Axl
Gene Detail

Symbol Name ID

Axl AXL receptor tyrosine kinase MGI:1347244

Synonyms

Ark, Tyro7, Ufo

Feature Type

protein coding gene

Genetic Map

Chromosome 7

14.02 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:25757273-25788705 bp, - strand From VEGA annotation of GRCm38   31433 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: tyrosine-protein kinase receptor TYRO3/UFO/MER type
Gene Tree: Axl

Human homologs

Human Homolog		AXL, AXL receptor tyrosine kinase
NCBI Gene ID		558
neXtProt AC		NX_P30530
Human Synonyms		JTK11, UFO
Human Chr (Location)		19q13.1; chr19:41725108-41767671 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (64 annotations)

Process	apoptotic cell clearance, blood vessel remodeling, ...
Component	cell surface, extracellular space, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (459)    Tissues (189)    Images (154)
Theiler Stages: 3, 4, 13, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	208
In situ reporter (knock in)	188
Northern blot	8
RT-PCR	55

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(20) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022291 (Evidence)
Ensembl Gene Model	ENSMUSG00000002602 (Evidence)
Entrez Gene	26362 (Evidence)
DFCI	TC1574561, TC1576432, TC1580210, TC1686075
DoTS	DT.101227378, DT.101280926, DT.101358309, DT.101737745, DT.110978682, DT.495418, DT.91335793
NIA Mouse Gene Index	U028284
EC	2.7.10.1
Consensus CDS Project	CCDS20996.1, CCDS57528.1
International Mouse Knockout Project Status	Axl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022291	VEGA Gene Model | MGI Sequence Detail	31433	C57BL/6J
transcript	OTTMUST00000053091	VEGA | MGI Sequence Detail	4265	Not Applicable
polypeptide	OTTMUSP00000025228	VEGA | MGI Sequence Detail	888	Not Applicable

All sequences(65) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000004528	tyrosine-protein kinase receptor UFO

References

(Earliest) J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
(Latest) J:190898 Bauer T, et al., Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med. 2012 Oct 22;209(11):2033-47
All references(77)

Other accession IDs

MGD-MRK-15343, MGI:2141908, MGI:98896