About   Help   FAQ
Nubp1
Gene Detail
Symbol

Name
ID
Nubp1
nucleotide binding protein 1
MGI:1347073
Feature Type
protein coding gene
Genetic Map
Chromosome 16
5.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:10411948-10424428 bp, + strand
From VEGA annotation of GRCm38

  12481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1857  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nucleotide-binding protein, Mrp/NBP35 type
Gene Tree: Nubp1

Human
homologs
Human Homolog NUBP1, nucleotide binding protein 1
NCBI Gene ID 4682
neXtProt AC  NX_P53384
Human Synonyms  NBP, NBP1, NBP35
Human Chr (Location)  16p13.13; chr16:10743786-10769351 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU induced mutation display neonatal lethality, respiratory failure, severe lung hypoplasia, impaired lung development, syndactyly and oligodactyly.
 
Interactions
Nubp1 interacts with 138 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell growth, cellular iron ion homeostasis, ...
Component cytoplasm, cytosol, ...
Function 4 iron, 4 sulfur cluster binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000025747 (Evidence)
Ensembl Gene ModelENSMUSG00000022503 (Evidence)
Entrez Gene26425 (Evidence)
NIA Mouse Gene IndexU043493
Consensus CDS ProjectCCDS27948.1
International Mouse Knockout Project StatusNubp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025747 VEGA Gene Model | MGI Sequence Detail 12481 C57BL/6J ±  kb
transcript OTTMUST00000063425 VEGA | MGI Sequence Detail 2121 Not Applicable 
polypeptide OTTMUSP00000031348 VEGA | MGI Sequence Detail 320 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(3) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR025723 Anion-transporting ATPase-like domain
InterPro IPR019591 ATPase-like, ParA/MinD
InterPro IPR000808 Mrp, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011476 cytosolic Fe-S cluster assembly factor NUBP1
References
(Earliest) J:57779 Nakashima H, et al., Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. Genomics. 1999 Sep 1;60(2):152-60
(Latest) J:191793 Schnatwinkel C, et al., Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012;7(9):e44871
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory