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Dapp1 Gene Detail
Summary
  • Symbol
    Dapp1
  • Name
    dual adaptor for phosphotyrosine and 3-phosphoinositides 1
  • Synonyms
    Bam32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347063
    NCBI Gene: 26377
  • Gene Overview
    MyGene.info: DAPP1
Location & Maps
more
  • Sequence Map
    Chr3:137931007-137981545 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50539 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 63.98 cM, cytoband H2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAM32
  • Links
    NCBI Gene ID: 27071
    neXtProt AC: NX_Q9UN19

  • Chr Location
    4q23; chr4:99816824-99872249 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32138
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DAPP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Dapp1
  • Incidental Mutations
Inactivation of this gene invokes immune defects stemming from impaired B cell receptor crosslinking.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022230 VEGA Gene Model | MGI Sequence Detail 50539 C57BL/6J ±  kb
transcript OTTMUST00000052872 VEGA | MGI Sequence Detail 3083 Not Applicable  
polypeptide OTTMUSP00000025121 VEGA | MGI Sequence Detail 280 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    338 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006280 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  • InterPro Domains
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR000980 SH2 domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 15
  • Earliest
    J:57026 Dowler S, et al., DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J. 1999 Aug 15;342(Pt 1):7-12
  • Latest
    J:191280 Rouquette-Jazdanian AK, et al., LAT-independent Erk activation via Bam32-PLC-gamma1-Pak1 complexes: GTPase-independent Pak1 activation. Mol Cell. 2012 Oct 26;48(2):298-312

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory