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Cd97
Gene Detail
 Symbol
Name
ID
Cd97
CD97 antigen
MGI:1347095
Synonyms EGF-TM7 receptor
Feature Type protein coding gene
Genetic Map
Chromosome 8
40.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:83723251-83741326 bp, - strand
From VEGA annotation of GRCm38

  18076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 4 zebrafish

Protein SuperFamily: EGF-like module-containing mucin-like hormone receptor-like 2 and CD97
Gene Tree: Cd97

Human
homologs
Human Homolog CD97, CD97 molecule
NCBI Gene ID 976
neXtProt AC  NX_P48960
Human Synonyms  TM7LN1
Human Chr (Location)  19p13; chr19:14380591-14408725 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(49) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype apart from mild granulocytosis.
 
Interactions
Cd97 interacts with 82 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, cell surface receptor signaling pathway, ...
Component extracellular vesicular exosome, focal adhesion, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (260)    Tissues (121)    Images (122)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 99
In situ reporter (knock in) 123
RT-PCR 38
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022225 (Evidence)
Ensembl Gene ModelENSMUSG00000002885 (Evidence)
Entrez Gene26364 (Evidence)
UniGene334648
DFCITC1576516, TC1588051, TC1611445, TC1661489
NIA Mouse Gene IndexU030019
Consensus CDS ProjectCCDS22461.1, CCDS52610.1, CCDS52611.1, CCDS52612.1
International Mouse Knockout Project StatusCd97
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022225 VEGA Gene Model | MGI Sequence Detail 18076 C57BL/6J ±  kb
transcript OTTMUST00000052855 VEGA | MGI Sequence Detail 3000 Not Applicable 
polypeptide OTTMUSP00000025113 VEGA | MGI Sequence Detail 818 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(14) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003056 GPCR, family 2, CD97 antigen
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR000203 GPS domain
Protein Ontology PR:000001311 CD97 molecule
References (Earliest) J:57794 Carver EA, et al., Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication. Mamm Genome. 1999 Oct;10(10):1039-40
(Latest) J:194835 Karpus ON, et al., Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55. J Immunol. 2013 Apr 1;190(7):3740-8
All references(41)
Other
accession IDs
MGI:2142420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory