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Esrrg
Gene Detail
 Symbol
Name
ID
Esrrg
estrogen-related receptor gamma
MGI:1347056
Synonyms ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3
Feature Type protein coding gene
Genetic Map
Chromosome 1
91.83 cM, cytoband H5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:187608791-188214885 bp, + strand
From VEGA annotation of GRCm38

  606095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esrrg

Human
homologs
Human Homolog ESRRG, estrogen-related receptor gamma
NCBI Gene ID 2104
neXtProt AC  NX_P62508
Human Synonyms  ERR3, ERRgamma, NR3B3
Human Chr (Location)  1q41; chr1:216503246-217137755 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in complete postnatal lethality. Homozygotes for a knock-out allele exhibit reduced birth weight, absent gastric milk, fasting hyperlactatemia, abnormal electrocardiograms, altered mitochondrial function, and agenesis of the renal papilla.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process intracellular receptor signaling pathway, multicellular organismal development, ...
Component nucleus
Function calmodulin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (452)    Tissues (278)    Images (84)
Theiler Stages: 2, 3, 4, 5, 10, 13, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 257
In situ reporter (knock in) 108
Northern blot 32
RT-PCR 54
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(15) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022373 (Evidence)
Ensembl Gene ModelENSMUSG00000026610 (Evidence)
Entrez Gene26381 (Evidence)
DFCITC1586905, TC1602934, TC1614177, TC1626949
DoTSDT.484431, DT.101284942, DT.91331645, DT.94136655
NIA Mouse Gene IndexU069310
PDB1S9P, 1S9Q
Consensus CDS ProjectCCDS15606.1, CCDS56666.1
International Mouse Knockout Project StatusEsrrg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022373 VEGA Gene Model | MGI Sequence Detail 606095 C57BL/6J ±  kb
transcript OTTMUST00000053412 VEGA | MGI Sequence Detail 5293 Not Applicable 
polypeptide OTTMUSP00000025396 VEGA | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(22) UniProt(3)
Polymorphisms SNPs within 2kb(3642 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR024178 Oestrogen receptor/oestrogen-related receptor
InterPro IPR027289 Oestrogen-related receptor
InterPro IPR003078 Retinoic acid receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000007210 estrogen-related receptor gamma
References (Earliest) J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
(Latest) J:201439 Gan Z, et al., Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013 Jun 3;123(6):2564-75
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory