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Slc27a1
Gene Detail
 Symbol
Name
ID
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
MGI:1347098
Synonyms Fatp, FATP1
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.43 cM, cytoband B3.3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:71568927-71586708 bp, + strand
From NCBI annotation of GRCm38

  17782 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc27a1

Human
homologs
Human Homolog SLC27A1, solute carrier family 27 (fatty acid transporter), member 1
NCBI Gene ID 376497
neXtProt AC  NX_Q6PCB7
Human Synonyms  ACSVL5, FATP, FATP1
Human Chr (Location)  19p13.11; chr19:17405703-17506168 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are protected from fat-induced insulin resistance and intramuscular accumulation of fatty acid metabolites without alterations in whole body adiposity.
 
Interactions
Slc27a1 interacts with 98 markers (Mir1b, Mir7-1, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process adiponectin-activated signaling pathway, cardiolipin biosynthetic process, ...
Component caveola, cytoplasm, ...
Function 2,4,4-trimethylpentanoate-CoA ligase activity, 2,4-dichlorobenzoate-CoA ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (501)    Tissues (155)    Images (63)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 493
Northern blot 8
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(3) cDNA(61) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031808 (Evidence)
Entrez Gene26457 (Evidence)
UniGene38165
DFCITC1582895, TC1683235
DoTSDT.101249717, DT.101353173, DT.110867865, DT.526863, DT.87055192
NIA Mouse Gene IndexU042913
EC6.2.1.-
Consensus CDS ProjectCCDS40386.1
International Mouse Knockout Project StatusSlc27a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26457 NCBI Gene Model | MGI Sequence Detail 17782 C57BL/6J ±  kb
transcript NM_011977 RefSeq | MGI Sequence Detail 2795 C57BL/6 
polypeptide Q60714 UniProt | EBI | MGI Sequence Detail 646 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(21) UniProt(4)
Polymorphisms SNPs within 2kb(156 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020845 AMP-binding, conserved site
InterPro IPR000873 AMP-dependent synthetase/ligase
InterPro IPR025110 Domain of unknown function DUF4009
Protein Ontology PR:000015045 long-chain fatty acid transport protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:21397 Schaffer JE, et al., Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein [see comments]. Cell. 1994 Nov 4;79(3):427-36
(Latest) J:206863 Khalifeh-Soltani A, et al., Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med. 2014 Feb;20(2):175-83
All references(52)
Other
accession IDs
MGD-MRK-19704, MGI:102796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory