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Fgd2
Gene Detail
 Symbol
Name
ID
Fgd2
FYVE, RhoGEF and PH domain containing 2
MGI:1347084
Synonyms Tcd2, Tcd-2, tcs2, tcs-2
Feature Type protein coding gene
Genetic Map
Chromosome 17
15.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:29360914-29379660 bp, + strand
From VEGA annotation of GRCm38

  18747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd2

Human
homologs
Human Homolog FGD2, FYVE, RhoGEF and PH domain containing 2
NCBI Gene ID 221472
neXtProt AC  NX_Q7Z6J4
Human Synonyms  ZFYVE4
Human Chr (Location)  6p21.2; chr6:37005647-37029069 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process regulation of Rho protein signal transduction
Component cell projection, cytoplasm, ...
Function guanyl-nucleotide exchange factor activity, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000028987 (Evidence)
Ensembl Gene ModelENSMUSG00000024013 (Evidence)
Entrez Gene26382 (Evidence)
UniGene279187
DFCITC1580937, TC1595300, TC1728312
DoTSDT.101377118, DT.91568078, DT.94122654
NIA Mouse Gene IndexU017766
Consensus CDS ProjectCCDS37537.1
International Mouse Knockout Project StatusFgd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028987 VEGA Gene Model | MGI Sequence Detail 18747 C57BL/6J ±  kb
transcript OTTMUST00000071875 VEGA | MGI Sequence Detail 2612 Not Applicable 
polypeptide OTTMUSP00000036906 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(17) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(304 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000007474 FYVE, RhoGEF and PH domain-containing protein 2
References (Earliest) J:7443 Lyon MF, Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984 Jun;37(2):621-8
(Latest) J:143609 Huber C, et al., FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem. 2008 Dec 5;283(49):34002-12
All references(37)
Other
accession IDs
MGD-MRK-14738, MGD-MRK-14743, MGD-MRK-14932, MGD-MRK-14935, MGI:98500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory