Esrrg MGI Mouse Gene Detail - MGI:1347056 - estrogen-related receptor gamma

Esrrg Gene Detail

Symbol

Esrrg
Name

estrogen-related receptor gamma
Synonyms

ERR3, Errg, estrogen-related receptor 3, mKIAA0832, NR3B3

Feature Type

protein coding gene
IDs

MGI:1347056
NCBI Gene: 26381
Alliance

gene page

Sequence Map

Chr1:187608791-188214885 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

606095 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 91.83 cM, cytoband H5
Mapping Data

3 experiments

Human Ortholog

ESRRG, estrogen related receptor gamma

Vertebrate Orthologs

9

Human Ortholog

ESRRG, estrogen related receptor gamma
Orthology source: HomoloGene, HGNC
Synonyms

ERR3, ERRg, ERRgamma, ERR-gamma, NR3B3
Links

HGNC:3474

NCBI Gene ID: 2104

neXtProt AC: NX_P62508

UniProt: P62508
Chr Location

1q41; chr1:216503246-217137757 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55581
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ESRRG
Protein SuperFamily

ER-like_NR
Gene Tree

Esrrg

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Phenotype Summary

23 phenotypes from 3 alleles in 5 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Nullizygous mutations lead to postnatal lethality. Homozygotes for a null allele show reduced birth weight, fasting hyperlactatemia, altered electrocardiograms and mitochondrial function, and agenesis of the renal papilla. Surviving homozygotes for a different null allele exhibit hearing loss.

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All GO Annotations

24
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

451
Tissues

289
cDNA Data

15
Literature Summary

27

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ESRRG

Xenbase esrrg

ZFIN esrrga, esrrgb

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Esrrg interacts with 495 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

63
RefSeq

28
UniProt

3
CCDS

CCDS15606.1, CCDS56666.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022373	VEGA Gene Model \| MGI Sequence Detail	606095	C57BL/6J	± kb
transcript	OTTMUST00000053412	VEGA \| MGI Sequence Detail	5293	Not Applicable
polypeptide	OTTMUSP00000025396	VEGA \| MGI Sequence Detail	458	Not Applicable

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SNPs within 2kb

3599 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000007210 estrogen-related receptor gamma

(term hierarchy)
PDB

1S9P, 1S9Q
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR024178 Oestrogen receptor/oestrogen-related receptor

IPR027289 Oestrogen-related receptor

IPR003078 Retinoic acid receptor

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 18

cDNA 15

Primer pair 3

Microarray probesets 3

Summaries

All 87

Developmental Gene Expression 27

Gene Ontology 8

Phenotypes 16
Earliest

J:56623 Hong H, et al., Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem. 1999 Aug 6;274(32):22618-26
Latest

J:255229 Son YO, et al., Estrogen-related receptor gamma causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. Nat Commun. 2017 Dec 15;8(1):2133

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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