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Fgd2 Gene Detail
Summary
  • Symbol
    Fgd2
  • Name
    FYVE, RhoGEF and PH domain containing 2
  • Synonyms
    Tcd2, Tcd-2, tcs2, tcs-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347084
    NCBI Gene: 26382
  • Gene Overview
    MyGene.info: FGD2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29360904-29379535 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347084
protein coding gene Chr17:29360904-29379660 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023464
protein coding gene Chr17:28889044-28909713 (+)
A/J MGP_AJ_G0023422
protein coding gene Chr17:27911738-27931464 (+)
AKR/J MGP_AKRJ_G0023387
protein coding gene Chr17:28136664-28161123 (+)
BALB/cJ MGP_BALBcJ_G0023427
protein coding gene Chr17:28160722-28179571 (+)
C3H/HeJ MGP_C3HHeJ_G0023188
protein coding gene Chr17:28517956-28536732 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023869
protein coding gene Chr17:30034879-30055967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021344
protein coding gene Chr17:25220700-25240234 (+)
CAST/EiJ MGP_CASTEiJ_G0022689
protein coding gene Chr17:28489996-28509203 (+)
CBA/J MGP_CBAJ_G0023163
protein coding gene Chr17:31165256-31185917 (+)
DBA/2J MGP_DBA2J_G0023293
protein coding gene Chr17:27425316-27444048 (+)
FVB/NJ MGP_FVBNJ_G0023263
protein coding gene Chr17:27259991-27279941 (+)
LP/J MGP_LPJ_G0023371
protein coding gene Chr17:29142323-29163539 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023281
protein coding gene Chr17:30493002-30515075 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023911
protein coding gene Chr17:28599323-28618819 (+)
PWK/PhJ MGP_PWKPhJ_G0022439
protein coding gene Chr17:26261974-26282669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022257
protein coding gene Chr17:26584320-26608665 (+)
WSB/EiJ MGP_WSBEiJ_G0022751
protein coding gene Chr17:28557740-28577727 (+)



Homology
more
  • Human Ortholog
    FGD2, FYVE, RhoGEF and PH domain containing 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FGD2, FYVE, RhoGEF and PH domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZFYVE4
  • Links
    NCBI Gene ID: 221472
    neXtProt AC: NX_Q7Z6J4
    UniProt: Q7Z6J4

  • Chr Location
    6p21.2; chr6:37005647-37029072 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 26382 NCBI Gene Model | MGI Sequence Detail 18632 C57BL/6J ±  kb
transcript NM_001159538 RefSeq | MGI Sequence Detail 2634 C57BL/6  
polypeptide Q8BY35 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14738, MGD-MRK-14743, MGD-MRK-14932, MGD-MRK-14935, MGI:98500
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:7443 Lyon MF, Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984 Jun;37(2):621-8
  • Latest
    J:143609 Huber C, et al., FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem. 2008 Dec 5;283(49):34002-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory