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Med21
Gene Detail
 Symbol
Name
ID
Med21
mediator complex subunit 21
MGI:1347064
Synonyms 0610007L03Rik, D6Ertd782e, Srb7, Surb7
Feature Type protein coding gene
Genetic Map
Chromosome 6
77.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:146642547-146650602 bp, + strand
From VEGA annotation of GRCm38

  8056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Med21

Human
homologs
Human Homolog MED21, mediator complex subunit 21
NCBI Gene ID 9412
neXtProt AC  NX_Q13503
Human Synonyms  hSrb7, SRB7, SURB7
Human Chr (Location)  12p11.23; chr12:27022522-27030673 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a targeted null mutation die at the blastocyst stage.
 
Interactions
Med21 interacts with 61 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process blastocyst development, positive regulation of transcription from RNA polymerase II promoter, ...
Component mediator complex, nucleus
Function protein binding, transcription coactivator activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (200)    Tissues (106)    Images (1)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 200
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(61) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025704 (Evidence)
Ensembl Gene ModelENSMUSG00000030291 (Evidence)
Entrez Gene108098 (Evidence)
UniGene26212
DFCITC1578686, TC1593258
DoTSDT.533195, DT.55121975, DT.91339929
NIA Mouse Gene IndexU007575
Consensus CDS ProjectCCDS20700.1
International Mouse Knockout Project StatusMed21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025704 VEGA Gene Model | MGI Sequence Detail 8056 C57BL/6J ±  kb
transcript OTTMUST00000063306 VEGA | MGI Sequence Detail 814 Not Applicable 
polypeptide OTTMUSP00000031286 VEGA | MGI Sequence Detail 144 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021384 Mediator complex, subunit Med21
Protein Ontology PR:000010293 mediator of RNA polymerase II transcription subunit 21
References (Earliest) J:57760 Tudor M, et al., Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev. 1999 Sep 15;13(18):2365-8
(Latest) J:164442 Kagey MH, et al., Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010 Sep 23;467(7314):430-5
All references(42)
Other
accession IDs
MGI:1289181, MGI:1913295, MGI:2141415, MGI:2141792

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory