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Grk6 Gene Detail
Summary
  • Symbol
    Grk6
  • Name
    G protein-coupled receptor kinase 6
  • Synonyms
    Gprk6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347078
    NCBI Gene: 26385
  • Gene Overview
    MyGene.info: GRK6
Location & Maps
more
  • Sequence Map
    Chr13:55445334-55460925 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B1-3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GRK6, G protein-coupled receptor kinase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRK6, G protein-coupled receptor kinase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPRK6
  • Links
    NCBI Gene ID: 2870
    neXtProt AC: NX_P43250

  • Chr Location
    5q35.3; chr5:177426496-177442849 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Targeted
    8
  • Genomic Mutations
    2 involving Grk6
  • Incidental Mutations
Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074886 Ensembl Gene Model | MGI Sequence Detail 15592 C57BL/6J ±  kb
transcript ENSMUST00000001115 Ensembl | MGI Sequence Detail 2996 Not Applicable  
polypeptide ENSMUSP00000001115 Ensembl | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    Genomic 1
    cDNA 79
    Primer pair 2
    Other 2

    Microarray probesets 5
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:57781 Moepps B, et al., Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6. Genomics. 1999 Sep 1;60(2):199-209
  • Latest
    J:228381 Ohba Y, et al., GRK6 phosphorylates IkappaBalpha at Ser(32)/Ser(36) and enhances TNF-alpha-induced inflammation. Biochem Biophys Res Commun. 2015 May 29;461(2):307-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory