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Cetn1 Gene Detail
Summary
  • Symbol
    Cetn1
  • Name
    centrin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347086
    NCBI Gene: 26369
  • Gene Overview
    MyGene.info: CETN1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:9618419-9619469 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347086
protein coding gene Chr18:9615524-9619478 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024141
protein coding gene Chr18:6541356-6545199 (-)
A/J MGP_AJ_G0024103
protein coding gene Chr18:6499733-6504782 (-)
AKR/J MGP_AKRJ_G0024070
protein coding gene Chr18:6657765-6663486 (-)
BALB/cJ MGP_BALBcJ_G0024102
protein coding gene Chr18:6477539-6481715 (-)
C3H/HeJ MGP_C3HHeJ_G0023869
protein coding gene Chr18:6545764-6551022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024547
protein coding gene Chr18:6930027-6936781 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021986
protein coding gene Chr18:6053790-6057652 (-)
CAST/EiJ MGP_CASTEiJ_G0023346
protein coding gene Chr18:6516678-6520544 (-)
CBA/J MGP_CBAJ_G0023841
protein coding gene Chr18:6922857-6926726 (-)
DBA/2J MGP_DBA2J_G0023970
protein coding gene Chr18:6353001-6357379 (-)
FVB/NJ MGP_FVBNJ_G0023935
protein coding gene Chr18:6319832-6324774 (-)
LP/J MGP_LPJ_G0024053
protein coding gene Chr18:6617076-6620946 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023964
protein coding gene Chr18:7124313-7129380 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024593
protein coding gene Chr18:6497946-6502978 (-)
PWK/PhJ MGP_PWKPhJ_G0023091
protein coding gene Chr18:6385419-6389638 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022902
protein coding gene Chr18:6802739-6806582 (-)
WSB/EiJ MGP_WSBEiJ_G0023412
protein coding gene Chr18:6481062-6485048 (-)



Homology
more
  • Human Ortholog
    CETN1, centrin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CETN1, centrin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CEN1, CETN
  • Links
    NCBI Gene ID: 1068
    neXtProt AC: NX_Q12798
    UniProt: Q12798

  • Chr Location
    18p11.32; chr18:580343-582020 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show male infertility associated with oligozoospermia, teratozoospermia, immotile sperm, and altered centriole rearrangement at a late stage of spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26369 NCBI Gene Model | MGI Sequence Detail 1051 C57BL/6J ±  kb
    transcript NM_007593 RefSeq | MGI Sequence Detail 1051 C57BL/6  
    polypeptide P41209 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 2
      cDNA 96

      Microarray probesets 6
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 4
    • Earliest
      J:15453 Ogawa K, et al., cDNA sequence for mouse caltractin. Biochim Biophys Acta. 1993 Oct 19;1216(1):126-8
    • Latest
      J:285028 de Bruijn SE, et al., Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa. J Med Genet. 2018 Oct;55(10):705-712

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    03/30/2021
    MGI 6.16
    The Jackson Laboratory