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Adgre5 Gene Detail
Summary
  • Symbol
    Adgre5
  • Name
    adhesion G protein-coupled receptor E5
  • Synonyms
    Cd97, EGF-TM7 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347095
    NCBI Gene: 26364
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84449874-84467812 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347095
 protein coding gene Chr8:84449874-84467955 (-)
129S1/SvImJ ENSMUSG00200023527
 protein coding gene Chr8:78821036-78839155 (-)
A/J ENSMUSG00195015719
 protein coding gene Chr8:79177770-79195864 (-)
AKR/J ENSMUSG00220023121
 protein coding gene Chr8:79218470-79236589 (-)
BALB/cJ ENSMUSG00180017507
 protein coding gene Chr8:79019704-79037825 (-)
C3H/HeJ ENSMUSG00175010320
 protein coding gene Chr8:79108655-79126746 (-)
C57BL/6NJ ENSMUSG00215018654
 protein coding gene Chr8:78744342-78762419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031278
 protein coding gene Chr8:75047609-75066533 (-)
CAST/EiJ ENSTCUG00005031952
 protein coding gene Chr8:78632273-78650402 (-)
CBA/J ENSMUSG00210020184
 protein coding gene Chr8:79100954-79119049 (-)
DBA/2J ENSMUSG00185033653
 protein coding gene Chr8:85209765-85227858 (-)
FVB/NJ ENSMUSG00205036533
 protein coding gene Chr8:78155842-78173917 (-)
JF1/MsJ ENSUMUG00000033007
 protein coding gene Chr8:87500537-87518619 (-)
LP/J ENSMUSG00230025095
 protein coding gene Chr8:88817888-88836007 (-)
NOD/ShiLtJ ENSMUSG00190022644
 protein coding gene Chr8:79167074-79185169 (-)
NZO/HlLtJ ENSMUSG00225038853
 protein coding gene Chr8:92205494-92223569 (-)
PWK/PhJ ENSLUMG00010025801
 protein coding gene Chr8:78858361-78876437 (-)
SPRET/EiJ ENSMSPG00010023339
 protein coding gene Chr8:80768984-80789217 (-)
WSB/EiJ ENSIUOG00005014882
 protein coding gene Chr8:79910284-79928404 (-)



Homology
more
  • Human Ortholog
    ADGRE2, adhesion G protein-coupled receptor E2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRE2, adhesion G protein-coupled receptor E2
  • Synonyms
    CD312, CD97, EMR2, VBU
  • Links
    NCBI Gene ID: 30817
    UniProt: Q9UHX3

  • Chr Location
    19p13.12; chr19:14724171-14778560 (-)  GRCh38
  • Human Ortholog
    ADGRE5, adhesion G protein-coupled receptor E5
  • Synonyms
    CD97, TM7LN1
  • Links
    NCBI Gene ID: 976
    UniProt: P48960

  • Chr Location
    19p13.12; chr19:14380501-14408729 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADGRE2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype apart from mild granulocytosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    120
  • cDNA Data
    94
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26364 NCBI Gene Model | MGI Sequence Detail 17939 C57BL/6J ±  kb
transcript NM_011925 RefSeq | MGI Sequence Detail 3131 ZRU/MplStud  
polypeptide Q9Z0M6 UniProt | EBI | MGI Sequence Detail 818 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142420
References
more
  • Summaries
    All 97
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 58
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:381198 Chang H, et al., The CD97-PPM1G axis dampens antiviral immunity by dephosphorylating IRF7 in type I interferon pathway. PLoS Pathog. 2026 Mar;22(3):e1014032
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory