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Dapp1
Gene Detail
 Symbol
Name
ID
Dapp1
dual adaptor for phosphotyrosine and 3-phosphoinositides 1
MGI:1347063
Synonyms Bam32
Feature Type protein coding gene
Genetic Map
Chromosome 3
63.98 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:137931007-137981545 bp, - strand
From VEGA annotation of GRCm38

  50539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dapp1

Human
homologs
Human Homolog DAPP1, dual adaptor of phosphotyrosine and 3-phosphoinositides
NCBI Gene ID 27071
neXtProt AC  NX_Q9UN19
Human Synonyms  BAM32
Human Chr (Location)  4q25-q27; chr4:99816824-99870190 (+)  GRCh38
Alleles
and
phenotypes
All alleles(28) : Gene trapped(25) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene invokes immune defects stemming from impaired B cell receptor crosslinking.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component cytoplasm, membrane, ...
Function phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (4)    Images (18)
Theiler Stages: 23
Assay TypeResults
RNA in situ 29
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022230 (Evidence)
Ensembl Gene ModelENSMUSG00000028159 (Evidence)
Entrez Gene26377 (Evidence)
DFCITC1583461, TC1589367, TC1609300, TC1646846, TC1710153
DoTSDT.40136325, DT.40145200, DT.487982, DT.91586771, DT.97406687, DT.97406689
NIA Mouse Gene IndexU024692
Consensus CDS ProjectCCDS17864.1
International Mouse Knockout Project StatusDapp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022230 VEGA Gene Model | MGI Sequence Detail 50539 C57BL/6J ±  kb
transcript OTTMUST00000052872 VEGA | MGI Sequence Detail 3083 Not Applicable 
polypeptide OTTMUSP00000025121 VEGA | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(341 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001720 PI3 kinase, P85 regulatory subunit
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000006280 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
References (Earliest) J:57026 Dowler S, et al., DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J. 1999 Aug 15;342(Pt 1):7-12
(Latest) J:191280 Rouquette-Jazdanian AK, et al., LAT-independent Erk activation via Bam32-PLC-gamma1-Pak1 complexes: GTPase-independent Pak1 activation. Mol Cell. 2012 Oct 26;48(2):298-312
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory