Fto
Gene Detail

Symbol Name ID

Fto fat mass and obesity associated MGI:1347093

Synonyms

mKIAA1752

Feature Type

protein coding gene

Genetic Map

Chromosome 8

44.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:91313532-91668439 bp, + strand From VEGA annotation of GRCm38   354908 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fto

Human homologs

Human Homolog		FTO, fat mass and obesity associated
NCBI Gene ID		79068
neXtProt AC		NX_Q9C0B1
Human Chr (Location)		16q12.2; chr16:53737875-54148379 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FTO

Alleles and phenotypes

All alleles(50) : Targeted(6) Gene trapped(43) Chemically induced(1)
 

Mice homozygous for an ENU-induced or targeted knock-out allele exhibit decreased body weight, adipose tissue, and body fat and increased metabolism, serum lipids, and serum glucagon that may be gender and diet dependent.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	adipose tissue development, DNA dealkylation involved in DNA repair, ...
Component	nucleus
Function	DNA-N1-methyladenine dioxygenase activity, ferrous iron binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (23)    Images (3)
Theiler Stages: 13, 15, 17, 19, 20, 21, 23, 28

Assay Type	Results
RT-PCR	25

cDNA source data(158)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(162) Genomic(1) cDNA(159) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025730 (Evidence)
Ensembl Gene Model	ENSMUSG00000055932 (Evidence)
Entrez Gene	26383 (Evidence)
UniGene	4375
DFCI	TC1573448, TC1608713, TC1627276, TC1663518
DoTS	DT.101308377, DT.101388238, DT.101738193, DT.484298, DT.492278, DT.94235433
NIA Mouse Gene Index	U009632, U066971
EC	1.14.11.-
Consensus CDS Project	CCDS22521.1
International Mouse Knockout Project Status	Fto

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025730	VEGA Gene Model | MGI Sequence Detail	354908	C57BL/6J
transcript	OTTMUST00000063364	VEGA | MGI Sequence Detail	3557	Not Applicable
polypeptide	OTTMUSP00000031320	VEGA | MGI Sequence Detail	502	Not Applicable

All sequences(61) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(2665 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024367	Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
InterPro	IPR024366	Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Protein Ontology	PR:000007694	protein fto

References

(Earliest) J:57790 Peters T, et al., Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome. 1999 Oct;10(10):983-6
(Latest) J:194327 Gulati P, et al., Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62
All references(52)

Other accession IDs

MGI:2142818