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Esrrg Gene Detail
Summary
  • Symbol
    Esrrg
  • Name
    estrogen-related receptor gamma
  • Synonyms
    ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347056
    NCBI Gene: 26381
Location & Maps
more
  • Sequence Map
    Chr1:187608791-188214885 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      606095 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 91.83 cM, cytoband H5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERR3, ERRgamma, NR3B3
  • Links
    NCBI Gene ID: 2104
    neXtProt AC: NX_P62508

  • Chr Location
    1q41; chr1:216503246-217137755 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    5
  • Incidental Mutations
    Mutagenetix , APF
Nullizygous mutations lead to postnatal lethality. Homozygotes for a null allele show reduced birth weight, fasting hyperlactatemia, altered electrocardiograms and mitochondrial function, and agenesis of the renal papilla. Surviving homozygotes for a different null allele exhibit hearing loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    448
  • Tissues
    285
  • cDNA Data
    15
  • Literature Summary
    24
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022373 VEGA Gene Model | MGI Sequence Detail 606095 C57BL/6J ±  kb
transcript OTTMUST00000053412 VEGA | MGI Sequence Detail 5293 Not Applicable  
polypeptide OTTMUSP00000025396 VEGA | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3599 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007210 estrogen-related receptor gamma
  • PDB
    1S9P, 1S9Q
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR024178 Oestrogen receptor/oestrogen-related receptor
    IPR027289 Oestrogen-related receptor
    IPR003078 Retinoic acid receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 18
    cDNA 15
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 68
    Developmental Gene Expression 24
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
  • Latest
    J:224699 Kida YS, et al., ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell. 2015 May 7;16(5):547-55
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory