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Adgre5 Gene Detail
Summary
  • Symbol
    Adgre5
  • Name
    adhesion G protein-coupled receptor E5
  • Synonyms
    Cd97, EGF-TM7 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347095
    NCBI Gene: 26364
  • Gene Overview
    MyGene.info: ADGRE5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:83723251-83741311 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347095
protein coding gene Chr8:83723251-83741326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033840
protein coding gene Chr8:84567954-84587253 (-)
A/J MGP_AJ_G0033823
protein coding gene Chr8:81262015-81281029 (-)
AKR/J MGP_AKRJ_G0033749
protein coding gene Chr8:83658941-83677063 (-)
BALB/cJ MGP_BALBcJ_G0033816
protein coding gene Chr8:81362855-81380964 (-)
C3H/HeJ MGP_C3HHeJ_G0033526
protein coding gene Chr8:84277309-84295402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034336
protein coding gene Chr8:87787049-87805124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031278
protein coding gene Chr8:75047609-75066533 (-)
CAST/EiJ MGP_CASTEiJ_G0032856
protein coding gene Chr8:83686390-83704517 (-)
CBA/J MGP_CBAJ_G0033504
protein coding gene Chr8:90944287-90962380 (-)
DBA/2J MGP_DBA2J_G0033657
protein coding gene Chr8:80901849-80919942 (-)
FVB/NJ MGP_FVBNJ_G0033603
protein coding gene Chr8:79814954-79833819 (-)
LP/J MGP_LPJ_G0033747
protein coding gene Chr8:84669675-84687797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033645
protein coding gene Chr8:93434467-93454158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034353
protein coding gene Chr8:83630068-83649539 (-)
PWK/PhJ MGP_PWKPhJ_G0032560
protein coding gene Chr8:80115750-80134113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032397
protein coding gene Chr8:82430856-82452352 (-)
WSB/EiJ MGP_WSBEiJ_G0032969
protein coding gene Chr8:84038074-84057481 (-)



Homology
more
  • Human Ortholog
    ADGRE5, adhesion G protein-coupled receptor E5
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ADGRE5, adhesion G protein-coupled receptor E5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD97, TM7LN1
  • Links
    NCBI Gene ID: 976
    neXtProt AC: NX_P48960
    UniProt: P48960

  • Chr Location
    19p13.12; chr19:14381144-14408725 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype apart from mild granulocytosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26364 NCBI Gene Model | MGI Sequence Detail 18061 C57BL/6J ±  kb
transcript NM_011925 RefSeq | MGI Sequence Detail 3253 C57BL/6  
polypeptide Q9Z0M6 UniProt | EBI | MGI Sequence Detail 818 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142420
References
more
  • Summaries
    All 73
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 44
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory