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Fto Gene Detail
Summary
  • Symbol
    Fto
  • Name
    fat mass and obesity associated
  • Synonyms
    mKIAA1752
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347093
    NCBI Gene: 26383
  • Gene Overview
    MyGene.info: FTO
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:91313525-91668439 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      354915 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.34 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FTO, FTO, alpha-ketoglutarate dependent dioxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FTO, FTO, alpha-ketoglutarate dependent dioxygenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALKBH9, BMIQ14, GDFD
  • Links
    NCBI Gene ID: 79068
    neXtProt AC: NX_Q9C0B1
    UniProt: Q9C0B1

  • Chr Location
    16q12.2; chr16:53703963-54114467 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8053
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FTO
  • Gene Tree
    Fto
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 10 alleles in 9 genetic backgrounds
    13 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025730 VEGA Gene Model | MGI Sequence Detail 354915 C57BL/6J ±  kb
    transcript OTTMUST00000063364 VEGA | MGI Sequence Detail 3564 Not Applicable  
    polypeptide OTTMUSP00000031320 VEGA | MGI Sequence Detail 502 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4241 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
      IPR032868 Alpha-ketoglutarate-dependent dioxygenase FTO
      IPR024367 Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
      IPR024366 Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
      IPR038413 FTO, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 166
      Genomic 1
      cDNA 163
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142818
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 35
    • Earliest
      J:57790 Peters T, et al., Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome. 1999 Oct;10(10):983-6
    • Latest
      J:253321 Tai H, et al., Protein kinase Cbeta activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation. FASEB J. 2017 Oct;31(10):4396-4406

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory