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Git2
Gene Detail
Symbol

Name
ID
Git2
G protein-coupled receptor kinase-interactor 2
MGI:1347053
Synonyms
1500036H07Rik, 5830420E16Rik, 9630056M03Rik, ARF GTPase activating protein 2, B230104M05Rik, Cat-2, Cool associated tyrosine phosphorylated-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:114727407-114775517 bp, - strand
From VEGA annotation of GRCm38

  48111 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Git2

Human
homologs
Human Homolog GIT2, G protein-coupled receptor kinase interacting ArfGAP 2
NCBI Gene ID 9815
neXtProt AC  NX_Q14161
Human Synonyms  CAT2, CAT-2
Human Chr (Location)  12q24.1; chr12:109929802-109996389 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show frequent splenomegaly, extramedullary hematopoiesis, impaired neutrophil chemotaxis, misoriented hyperproduction of superoxide anions and increased susceptibility to fungal infection. Homozygotes for a gene trap allele have reduced marginal zone B cell numbers.
 
Interactions
Git2 interacts with 278 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process behavioral response to pain, phosphorylation, ...
Component focal adhesion, nucleoplasm
Function ARF GTPase activator activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) cDNA(77)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000014548 (Evidence)
Ensembl Gene ModelENSMUSG00000041890 (Evidence)
Entrez Gene26431 (Evidence)
UniGene195632
DFCITC1598435, TC1600654, TC1603544, TC1605815
DoTSDT.101236315, DT.101292820, DT.491304, DT.94205970, DT.99744166
NIA Mouse Gene IndexU026606, U342165
Consensus CDS ProjectCCDS19570.2, CCDS39223.1
International Mouse Knockout Project StatusGit2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014548 VEGA Gene Model | MGI Sequence Detail 48111 C57BL/6J ±  kb
transcript OTTMUST00000034589 VEGA | MGI Sequence Detail 2984 Not Applicable 
polypeptide OTTMUSP00000015483 VEGA | MGI Sequence Detail 759 Not Applicable 

For the selected sequences
All sequences(128) RefSeq(24) UniProt(23)
Polymorphisms
SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001164 Arf GTPase activating protein
InterPro IPR022018 G protein-coupled receptor kinase-interacting protein 1 C term
InterPro IPR013724 Spa2 homology (SHD) of GIT
Protein Ontology PR:000007990 ARF GTPase-activating protein GIT2
References
(Earliest) J:56615 Bagrodia S, et al., A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem. 1999 Aug 6;274(32):22393-400
(Latest) J:211642 Wei J, et al., The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8883-8
All references(47)
Other
accession IDs
MGI:1919676, MGI:1923277, MGI:1925227, MGI:2443204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory