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Grk6 Gene Detail
Summary
  • Symbol
    Grk6
  • Name
    G protein-coupled receptor kinase 6
  • Synonyms
    Gprk6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347078
    NCBI Gene: 26385
  • Gene Overview
    MyGene.info: GRK6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55445072-55460927 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B1-3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347078
protein coding gene Chr13:55445072-55460927 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020597
protein coding gene Chr13:54930483-54946076 (+)
A/J MGP_AJ_G0020551
protein coding gene Chr13:52897016-52914755 (+)
AKR/J MGP_AKRJ_G0020529
protein coding gene Chr13:54462545-54479433 (+)
BALB/cJ MGP_BALBcJ_G0020547
protein coding gene Chr13:53130514-53146633 (+)
C3H/HeJ MGP_C3HHeJ_G0020346
protein coding gene Chr13:54271126-54288860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020981
protein coding gene Chr13:56589487-56605616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018563
protein coding gene Chr13:50838458-50854154 (+)
CAST/EiJ MGP_CASTEiJ_G0019860
protein coding gene Chr13:54373437-54390584 (+)
CBA/J MGP_CBAJ_G0020306
protein coding gene Chr13:58756174-58771981 (+)
DBA/2J MGP_DBA2J_G0020429
protein coding gene Chr13:52451212-52466791 (+)
FVB/NJ MGP_FVBNJ_G0020408
protein coding gene Chr13:51917395-51934242 (+)
LP/J MGP_LPJ_G0020505
protein coding gene Chr13:55186567-55202385 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020437
protein coding gene Chr13:58231839-58248007 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021024
protein coding gene Chr13:54044005-54059605 (+)
PWK/PhJ MGP_PWKPhJ_G0019616
protein coding gene Chr13:52474706-52491130 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019443
protein coding gene Chr13:52969209-52987094 (+)
WSB/EiJ MGP_WSBEiJ_G0019922
protein coding gene Chr13:54398491-54415661 (+)



Homology
more
  • Human Ortholog
    GRK6, G protein-coupled receptor kinase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRK6, G protein-coupled receptor kinase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GPRK6
  • Links
    NCBI Gene ID: 2870
    neXtProt AC: NX_P43250
    UniProt: P43250

  • Chr Location
    5q35.3; chr5:177426496-177442849 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26385 NCBI Gene Model | MGI Sequence Detail 15856 C57BL/6J ±  kb
    transcript NM_001038018 RefSeq | MGI Sequence Detail 3016 C57BL/6  
    polypeptide O70293 UniProt | EBI | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 80
      Primer pair 2
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:263790 Franco A, et al., G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts. J Mol Cell Cardiol. 2018 Jun 30;121:60-68

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory