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Git2 Gene Detail
Summary
  • Symbol
    Git2
  • Name
    G protein-coupled receptor kinase-interactor 2
  • Synonyms
    1500036H07Rik, 5830420E16Rik, 9630056M03Rik, ARF GTPase activating protein 2, B230104M05Rik, Cat-2, Cool associated tyrosine phosphorylated-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347053
    NCBI Gene: 26431
  • Gene Overview
    MyGene.info: GIT2
Location & Maps
more
  • Sequence Map
    Chr5:114727407-114775517 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48111 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GIT2, GIT ArfGAP 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GIT2, GIT ArfGAP 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAT2, CAT-2, PKL
  • Links
    NCBI Gene ID: 9815
    neXtProt AC: NX_Q14161

  • Chr Location
    12q24.11; chr12:109929802-109996389 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41336
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GIT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Git2
  • Incidental Mutations
Mice homozygous for a null allele show frequent splenomegaly, extramedullary hematopoiesis, impaired neutrophil chemotaxis, misoriented hyperproduction of superoxide anions and increased susceptibility to fungal infection. Homozygotes for a gene trap allele have reduced marginal zone B cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014548 VEGA Gene Model | MGI Sequence Detail 48111 C57BL/6J ±  kb
transcript OTTMUST00000034589 VEGA | MGI Sequence Detail 2984 Not Applicable  
polypeptide OTTMUSP00000015483 VEGA | MGI Sequence Detail 759 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    124 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    cDNA 77

    Microarray probesets 5
Other
Accession IDs
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MGI:1919676, MGI:1923277, MGI:1925227, MGI:2443204
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:56615 Bagrodia S, et al., A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem. 1999 Aug 6;274(32):22393-400
  • Latest
    J:228729 Montesinos MS, et al., Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron. 2015 Dec 2;88(5):918-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory