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Nubp1 Gene Detail
Summary
  • Symbol
    Nubp1
  • Name
    nucleotide binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347073
    NCBI Gene: 26425
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:10411948-10424428 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 5.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NUBP1, nucleotide binding protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NUBP1, nucleotide binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NBP, NBP1, NBP35
  • Links
    NCBI Gene ID: 4682
    neXtProt AC: NX_P53384
    UniProt: P53384

  • Chr Location
    16p13.13; chr16:10743164-10769351 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation display neonatal lethality, respiratory failure, severe lung hypoplasia, impaired lung development, syndactyly and oligodactyly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025747 VEGA Gene Model | MGI Sequence Detail 12481 C57BL/6J ±  kb
    transcript OTTMUST00000063425 VEGA | MGI Sequence Detail 2121 Not Applicable  
    polypeptide OTTMUSP00000031348 VEGA | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      135 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011476 cytosolic Fe-S cluster assembly factor NUBP1
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR028601 Cytosolic Fe-S cluster assembly factor NUBP1/Nbp35
      IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
      IPR000808 Mrp, conserved site
      IPR019591 Mrp/NBP35 ATP-binding protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
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    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 9
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:57779 Nakashima H, et al., Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. Genomics. 1999 Sep 1;60(2):152-60
    • Latest
      J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory