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Cetn1 Gene Detail
Summary
  • Symbol
    Cetn1
  • Name
    centrin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347086
    NCBI Gene: 26369
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:9618419-9619469 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.91 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347086
 protein coding gene Chr18:9615524-9619478 (-)
129S1/SvImJ ENSMUSG00200023691
 protein coding gene Chr18:6547688-6551676 (-)
A/J ENSMUSG00195008326
 protein coding gene Chr18:6726580-6730562 (-)
AKR/J ENSMUSG00220018334
 protein coding gene Chr18:6717769-6721745 (-)
BALB/cJ ENSMUSG00180005290
 protein coding gene Chr18:7168049-7172030 (-)
C3H/HeJ ENSMUSG00175007261
 protein coding gene Chr18:6703403-6707388 (-)
C57BL/6NJ ENSMUSG00215008441
 protein coding gene Chr18:6451992-6455947 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021986
 protein coding gene Chr18:6053790-6057652 (-)
CAST/EiJ ENSTCUG00005016859
 protein coding gene Chr18:6595157-6599101 (-)
CBA/J ENSMUSG00210021333
 protein coding gene Chr18:6716319-6720302 (-)
DBA/2J ENSMUSG00185028084
 protein coding gene Chr18:6730305-6734259 (-)
FVB/NJ ENSMUSG00205021651
 protein coding gene Chr18:6511385-6515345 (-)
JF1/MsJ ENSUMUG00000027862
 protein coding gene Chr18:6795282-6799309 (-)
LP/J ENSMUSG00230026255
 protein coding gene Chr18:8792275-8796260 (-)
NOD/ShiLtJ ENSMUSG00190009742
 protein coding gene Chr18:6503120-6507074 (-)
NZO/HlLtJ ENSMUSG00225033117
 protein coding gene Chr18:8713762-8717716 (-)
PWK/PhJ ENSLUMG00010008783
 protein coding gene Chr18:6979910-6983939 (-)
SPRET/EiJ ENSMSPG00010010748
 protein coding gene Chr18:6634441-6635500 (-)
WSB/EiJ ENSIUOG00005025702
 protein coding gene Chr18:6580115-6584056 (-)



Homology
more
  • Human Ortholog
    CETN1, centrin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CETN1, centrin 1
  • Synonyms
    CEN1, CETN
  • Links
    NCBI Gene ID: 1068
    UniProt: Q12798

  • Chr Location
    18p11.32; chr18:580380-582114 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show male infertility associated with oligozoospermia, teratozoospermia, immotile sperm, and altered centriole rearrangement at a late stage of spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    96
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26369 NCBI Gene Model | MGI Sequence Detail 1051 C57BL/6J ±  kb
    transcript NM_007593 RefSeq | MGI Sequence Detail 1051 C57BL/6  
    polypeptide P41209 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 2
      cDNA 96
      Antibodies 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 3
    • Earliest
      J:15453 Ogawa K, et al., cDNA sequence for mouse caltractin. Biochim Biophys Acta. 1993 Oct 19;1216(1):126-8
    • Latest
      J:376526 Sakai T, et al., Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2503931122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory