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Slc27a1 Gene Detail
Summary
  • Symbol
    Slc27a1
  • Name
    solute carrier family 27 (fatty acid transporter), member 1
  • Synonyms
    Fatp, FATP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347098
    NCBI Gene: 26457
  • Gene Overview
    MyGene.info: SLC27A1
Location & Maps
more
  • Sequence Map
    Chr8:71568927-71586708 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17782 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC27A1, solute carrier family 27 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC27A1, solute carrier family 27 member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACSVL5, FATP, FATP1, FATP-1
  • Links
    NCBI Gene ID: 376497
    neXtProt AC: NX_Q6PCB7

  • Chr Location
    19p13.11; chr19:17468774-17506168 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    1 involving Slc27a1
  • Incidental Mutations
Homozygous null mutants are protected from fat-induced insulin resistance and intramuscular accumulation of fatty acid metabolites without alterations in whole body adiposity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031808 Ensembl Gene Model | MGI Sequence Detail 17782 C57BL/6J ±  kb
transcript ENSMUST00000034267 Ensembl | MGI Sequence Detail 2795 Not Applicable  
polypeptide ENSMUSP00000034267 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    158 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015045 long-chain fatty acid transport protein 1
  • EC
  • InterPro Domains
    IPR020845 AMP-binding, conserved site
    IPR025110 AMP-binding enzyme C-terminal domain
    IPR000873 AMP-dependent synthetase/ligase
    IPR030308 Fatty acid transport protein 1
Molecular
Reagents
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  • All nucleic 65
    Genomic 3
    cDNA 61
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19704, MGI:102796
References
more
  • Summaries
    All 50
    Developmental Gene Expression 8
    Gene Ontology 16
    Phenotypes 10
  • Earliest
    J:21397 Schaffer JE, et al., Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein [see comments]. Cell. 1994 Nov 4;79(3):427-36
  • Latest
    J:217937 Lin MH, et al., Fatty Acid transport protein 1 can compensate for Fatty Acid transport protein 4 in the developing mouse epidermis. J Invest Dermatol. 2015 Feb;135(2):462-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory