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Grk6
Gene Detail
Symbol

Name
ID
Grk6
G protein-coupled receptor kinase 6
MGI:1347078
Synonyms
Gprk6
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.06 cM, cytoband B1-3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:55445334-55460925 bp, + strand
From Ensembl annotation of GRCm38

  15592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37570  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRK6
Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk6

Human
homologs
GRK6, G protein-coupled receptor kinase 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2870
neXtProt AC: NX_P43250

Human Synonyms: GPRK6

Human Chr (Location): 5q35; chr5:177426496-177442849 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(21) Targeted(8)
Genomic Mutations involving Grk6 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Grk6 interacts with 223 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (13)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
Northern blot 24
cDNA source data(79)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grk6    NEW 
Molecular
reagents
All nucleic(84) Genomic(1) cDNA(79) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000074886 (Evidence)
Entrez Gene 26385 (Evidence)
UniGene 10193
DFCI TC1595106, TC1577088, TC1669501, TC1660589, TC1662208
DoTS DT.532992, DT.97414180, DT.101278800, DT.101184301, DT.99849267
NIA Mouse Gene Index U014887
EC 2.7.11.16
Consensus CDS Project CCDS36676.1, CCDS49272.1
International Mouse Phenotyping Consortium Status Grk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074886 Ensembl Gene Model | MGI Sequence Detail 15592 C57BL/6J ±  kb
transcript ENSMUST00000001115 Ensembl | MGI Sequence Detail 2996 Not Applicable 
polypeptide ENSMUSP00000001115 Ensembl | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(18) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008260 G protein-coupled receptor kinase 6
References
(Earliest) J:57781 Moepps B, et al., Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6. Genomics. 1999 Sep 1;60(2):199-209
(Latest) J:202546 Raghuwanshi SK, et al., G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013 May 15;190(10):5329-36
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory