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Git2 Gene Detail
Summary
  • Symbol
    Git2
  • Name
    GIT ArfGAP 2
  • Synonyms
    1500036H07Rik, 5830420E16Rik, 9630056M03Rik, ARF GTPase activating protein 2, B230104M05Rik, Cat-2, Cool associated tyrosine phosphorylated-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347053
    NCBI Gene: 26431
  • Gene Overview
    MyGene.info: GIT2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114727408-114773522 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347053
protein coding gene Chr5:114727407-114775517 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029944
protein coding gene Chr5:117498675-117550544 (-)
A/J MGP_AJ_G0029909
protein coding gene Chr5:112870215-112918292 (-)
AKR/J MGP_AKRJ_G0029847
protein coding gene Chr5:116449514-116499063 (-)
BALB/cJ MGP_BALBcJ_G0029920
protein coding gene Chr5:114233899-114287092 (-)
C3H/HeJ MGP_C3HHeJ_G0029640
protein coding gene Chr5:116960432-117013142 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030374
protein coding gene Chr5:122028387-122083366 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027602
protein coding gene Chr5:107689218-107736720 (-)
CAST/EiJ MGP_CASTEiJ_G0029048
protein coding gene Chr5:115893251-115942594 (-)
CBA/J MGP_CBAJ_G0029607
protein coding gene Chr5:126692558-126743345 (-)
DBA/2J MGP_DBA2J_G0029757
protein coding gene Chr5:112935456-112983807 (-)
FVB/NJ MGP_FVBNJ_G0029714
protein coding gene Chr5:111749340-111800071 (-)
LP/J MGP_LPJ_G0029846
protein coding gene Chr5:118066797-118125219 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029745
protein coding gene Chr5:131074446-131124239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030415
protein coding gene Chr5:115922945-115974283 (-)
PWK/PhJ MGP_PWKPhJ_G0028762
protein coding gene Chr5:111594130-111643695 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028600
protein coding gene Chr5:113473494-113522114 (-)
WSB/EiJ MGP_WSBEiJ_G0029124
protein coding gene Chr5:116512331-116561483 (-)



Homology
more
  • Human Ortholog
    GIT2, GIT ArfGAP 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GIT2, GIT ArfGAP 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAT2, CAT-2, PKL
  • Links
    NCBI Gene ID: 9815
    neXtProt AC: NX_Q14161
    UniProt: Q14161

  • Chr Location
    12q24.11; chr12:109929792-109996389 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41336
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GIT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show frequent splenomegaly, extramedullary hematopoiesis, impaired neutrophil chemotaxis, misoriented hyperproduction of superoxide anions and increased susceptibility to fungal infection. Homozygotes for a gene trap allele have reduced marginal zone B cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26431 NCBI Gene Model | MGI Sequence Detail 46115 C57BL/6J ±  kb
    transcript NM_001347400 RefSeq | MGI Sequence Detail 5178 C57BL/6  
    polypeptide Q9JLQ2 UniProt | EBI | MGI Sequence Detail 708 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR038508 ArfGAP domain superfamily
      IPR037278 ARFGAP/RecO-like zinc finger
      IPR001164 Arf GTPase activating protein
      IPR032352 Arf GTPase-activating protein GIT1/2, coiled-coil domain
      IPR022018 ARF GTPase-activating protein GIT1, C-terminal
      IPR013724 GIT, Spa2 homology (SHD) domain
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919676, MGI:1923277, MGI:1925227, MGI:2443204
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:255354 Siddiqui S, et al., Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Aging (Albany NY). 2017 Mar 4;9(3):706-740

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory