Slc27a1 MGI Mouse Gene Detail - MGI:1347098 - solute carrier family 27 (fatty acid transporter), member 1

Symbol

Slc27a1
Name

solute carrier family 27 (fatty acid transporter), member 1
Synonyms

Fatp, FATP1

Feature Type

protein coding gene
IDs

MGI:1347098
NCBI Gene: 26457
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr8:72021526-72039946 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM, cytoband B3.3
Mapping Data

1 experiment

SNPs within 2kb

159 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347098	protein coding gene	Chr8:72021372-72039951 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033755	protein coding gene	Chr8:71981739-71999062 (+)
A/J	MGP_AJ_G0033738	protein coding gene	Chr8:69043939-69061404 (+)
AKR/J	MGP_AKRJ_G0033664	protein coding gene	Chr8:71080114-71096082 (+)
BALB/cJ	MGP_BALBcJ_G0033734	protein coding gene	Chr8:69215681-69233099 (+)
C3H/HeJ	MGP_C3HHeJ_G0033444	protein coding gene	Chr8:71662036-71680670 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034252	protein coding gene	Chr8:74716488-74738410 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031194	protein coding gene	Chr8:63679097-63701190 (+)
CAST/EiJ	MGP_CASTEiJ_G0032769	protein coding gene	Chr8:71124293-71141409 (+)
CBA/J	MGP_CBAJ_G0033422	protein coding gene	Chr8:77369176-77386520 (+)
DBA/2J	MGP_DBA2J_G0033576	protein coding gene	Chr8:68772689-68789905 (+)
FVB/NJ	MGP_FVBNJ_G0033518	protein coding gene	Chr8:67858017-67874459 (+)
LP/J	MGP_LPJ_G0033663	protein coding gene	Chr8:71951410-71970287 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033565	protein coding gene	Chr8:79910841-79930292 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034269	protein coding gene	Chr8:71146470-71164976 (+)
PWK/PhJ	MGP_PWKPhJ_G0032476	protein coding gene	Chr8:68055866-68074181 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032313	protein coding gene	Chr8:70095491-70111742 (+)
WSB/EiJ	MGP_WSBEiJ_G0032885	protein coding gene	Chr8:71492815-71511618 (+)

Human Ortholog

SLC27A1, solute carrier family 27 member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC27A1, solute carrier family 27 member 1
Synonyms

ACSVL5, FATP, FATP1, FATP-1
Links

HGNC:10995

NCBI Gene ID: 376497

neXtProt AC: NX_Q6PCB7

UniProt: Q6PCB7
Chr Location

19p13.11; chr19:17468767-17506168 (+) GRCh38

MGI Vertebrate Homology

Slc27a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC27A1
Gene Tree

Slc27a1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Slc27a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants are protected from fat-induced insulin resistance and intramuscular accumulation of fatty acid metabolites without alterations in whole body adiposity.

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All GO Annotations

80
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1207
Tissues

155
cDNA Data

62
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc27a1a

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All Sequences

103
RefSeq

51
UniProt

6
CCDS

CCDS40386.1

Ensembl

ENSMUSG00000031808 (Evidence)
NCBI Gene

26457

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031808	Ensembl Gene Model \| MGI Sequence Detail	18421	C57BL/6J	± kb
transcript	ENSMUST00000212889	Ensembl \| MGI Sequence Detail	2730	Not Applicable
polypeptide	ENSMUSP00000148768	Ensembl \| MGI Sequence Detail	646	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015045 long-chain fatty acid transport protein 1

(term hierarchy)
EC

6.2.1.-, 6.2.1.15, 6.2.1.3
InterPro Domains

IPR020845 AMP-binding, conserved site

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

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All nucleic 66

Genomic 3

cDNA 62

Primer pair 1

Microarray probesets 3

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MGD-MRK-19704, MGI:102796

Summaries

All 79

Developmental Gene Expression 14

Gene Ontology 25

Phenotypes 16
Earliest

J:21397 Schaffer JE, et al., Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein [see comments]. Cell. 1994 Nov 4;79(3):427-36
Latest

J:344186 Munoz-Gallardo MDM, et al., miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810

TSS for Slc27a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77870	Chr8:72021510-72021575 (+)	17 bp
Tssr77871	Chr8:72021601-72021627 (+)	88 bp
Tssr77872	Chr8:72022301-72022333 (+)	791 bp
Tssr77873	Chr8:72023225-72023245 (+)	1,709 bp
Tssr77874	Chr8:72023261-72023275 (+)	1,742 bp
Tssr77875	Chr8:72023311-72023369 (+)	1,814 bp
Tssr77876	Chr8:72023370-72023467 (+)	1,893 bp
Tssr77877	Chr8:72026638-72026643 (+)	5,115 bp
Tssr2604	Chr8:72028553-72028557 (+)	7,029 bp
Tssr77878	Chr8:72031876-72031881 (+)	10,353 bp
Tssr77879	Chr8:72031907-72031944 (+)	10,400 bp
Tssr77880	Chr8:72031950-72031964 (+)	10,431 bp
Tssr77881	Chr8:72031973-72031991 (+)	10,456 bp
Tssr77882	Chr8:72032057-72032092 (+)	10,549 bp
Tssr77883	Chr8:72033073-72033090 (+)	11,556 bp
Tssr77884	Chr8:72033107-72033125 (+)	11,590 bp
Tssr77885	Chr8:72033127-72033150 (+)	11,613 bp
Tssr77886	Chr8:72033160-72033170 (+)	11,639 bp
Tssr77887	Chr8:72033172-72033209 (+)	11,665 bp
Tssr77888	Chr8:72038574-72038601 (+)	17,062 bp
Tssr77889	Chr8:72038759-72038772 (+)	17,240 bp
Tssr77890	Chr8:72039123-72039170 (+)	17,621 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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