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Fgd2
Gene Detail
Symbol

Name
ID
Fgd2
FYVE, RhoGEF and PH domain containing 2
MGI:1347084
Synonyms
Tcd2, Tcd-2, tcs2, tcs-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:29360914-29379660 bp, + strand
From VEGA annotation of GRCm38

  18747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: FGD2
Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd2

Human
homologs
FGD2, FYVE, RhoGEF and PH domain containing 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 221472
neXtProt AC: NX_Q7Z6J4

Human Synonyms: ZFYVE4

Human Chr (Location): 6p21.2; chr6:37005647-37029070 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Fgd2 interacts with 195 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process regulation of Rho protein signal transduction
Component cell projection, cytoplasm, ...
Function guanyl-nucleotide exchange factor activity, metal ion binding, ...
External Resources: FuncBase
Expression
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000028987 (Evidence)
Ensembl Gene Model ENSMUSG00000024013 (Evidence)
Entrez Gene 26382 (Evidence)
UniGene 279187
DFCI TC1595300, TC1580937, TC1728312
DoTS DT.91568078, DT.101377118, DT.94122654
NIA Mouse Gene Index U017766
Consensus CDS Project CCDS37537.1
International Mouse Phenotyping Consortium Status Fgd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028987 VEGA Gene Model | MGI Sequence Detail 18747 C57BL/6J ±  kb
transcript OTTMUST00000071875 VEGA | MGI Sequence Detail 2612 Not Applicable 
polypeptide OTTMUSP00000036906 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(16) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(304 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000007474 FYVE, RhoGEF and PH domain-containing protein 2
References
(Earliest) J:7443 Lyon MF, Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984 Jun;37(2):621-8
(Latest) J:143609 Huber C, et al., FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem. 2008 Dec 5;283(49):34002-12
All references(35)
Other
accession IDs
MGD-MRK-14738, MGD-MRK-14743, MGD-MRK-14932, MGD-MRK-14935, MGI:98500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory