Fgd2
Gene Detail

Symbol Name ID

Fgd2 FYVE, RhoGEF and PH domain containing 2 MGI:1347084

Synonyms

Tcd2, Tcd-2, tcs2, tcs-2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

15.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:29360914-29379660 bp, + strand From VEGA annotation of GRCm38   18747 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd2

Human homologs

Human Homolog		FGD2, FYVE, RhoGEF and PH domain containing 2
NCBI Gene ID		221472
neXtProt AC		NX_Q7Z6J4
Human Synonyms		ZFYVE4
Human Chr (Location)		6p21.2; chr6:36973423-36996845 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	regulation of Rho protein signal transduction
Component	cell projection, cytoplasm, ...
Function	guanyl-nucleotide exchange factor activity, metal ion binding, ...

External Resources: FuncBase

Expression

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000028987 (Evidence)
Ensembl Gene Model	ENSMUSG00000024013 (Evidence)
Entrez Gene	26382 (Evidence)
UniGene	279187
DFCI	TC1580937, TC1595300, TC1728312
DoTS	DT.101377118, DT.91568078, DT.94122654
NIA Mouse Gene Index	U017766
Consensus CDS Project	CCDS37537.1
International Mouse Knockout Project Status	Fgd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028987	VEGA Gene Model | MGI Sequence Detail	18747	C57BL/6J
transcript	OTTMUST00000071875	VEGA | MGI Sequence Detail	2612	Not Applicable
polypeptide	OTTMUSP00000036906	VEGA | MGI Sequence Detail	655	Not Applicable

All sequences(44) RefSeq(4) UniProt(2)

Polymorphisms

PCR(1) : SNPs(155 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR000306	Zinc finger, FYVE-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000007474	FYVE, RhoGEF and PH domain-containing protein 2

References

(Earliest) J:7443 Lyon MF, Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984 Jun;37(2):621-8
(Latest) J:143609 Huber C, et al., FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem. 2008 Dec 5;283(49):34002-12
All references(37)

Other accession IDs

MGD-MRK-14738, MGD-MRK-14743, MGD-MRK-14932, MGD-MRK-14935, MGI:98500