Slc27a2 MGI Mouse Gene Detail - MGI:1347099 - solute carrier family 27 (fatty acid transporter), member 2

Symbol

Slc27a2
Name

solute carrier family 27 (fatty acid transporter), member 2
Synonyms

ACSVL1, FATP2, FATP2, Vlac, Vlacs, VLCS

Feature Type

protein coding gene
IDs

MGI:1347099
NCBI Gene: 26458
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:126394944-126430163 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

3 experiments

SNPs within 2kb

1673 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347099	protein coding gene	Chr2:126394327-126430163 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026440	protein coding gene	Chr2:129769807-129811030 (+)
A/J	MGP_AJ_G0026403	protein coding gene	Chr2:124510387-124549574 (+)
AKR/J	MGP_AKRJ_G0026379	protein coding gene	Chr2:128085393-128123035 (+)
BALB/cJ	MGP_BALBcJ_G0026415	protein coding gene	Chr2:124781730-124820053 (+)
C3H/HeJ	MGP_C3HHeJ_G0026159	protein coding gene	Chr2:128563210-128599788 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026861	protein coding gene	Chr2:133905059-133941968 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024238	protein coding gene	Chr2:119244402-119280783 (+)
CAST/EiJ	MGP_CASTEiJ_G0025620	protein coding gene	Chr2:128787340-128831132 (+)
CBA/J	MGP_CBAJ_G0026139	protein coding gene	Chr2:138803808-138839645 (+)
DBA/2J	MGP_DBA2J_G0026273	protein coding gene	Chr2:123921636-123959691 (+)
FVB/NJ	MGP_FVBNJ_G0026237	protein coding gene	Chr2:122579548-122617364 (+)
LP/J	MGP_LPJ_G0026378	protein coding gene	Chr2:130031512-130071293 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026257	protein coding gene	Chr2:142879197-142921315 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026916	protein coding gene	Chr2:128097173-128134134 (+)
PWK/PhJ	MGP_PWKPhJ_G0025356	protein coding gene	Chr2:123468686-123505056 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025158	protein coding gene	Chr2:127169511-127210103 (+)
WSB/EiJ	MGP_WSBEiJ_G0025694	protein coding gene	Chr2:128987173-129026620 (+)

Human Ortholog

SLC27A2, solute carrier family 27 member 2

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC27A2, solute carrier family 27 member 2
Synonyms

ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, VLACS, VLCS
Links

HGNC:10996

NCBI Gene ID: 11001

UniProt: O14975
Chr Location

15q21.2; chr15:50182196-50236385 (+) GRCh38

MGI Vertebrate Homology

Slc27a2 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: SLC27A2
Gene Tree

Slc27a2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Slc27a2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Homozygous mutant mice are viable and show no gross morphological abnormalities.

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All GO Annotations

91
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1079
Tissues

262
cDNA Data

175
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc27a2

ZFIN slc27a2a

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All Sequences

43
RefSeq

2
UniProt

4
CCDS

CCDS16683.1

Ensembl

ENSMUSG00000027359 (Evidence)
NCBI Gene

26458

			Length	Strain/Species	Flank
genomic	26458	NCBI Gene Model \| MGI Sequence Detail	35220	C57BL/6J	± kb
transcript	NM_011978	RefSeq \| MGI Sequence Detail	2309	C57BL/6
polypeptide	O35488	UniProt \| EBI \| MGI Sequence Detail	620	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015046 long-chain fatty acid transport protein 2

(term hierarchy)
EC

6.2.1.-, 6.2.1.15, 6.2.1.24, 6.2.1.3, 6.2.1.7
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain
GlyGen

O35488 2 sites, 1 O-linked glycan (1 site)

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All nucleic 179

cDNA 175

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1330825

Summaries

All 71

Developmental Gene Expression 15

Gene Ontology 18

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:367303 He X, et al., Mechanism of valproic acid-induced hepatic steatosis via enhancing NRF2-FATP2-mediated fatty acid uptake. Theranostics. 2025;15(11):5258-5276

TSS for Slc27a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19938	Chr2:126394655-126394667 (+)	-283 bp
Tssr19939	Chr2:126394677-126394688 (+)	-261 bp
Tssr19940	Chr2:126394731-126394740 (+)	-208 bp
Tssr19941	Chr2:126394756-126394813 (+)	-159 bp
Tssr19942	Chr2:126394824-126394835 (+)	-114 bp
Tssr19943	Chr2:126394935-126394953 (+)	0 bp
Tssr19944	Chr2:126395500-126395518 (+)	565 bp
Tssr633	Chr2:126398442-126398452 (+)	3,503 bp
Tssr19945	Chr2:126403582-126403620 (+)	8,657 bp
Tssr19946	Chr2:126409663-126409674 (+)	14,725 bp
Tssr19947	Chr2:126410321-126410328 (+)	15,381 bp
Tssr19948	Chr2:126418719-126418730 (+)	23,781 bp
Tssr19949	Chr2:126419754-126419765 (+)	24,816 bp
Tssr19950	Chr2:126429733-126429743 (+)	34,794 bp
Tssr19951	Chr2:126430015-126430029 (+)	35,078 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24