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Slc27a1 Gene Detail
Summary
  • Symbol
    Slc27a1
  • Name
    solute carrier family 27 (fatty acid transporter), member 1
  • Synonyms
    Fatp, FATP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347098
    NCBI Gene: 26457
  • Gene Overview
    MyGene.info: SLC27A1
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71568882-71587302 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM, cytoband B3.3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347098
protein coding gene Chr8:71568873-71587304 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033755
protein coding gene Chr8:71981739-71999062 (+)
A/J MGP_AJ_G0033738
protein coding gene Chr8:69043939-69061404 (+)
AKR/J MGP_AKRJ_G0033664
protein coding gene Chr8:71080114-71096082 (+)
BALB/cJ MGP_BALBcJ_G0033734
protein coding gene Chr8:69215681-69233099 (+)
C3H/HeJ MGP_C3HHeJ_G0033444
protein coding gene Chr8:71662036-71680670 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034252
protein coding gene Chr8:74716488-74738410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031194
protein coding gene Chr8:63679097-63701190 (+)
CAST/EiJ MGP_CASTEiJ_G0032769
protein coding gene Chr8:71124293-71141409 (+)
CBA/J MGP_CBAJ_G0033422
protein coding gene Chr8:77369176-77386520 (+)
DBA/2J MGP_DBA2J_G0033576
protein coding gene Chr8:68772689-68789905 (+)
FVB/NJ MGP_FVBNJ_G0033518
protein coding gene Chr8:67858017-67874459 (+)
LP/J MGP_LPJ_G0033663
protein coding gene Chr8:71951410-71970287 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033565
protein coding gene Chr8:79910841-79930292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034269
protein coding gene Chr8:71146470-71164976 (+)
PWK/PhJ MGP_PWKPhJ_G0032476
protein coding gene Chr8:68055866-68074181 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032313
protein coding gene Chr8:70095491-70111742 (+)
WSB/EiJ MGP_WSBEiJ_G0032885
protein coding gene Chr8:71492815-71511618 (+)



Homology
more
  • Human Ortholog
    SLC27A1, solute carrier family 27 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC27A1, solute carrier family 27 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACSVL5, FATP, FATP1, FATP-1
  • Links
    NCBI Gene ID: 376497
    neXtProt AC: NX_Q6PCB7
    UniProt: Q6PCB7

  • Chr Location
    19p13.11; chr19:17468745-17506169 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are protected from fat-induced insulin resistance and intramuscular accumulation of fatty acid metabolites without alterations in whole body adiposity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031808 Ensembl Gene Model | MGI Sequence Detail 18421 C57BL/6J ±  kb
transcript ENSMUST00000212889 Ensembl | MGI Sequence Detail 2730 Not Applicable  
polypeptide ENSMUSP00000148768 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    Genomic 3
    cDNA 62
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19704, MGI:102796
References
more
  • Summaries
    All 64
    Developmental Gene Expression 9
    Gene Ontology 21
    Phenotypes 10
  • Earliest
    J:21397 Schaffer JE, et al., Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein [see comments]. Cell. 1994 Nov 4;79(3):427-36
  • Latest
    J:245686 Cubizolle A, et al., Fatty acid transport protein 1 regulates retinoid metabolism and photoreceptor development in mouse retina. PLoS One. 2017;12(7):e0180148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory