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Axl Gene Detail
Summary
  • Symbol
    Axl
  • Name
    AXL receptor tyrosine kinase
  • Synonyms
    Ark, Tyro7, Ufo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347244
    NCBI Gene: 26362
  • Gene Overview
    MyGene.info: AXL
Location & Maps
more
  • Sequence Map
    Chr7:25757273-25788705 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      31433 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.02 cM, cytoband A3-B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARK, JTK11, Tyro7, UFO
  • Links
    NCBI Gene ID: 558
    neXtProt AC: NX_P30530
    UniProt: P30530

  • Chr Location
    19q13.2; chr19:41219199-41261767 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human AXL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    51 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    68
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    456
  • Tissues
    188
  • cDNA Data
    135
  • Literature Summary
    11
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022291 VEGA Gene Model | MGI Sequence Detail 31433 C57BL/6J ±  kb
transcript OTTMUST00000053091 VEGA | MGI Sequence Detail 4265 Not Applicable  
polypeptide OTTMUSP00000025228 VEGA | MGI Sequence Detail 888 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    122 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 137
    cDNA 135
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15343, MGI:2141908, MGI:98896
References
more
  • Summaries
    All 92
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 23
    Phenotypes 46
  • Earliest
    J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
  • Latest
    J:234960 Nowakowski TJ, et al., Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell Stem Cell. 2016 May 5;18(5):591-6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory