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Axl Gene Detail
Summary
  • Symbol
    Axl
  • Name
    AXL receptor tyrosine kinase
  • Synonyms
    Ark, Tyro7, Ufo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347244
    NCBI Gene: 26362
  • Gene Overview
    MyGene.info: AXL
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:25757273-25788705 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      31433 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.02 cM, cytoband A3-B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARK, JTK11, Tyro7, UFO
  • Links
    NCBI Gene ID: 558
    neXtProt AC: NX_P30530
    UniProt: P30530

  • Chr Location
    19q13.2; chr19:41219199-41261767 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human AXL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    51 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    465
  • Tissues
    194
  • cDNA Data
    136
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022291 VEGA Gene Model | MGI Sequence Detail 31433 C57BL/6J ±  kb
    transcript OTTMUST00000053091 VEGA | MGI Sequence Detail 4265 Not Applicable  
    polypeptide OTTMUSP00000025228 VEGA | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      122 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 136
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15343, MGI:2141908, MGI:98896
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 23
      Phenotypes 53
    • Earliest
      J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
    • Latest
      J:264516 Ayata P, et al., Epigenetic regulation of brain region-specific microglia clearance activity. Nat Neurosci. 2018 Aug;21(8):1049-1060
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory