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Fto
Gene Detail
 Symbol
Name
ID
Fto
fat mass and obesity associated
MGI:1347093
Synonyms mKIAA1752
Feature Type protein coding gene
Genetic Map
Chromosome 8
44.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:91313532-91668439 bp, + strand
From VEGA annotation of GRCm38

  354908 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fto

Human
homologs
Human Homolog FTO, fat mass and obesity associated
NCBI Gene ID 79068
neXtProt AC  NX_Q9C0B1
Human Synonyms  ALKBH9
Human Chr (Location)  16q12.2; chr16:53703963-54114467 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FTO
Alleles
and
phenotypes
All alleles(52) : Chemically induced (ENU)(1) Gene trapped(43) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent.
 
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process adipose tissue development, cellular response to DNA damage stimulus, ...
Component nuclear speck, nucleus
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (23)    Images (3)
Theiler Stages: 13, 15, 17, 19, 20, 21, 23, 28
Assay TypeResults
RT-PCR 25
cDNA source data(162)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(166) Genomic(1) cDNA(163) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025730 (Evidence)
Ensembl Gene ModelENSMUSG00000055932 (Evidence)
Entrez Gene26383 (Evidence)
UniGene4375
DFCITC1573448, TC1608713, TC1627276, TC1663518
DoTSDT.101308377, DT.101388238, DT.101738193, DT.484298, DT.492278, DT.94235433
NIA Mouse Gene IndexU009632, U066971
EC1.14.11.-
Consensus CDS ProjectCCDS22521.1
International Mouse Knockout Project StatusFto
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025730 VEGA Gene Model | MGI Sequence Detail 354908 C57BL/6J ±  kb
transcript OTTMUST00000063364 VEGA | MGI Sequence Detail 3557 Not Applicable 
polypeptide OTTMUSP00000031320 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(4265 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4281)
Protein-related
information
ResourceIDDescription
InterPro IPR024367 Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
InterPro IPR024366 Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Protein Ontology PR:000007694 alpha-ketoglutarate-dependent dioxygenase FTO
References (Earliest) J:57790 Peters T, et al., Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome. 1999 Oct;10(10):983-6
(Latest) J:203742 Hess ME, et al., The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci. 2013 Aug;16(8):1042-8
All references(57)
Other
accession IDs
MGI:2142818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory