Slc27a2 MGI Mouse Gene Detail - MGI:1347099 - solute carrier family 27 (fatty acid transporter), member 2

Slc27a2 Gene Detail

Symbol

Slc27a2
Name

solute carrier family 27 (fatty acid transporter), member 2
Synonyms

ACSVL1, FATP2, FATP2, Vlac, Vlacs, VLCS

Feature Type

protein coding gene
IDs

MGI:1347099
NCBI Gene: 26458
Gene Overview

MyGene.info: SLC27A2

Sequence Map

Chr2:126552407-126588243 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

35837 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

3 experiments

Human Ortholog

SLC27A2, solute carrier family 27 member 2

Vertebrate Orthologs

11

Human Ortholog

SLC27A2, solute carrier family 27 member 2
Orthology source: HomoloGene, HGNC
Synonyms

ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, VLACS, VLCS
Links

HGNC:10996

NCBI Gene ID: 11001

neXtProt AC: NX_O14975
Chr Location

15q21.2; chr15:50182196-50236392 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 37830
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SLC27A2
Gene Tree

Slc27a2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Slc27a2
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygous mutant mice are viable and show no gross morphological abnormalities.

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All GO Annotations

78
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

357
Tissues

257
cDNA Data

173
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase slc27a2

ZFIN slc27a2a

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Slc27a2 interacts with 50 markers (Mir19a, Mir125a, Mir143, ...) View All

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All Sequences

32
RefSeq

2
UniProt

4
CCDS

CCDS16683.1
UniGene

290044

			Length	Strain/Species	Flank
genomic	OTTMUSG00000015755	VEGA Gene Model \| MGI Sequence Detail	35837	C57BL/6J	± kb
transcript	OTTMUST00000037419	VEGA \| MGI Sequence Detail	2918	Not Applicable
polypeptide	OTTMUSP00000016767	VEGA \| MGI Sequence Detail	620	Not Applicable

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SNPs within 2kb

342 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000015046 very long-chain acyl-CoA synthetase
EC

6.2.1.-, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme C-terminal domain

IPR000873 AMP-dependent synthetase/ligase

IPR030305 Fatty acid transport protein 2

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All nucleic 176

cDNA 173

Primer pair 3

Microarray probesets 3

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MGI:1330825

Summaries

All 48

Developmental Gene Expression 12

Gene Ontology 12

Phenotypes 10
Earliest

J:42534 Pirard M, et al., Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells. FEBS Lett. 1997 Jul 14;411(2-3):251-4
Latest

J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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