Esrrg
Gene Detail

Symbol Name ID

Esrrg estrogen-related receptor gamma MGI:1347056

Synonyms

ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3

Feature Type

protein coding gene

Genetic Map

Chromosome 1

91.83 cM, cytoband H5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:187608791-188214885 bp, + strand From VEGA annotation of GRCm38   606095 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55581  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esrrg

Human homologs

Human Homolog		ESRRG, estrogen-related receptor gamma
NCBI Gene ID		2104
neXtProt AC		NX_P62508
Human Synonyms		ERR3, ERRgamma, NR3B3
Human Chr (Location)		1q41; chr1:216503246-217137755 (-)  GRCh38

Alleles and phenotypes

All alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene results in complete postnatal lethality. Homozygotes for a knock-out allele exhibit reduced birth weight, absent gastric milk, fasting hyperlactatemia, abnormal electrocardiograms, altered mitochondrial function, and agenesis of the renal papilla.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	intracellular receptor signaling pathway, multicellular organismal development, ...
Component	nucleus
Function	calmodulin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)

Data Summary: Results (452)    Tissues (278)    Images (84)
Theiler Stages: 2, 3, 4, 5, 10, 13, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	257
In situ reporter (knock in)	108
Northern blot	32
RT-PCR	54

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(15) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022373 (Evidence)
Ensembl Gene Model	ENSMUSG00000026610 (Evidence)
Entrez Gene	26381 (Evidence)
DFCI	TC1586905, TC1602934, TC1614177, TC1626949
DoTS	DT.484431, DT.101284942, DT.91331645, DT.94136655
NIA Mouse Gene Index	U069310
PDB	1S9P, 1S9Q
Consensus CDS Project	CCDS15606.1, CCDS56666.1
International Mouse Knockout Project Status	Esrrg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022373	VEGA Gene Model | MGI Sequence Detail	606095	C57BL/6J
transcript	OTTMUST00000053412	VEGA | MGI Sequence Detail	5293	Not Applicable
polypeptide	OTTMUSP00000025396	VEGA | MGI Sequence Detail	458	Not Applicable

All sequences(66) RefSeq(22) UniProt(3)

Polymorphisms

SNPs within 2kb(3642 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR024178	Oestrogen receptor/oestrogen-related receptor
InterPro	IPR027289	Oestrogen-related receptor
InterPro	IPR003078	Retinoic acid receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000007210	estrogen-related receptor gamma

References

(Earliest) J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
(Latest) J:201439 Gan Z, et al., Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013 Jun 3;123(6):2564-75
All references(58)