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Fto
Gene Detail
Symbol

Name
ID
Fto
fat mass and obesity associated
MGI:1347093
Synonyms
mKIAA1752
Feature Type
protein coding gene
Genetic Map
Chromosome 8
44.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:91313532-91668439 bp, + strand
From VEGA annotation of GRCm38

  354908 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FTO
Gene Tree: Fto

Human
homologs
FTO, fat mass and obesity associated
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79068
neXtProt AC: NX_Q9C0B1

Human Synonyms: ALKBH9

Human Chr (Location): 16q12.2; chr16:53703963-54114467 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FTO

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Chemically induced (ENU)(1) Gene trapped(43) Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent.
 
Interactions
Fto interacts with 248 markers (Mir7-1, Mir16-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (23)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 25
cDNA source data(162)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fto ; ZFIN fto    NEW 
Molecular
reagents
All nucleic(166) Genomic(1) cDNA(163) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025730 (Evidence)
Ensembl Gene Model ENSMUSG00000055932 (Evidence)
Entrez Gene 26383 (Evidence)
UniGene 4375
DFCI TC1573448, TC1608713, TC1627276, TC1663518
DoTS DT.101308377, DT.101388238, DT.101738193, DT.484298, DT.492278, DT.94235433
NIA Mouse Gene Index U009632, U066971
EC 1.14.11.-
Consensus CDS Project CCDS22521.1
International Mouse Phenotyping Consortium Status Fto
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025730 VEGA Gene Model | MGI Sequence Detail 354908 C57BL/6J ±  kb
transcript OTTMUST00000063364 VEGA | MGI Sequence Detail 3557 Not Applicable 
polypeptide OTTMUSP00000031320 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(4265 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4281)
Protein-related
information
ResourceIDDescription
InterPro IPR024367 Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
InterPro IPR024366 Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Protein Ontology PR:000007694 alpha-ketoglutarate-dependent dioxygenase FTO
References
(Earliest) J:57790 Peters T, et al., Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome. 1999 Oct;10(10):983-6
(Latest) J:220973 Tung YC, et al., FTO is necessary for the induction of leptin resistance by high-fat feeding. Mol Metab. 2015 Apr;4(4):287-98
All references(62)
Other
accession IDs
MGI:2142818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory