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Grk6
Gene Detail
 Symbol
Name
ID
Grk6
G protein-coupled receptor kinase 6
MGI:1347078
Synonyms Gprk6
Feature Type protein coding gene
Genetic Map
Chromosome 13
30.06 cM, cytoband B1-3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:55445334-55460925 bp, + strand
From Ensembl annotation of GRCm38

  15592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37570  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk6

Human
homologs
Human Homolog GRK6, G protein-coupled receptor kinase 6
NCBI Gene ID 2870
neXtProt AC  NX_P43250
Human Synonyms  GPRK6
Human Chr (Location)  5q35; chr5:177426496-177442849 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(21) Targeted(8)
Genomic Mutations involving Grk6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Grk6 interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process desensitization of G-protein coupled receptor protein signaling pathway, negative regulation of anion channel activity, ...
Component cytosol, membrane, ...
Function ATP binding, G-protein coupled receptor kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (13)    Images (11)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 7
Northern blot 24
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(1) cDNA(79) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000074886 (Evidence)
Entrez Gene26385 (Evidence)
UniGene10193
DFCITC1577088, TC1595106, TC1660589, TC1662208, TC1669501
DoTSDT.101184301, DT.101278800, DT.532992, DT.97414180, DT.99849267
NIA Mouse Gene IndexU014887
EC2.7.11.16
Consensus CDS ProjectCCDS36676.1, CCDS49272.1
International Mouse Knockout Project StatusGrk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074886 Ensembl Gene Model | MGI Sequence Detail 15592 C57BL/6J ±  kb
transcript ENSMUST00000001115 Ensembl | MGI Sequence Detail 2996 Not Applicable 
polypeptide ENSMUSP00000001115 Ensembl | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(18) UniProt(5)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008260 G protein-coupled receptor kinase 6
References (Earliest) J:57781 Moepps B, et al., Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6. Genomics. 1999 Sep 1;60(2):199-209
(Latest) J:202546 Raghuwanshi SK, et al., G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013 May 15;190(10):5329-36
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory