Grk6
Gene Detail

Symbol Name ID

Grk6 G protein-coupled receptor kinase 6 MGI:1347078

Synonyms

Gprk6

Feature Type

protein coding gene

Genetic Map

Chromosome 13

30.06 cM, cytoband B1-3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:55445334-55460925 bp, + strand From Ensembl annotation of GRCm38   15592 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37570  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk6

Human homologs

Human Homolog		GRK6, G protein-coupled receptor kinase 6
NCBI Gene ID		2870
neXtProt AC		NX_P43250
Human Synonyms		GPRK6
Human Chr (Location)		5q35; chr5:176853687-176869850 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(28) : Targeted(7) Gene trapped(21)
 

Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	desensitization of G-protein coupled receptor protein signaling pathway, negative regulation of anion channel activity, ...
Component	cytosol, membrane, ...
Function	ATP binding, G-protein coupled receptor kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (13)    Images (11)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	7
Northern blot	24

cDNA source data(79)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(84) Genomic(1) cDNA(79) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000074886 (Evidence)
Entrez Gene	26385 (Evidence)
UniGene	10193
DFCI	TC1577088, TC1595106, TC1660589, TC1662208, TC1669501
DoTS	DT.101184301, DT.101278800, DT.532992, DT.97414180, DT.99849267
NIA Mouse Gene Index	U014887
EC	2.7.11.16
Consensus CDS Project	CCDS36676.1, CCDS49272.1
International Mouse Knockout Project Status	Grk6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000074886	Ensembl Gene Model | MGI Sequence Detail	15592	C57BL/6J
transcript	ENSMUST00000001115	Ensembl | MGI Sequence Detail	2996	Not Applicable
polypeptide	ENSMUSP00000001115	Ensembl | MGI Sequence Detail	589	Not Applicable

All sequences(50) RefSeq(6) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000239	GPCR kinase
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008260	G-protein coupled receptor kinase 6

References

(Earliest) J:57781 Moepps B, et al., Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6. Genomics. 1999 Sep 1;60(2):199-209
(Latest) J:189842 Raghuwanshi SK, et al., The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions. J Immunol. 2012 Sep 15;189(6):2824-32
All references(50)