031879
 protein coding gene Chr7:24268749-24302400 (-)
A/J MGP_AJ_G0031858
 protein coding gene Chr7:23632680-23666366 (-)
AKR/J MGP_AKRJ_G0031787
 protein coding gene Chr7:24245617-24279736 (-)
BALB/cJ MGP_BALBcJ_G0031863
 protein coding gene Chr7:23872367-23903400 (-)
C3H/HeJ MGP_C3HHeJ_G0031584
 protein coding gene Chr7:24649124-24688759 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032327
 protein coding gene Chr7:25086863-25117712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029382
 protein coding gene Chr7:24972866-25004082 (-)
CAST/EiJ MGP_CASTEiJ_G0030924
 protein coding gene Chr7:18064204-18095040 (-)
CBA/J MGP_CBAJ_G0031549
 protein coding gene Chr7:25973943-26010042 (-)
DBA/2J MGP_DBA2J_G0031703
 protein coding gene Chr7:23526164-23559027 (-)
FVB/NJ MGP_FVBNJ_G0031656
 protein coding gene Chr7:23558490-23590543 (-)
LP/J MGP_LPJ_G0031782
 protein coding gene Chr7:24544599-24578563 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031693
 protein coding gene Chr7:25691967-25724112 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032359
 protein coding gene Chr7:23878557-23915328 (-)
PWK/PhJ MGP_PWKPhJ_G0030648
 protein coding gene Chr7:18479823-18519498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030478
 protein coding gene Chr7:15206991-15239324 (-)
WSB/EiJ MGP_WSBEiJ_G0031027
 protein coding gene Chr7:24102537-24134698 (-)



Homology
more
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARK, JTK11, Tyro7, UFO
  • Links
    NCBI Gene ID: 558
    neXtProt AC: NX_P30530
    UniProt: P30530

  • Chr Location
    19q13.2; chr19:41219199-41261767 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human AXL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    51 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    465
  • Tissues
    194
  • cDNA Data
    136
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002602 Ensembl Gene Model | MGI Sequence Detail 31433 C57BL/6J ±  kb
    transcript ENSMUST00000002677 Ensembl | MGI Sequence Detail 4265 Not Applicable  
    polypeptide ENSMUSP00000002677 Ensembl | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 136
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15343, MGI:2141908, MGI:98896
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 24
      Phenotypes 55
    • Earliest
      J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
    • Latest
      J:266906 Waterborg CEJ, et al., Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis. PLoS One. 2018;13(10):e0205902
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/11/2018
    MGI 6.13     		The Jackson Laboratory