Psma4 Gene Detail

Summary

• Symbol
  Psma4
• Name
  proteasome (prosome, macropain) subunit, alpha type 4
• Synonyms
  C9

• Feature Type
  protein coding gene
• IDs
  MGI:1347060
  NCBI Gene: 26441
• Gene Overview
  MyGene.info: PSMA4
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr9:54950816-54958032 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 29.84 cM, cytoband C
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  107 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347060	protein coding gene	Chr9:54950790-54958032 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0034834	protein coding gene	Chr9:54019573-54026807 (+)
A/J	MGP_AJ_G0034815	protein coding gene	Chr9:52289908-52297148 (+)
AKR/J	MGP_AKRJ_G0034744	protein coding gene	Chr9:53481090-53488330 (+)
BALB/cJ	MGP_BALBcJ_G0034807	protein coding gene	Chr9:52069456-52077227 (+)
C3H/HeJ	MGP_C3HHeJ_G0034517	protein coding gene	Chr9:53947371-53954611 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035326	protein coding gene	Chr9:55523243-55530483 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032238	protein coding gene	Chr9:51705499-51712536 (+)
CAST/EiJ	MGP_CASTEiJ_G0033839	protein coding gene	Chr9:53964457-53973704 (+)
CBA/J	MGP_CBAJ_G0034488	protein coding gene	Chr9:57459580-57473396 (+)
DBA/2J	MGP_DBA2J_G0034647	protein coding gene	Chr9:52184061-52191295 (+)
FVB/NJ	MGP_FVBNJ_G0034589	protein coding gene	Chr9:51387085-51394310 (+)
LP/J	MGP_LPJ_G0034730	protein coding gene	Chr9:54330910-54338271 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034632	protein coding gene	Chr9:58982294-58989703 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035348	protein coding gene	Chr9:53503333-53510573 (+)
PWK/PhJ	MGP_PWKPhJ_G0033543	protein coding gene	Chr9:52163127-52169293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033378	protein coding gene	Chr9:53759958-53766886 (+)
WSB/EiJ	MGP_WSBEiJ_G0033951	protein coding gene	Chr9:53462755-53471286 (+)

Homology

• Human Ortholog
  PSMA4, proteasome subunit alpha 4

• Vertebrate Orthologs
  9

• Human Ortholog
  PSMA4, proteasome subunit alpha 4
  Orthology source: HomoloGene, HGNC
• Synonyms
  HC9, HsT17706, PSC9
• Links
  HGNC:9533

  NCBI Gene ID: 5685

  neXtProt AC: NX_P25789

  UniProt: P25789

  
  
• Chr Location
  15q25.1; chr15:78540405-78549220 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 2083
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: PSMA4
• Gene Tree
  Psma4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  8
• Gene trapped
  5
• Targeted
  3
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  4 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  30
• GO References
  8

• External Resources
  FuncBase

Expression

• cDNA Data
  177
• Literature Summary
  2

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase psma4
  ZFIN psma4

Interactions

• Psma4 interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  49
• RefSeq
  4
• UniProt
  5
• CCDS
  CCDS40643.1
• UniGene
  30270

• Ensembl
  ENSMUSG00000032301 (Evidence)
• NCBI Gene
  26441

Representative Sequences			Length	Strain/Species
genomic	26441	NCBI Gene Model | MGI Sequence Detail	7217	C57BL/6J
transcript	NM_011966	RefSeq | MGI Sequence Detail	1096	C57BL/6
polypeptide	Q9R1P0	UniProt | EBI | MGI Sequence Detail	261	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000013363 proteasome subunit alpha type-4
  (term hierarchy)
• PDB
  3UNB, 3UNE, 3UNF, 3UNH
• EC
  3.4.25.1
• InterPro Domains
  IPR029055 Nucleophile aminohydrolases, N-terminal
  IPR000426 Proteasome alpha-subunit, N-terminal domain
  IPR023332 Proteasome alpha-type subunit
  IPR016050 Proteasome beta-type subunit, conserved site
  IPR034647 Proteasome subunit alpha4
  IPR001353 Proteasome, subunit alpha/beta

Molecular
Reagents

• All nucleic 177

  cDNA 177

  
  

  Microarray probesets 3

References

• Summaries
  All 33

  Developmental Gene Expression 2

  Gene Ontology 8

  Phenotypes 4
• Earliest
  J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
• Latest
  J:228828 Hamazaki J, et al., Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet. 2015 Jul;11(7):e1005401

TSS for Psma4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85192	Chr9:54950782-54950797 (+)	-26 bp
Tssr85193	Chr9:54950808-54950820 (+)	-2 bp
Tssr85194	Chr9:54950838-54950852 (+)	29 bp
Tssr85195	Chr9:54951104-54951126 (+)	299 bp