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Axl
Gene Detail
Symbol

Name
ID
Axl
AXL receptor tyrosine kinase
MGI:1347244
Synonyms
Ark, Tyro7, Ufo
Feature Type
protein coding gene
Genetic Map
Chromosome 7
14.02 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:25757273-25788705 bp, - strand
From VEGA annotation of GRCm38

  31433 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: AXL
Protein SuperFamily: tyrosine-protein kinase receptor TYRO3/UFO/MER type
Gene Tree: Axl

Human
homologs
AXL, AXL receptor tyrosine kinase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 558
neXtProt AC: NX_P30530

Human Synonyms: ARK, JTK11, Tyro7, UFO

Human Chr (Location): 19q13.1; chr19:41219199-41261767 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Axl interacts with 210 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process apoptotic cell clearance, blood vessel remodeling, ...
Component cell, cell surface, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (456)    Tissues (186)    Images (154)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 208
In situ reporter (knock in) 188
Northern blot 8
RT-PCR 52
cDNA source data(135)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase axl    NEW 
Molecular
reagents
All nucleic(137) cDNA(135) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022291 (Evidence)
Ensembl Gene Model ENSMUSG00000002602 (Evidence)
Entrez Gene 26362 (Evidence)
UniGene 4128
DFCI TC1574561, TC1686075, TC1580210, TC1576432
DoTS DT.101280926, DT.101227378, DT.101358309, DT.101737745, DT.91335793, DT.110978682, DT.495418
NIA Mouse Gene Index U028284
EC 2.7.10.1
Consensus CDS Project CCDS20996.1, CCDS57528.1
International Mouse Phenotyping Consortium Status Axl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022291 VEGA Gene Model | MGI Sequence Detail 31433 C57BL/6J ±  kb
transcript OTTMUST00000053091 VEGA | MGI Sequence Detail 4265 Not Applicable 
polypeptide OTTMUSP00000025228 VEGA | MGI Sequence Detail 888 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(16) UniProt(5)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000004528 tyrosine-protein kinase receptor UFO
References
(Earliest) J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
(Latest) J:219034 Hyde GD, et al., Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia. PLoS One. 2014;9(7):e102096
All references(89)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15343, MGI:2141908, MGI:98896

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory