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Esrrg Gene Detail
Summary
  • Symbol
    Esrrg
  • Name
    estrogen-related receptor gamma
  • Synonyms
    ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347056
    NCBI Gene: 26381
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:187608791-188214885 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      606095 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 91.83 cM, cytoband H5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ESRRG, estrogen related receptor gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERR3, ERRg, ERRgamma, ERR-gamma, NR3B3
  • Links
    NCBI Gene ID: 2104
    neXtProt AC: NX_P62508
    UniProt: P62508

  • Chr Location
    1q41; chr1:216503246-217137757 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations lead to postnatal lethality. Homozygotes for a null allele show reduced birth weight, fasting hyperlactatemia, altered electrocardiograms and mitochondrial function, and agenesis of the renal papilla. Surviving homozygotes for a different null allele exhibit hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    458
  • Tissues
    293
  • cDNA Data
    16
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022373 VEGA Gene Model | MGI Sequence Detail 606095 C57BL/6J ±  kb
    transcript OTTMUST00000053412 VEGA | MGI Sequence Detail 5293 Not Applicable  
    polypeptide OTTMUSP00000025396 VEGA | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3599 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 28
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
    • Latest
      J:262497 Zhao J, et al., Genomic integration of ERRgamma-HNF1beta regulates renal bioenergetics and prevents chronic kidney disease. Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4910-E4919
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/18/2018
    MGI 6.12     		The Jackson Laboratory