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Dapp1 Gene Detail
Summary
  • Symbol
    Dapp1
  • Name
    dual adaptor for phosphotyrosine and 3-phosphoinositides 1
  • Synonyms
    Bam32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347063
    NCBI Gene: 26377
  • Gene Overview
    MyGene.info: DAPP1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137931007-137981545 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 63.98 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347063
protein coding gene Chr3:137931007-137981549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027921
protein coding gene Chr3:140961187-141018485 (-)
A/J MGP_AJ_G0027878
protein coding gene Chr3:135978134-136028664 (-)
AKR/J MGP_AKRJ_G0027844
protein coding gene Chr3:139594313-139646708 (-)
BALB/cJ MGP_BALBcJ_G0027890
protein coding gene Chr3:135786845-135839235 (-)
C3H/HeJ MGP_C3HHeJ_G0027620
protein coding gene Chr3:139923972-139976650 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028334
protein coding gene Chr3:145826031-145879219 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025672
protein coding gene Chr3:131080982-131131332 (-)
CAST/EiJ MGP_CASTEiJ_G0027076
protein coding gene Chr3:139683127-139739085 (-)
CBA/J MGP_CBAJ_G0027597
protein coding gene Chr3:150783514-150838466 (-)
DBA/2J MGP_DBA2J_G0027736
protein coding gene Chr3:135101077-135151501 (-)
FVB/NJ MGP_FVBNJ_G0027703
protein coding gene Chr3:132560925-132612411 (-)
LP/J MGP_LPJ_G0027846
protein coding gene Chr3:142368268-142422423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027735
protein coding gene Chr3:158888689-158944219 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028392
protein coding gene Chr3:139137087-139190607 (-)
PWK/PhJ MGP_PWKPhJ_G0026800
protein coding gene Chr3:134852389-134905096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026627
protein coding gene Chr3:137223700-137275583 (-)
WSB/EiJ MGP_WSBEiJ_G0027155
protein coding gene Chr3:139953410-140008096 (-)



Homology
more
  • Human Ortholog
    DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAM32
  • Links
    NCBI Gene ID: 27071
    neXtProt AC: NX_Q9UN19
    UniProt: Q9UN19

  • Chr Location
    4q23; chr4:99816824-99872290 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32138
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DAPP1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this gene invokes immune defects stemming from impaired B cell receptor crosslinking.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028159 Ensembl Gene Model | MGI Sequence Detail 50539 C57BL/6J ±  kb
    transcript ENSMUST00000029806 Ensembl | MGI Sequence Detail 3083 Not Applicable  
    polypeptide ENSMUSP00000029806 Ensembl | MGI Sequence Detail 280 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:57026 Dowler S, et al., DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J. 1999 Aug 15;342(Pt 1):7-12
    • Latest
      J:191280 Rouquette-Jazdanian AK, et al., LAT-independent Erk activation via Bam32-PLC-gamma1-Pak1 complexes: GTPase-independent Pak1 activation. Mol Cell. 2012 Oct 26;48(2):298-312

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory