Axl MGI Mouse Gene Detail - MGI:1347244 - AXL receptor tyrosine kinase

Axl Gene Detail

Symbol

Axl
Name

AXL receptor tyrosine kinase
Synonyms

Ark, Tyro7, Ufo

Feature Type

protein coding gene
IDs

MGI:1347244
NCBI Gene: 26362
Gene Overview

MyGene.info: AXL

Sequence Map

Chr7:25757273-25788705 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

31433 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 14.02 cM, cytoband A3-B1
Mapping Data

3 experiments

Human Ortholog

AXL, AXL receptor tyrosine kinase

Vertebrate Orthologs

7

Human Ortholog

AXL, AXL receptor tyrosine kinase
Orthology source: HomoloGene, HGNC
Synonyms

ARK, JTK11, Tyro7, UFO
Links

HGNC:905

NCBI Gene ID: 558

neXtProt AC: NX_P30530
Chr Location

19q13.1; chr19:41219199-41261767 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 7583
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed
HCOP

human homology predictions: AXL
Protein SuperFamily

tyrosine-protein kinase receptor TYRO3/UFO/MER type
Gene Tree

Axl

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Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
51 phenotypes from multigenic genotypes
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.

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All GO Annotations

69
GO References

23

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

456
Tissues

188
cDNA Data

135
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase axl

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Axl interacts with 210 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

62
RefSeq

14
UniProt

5
CCDS

CCDS20996.1, CCDS57528.1
UniGene

4128

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022291	VEGA Gene Model \| MGI Sequence Detail	31433	C57BL/6J	± kb
transcript	OTTMUST00000053091	VEGA \| MGI Sequence Detail	4265	Not Applicable
polypeptide	OTTMUSP00000025228	VEGA \| MGI Sequence Detail	888	Not Applicable

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SNPs within 2kb

122 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000004528 tyrosine-protein kinase receptor UFO
EC

2.7.10.1
InterPro Domains

IPR003961 Fibronectin type III

IPR007110 Immunoglobulin-like domain

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

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All nucleic 137

cDNA 135

Primer pair 2

Microarray probesets 3

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MGD-MRK-15343, MGI:2141908, MGI:98896

Summaries

All 90

Developmental Gene Expression 10

Diseases 2

Gene Ontology 23

Phenotypes 45
Earliest

J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
Latest

J:232484 Chan PY, et al., The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science. 2016 Apr 1;352(6281):99-103

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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