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Clcn6 Gene Detail
Summary
  • Symbol
    Clcn6
  • Name
    chloride channel, voltage-sensitive 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347049
    NCBI Gene: 26372
  • Gene Overview
    MyGene.info: CLCN6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148004259-148038821 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.67 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    373 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347049
protein coding gene Chr4:148004259-148038871 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029114
protein coding gene Chr4:151692711-151727147 (-)
A/J MGP_AJ_G0029079
protein coding gene Chr4:145420947-145456519 (-)
AKR/J MGP_AKRJ_G0029027
protein coding gene Chr4:149381089-149420831 (-)
BALB/cJ MGP_BALBcJ_G0029095
protein coding gene Chr4:145934284-145968648 (-)
C3H/HeJ MGP_C3HHeJ_G0028816
protein coding gene Chr4:149933900-149969425 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029544
protein coding gene Chr4:157221338-157256366 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026790
protein coding gene Chr4:137845053-137878867 (-)
CAST/EiJ MGP_CASTEiJ_G0028229
protein coding gene Chr4:147123616-147161711 (-)
CBA/J MGP_CBAJ_G0028778
protein coding gene Chr4:161731095-161770222 (-)
DBA/2J MGP_DBA2J_G0028926
protein coding gene Chr4:145526856-145563134 (-)
FVB/NJ MGP_FVBNJ_G0028891
protein coding gene Chr4:144610701-144650279 (-)
LP/J MGP_LPJ_G0029017
protein coding gene Chr4:151637680-151675985 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028918
protein coding gene Chr4:165095665-165146932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029576
protein coding gene Chr4:149860266-149896155 (-)
PWK/PhJ MGP_PWKPhJ_G0027949
protein coding gene Chr4:141508757-141547001 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027783
protein coding gene Chr4:144121281-144156514 (-)
WSB/EiJ MGP_WSBEiJ_G0028309
protein coding gene Chr4:150010730-150051630 (-)



Homology
more
  • Human Ortholog
    CLCN6, chloride voltage-gated channel 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLCN6, chloride voltage-gated channel 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLC-6
  • Links
    NCBI Gene ID: 1185
    neXtProt AC: NX_P51797
    UniProt: P51797

  • Chr Location
    1p36.22; chr1:11806096-11843144 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 985
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLCN6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Clcn6 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired nociception, mild behavioral abnormalities, and a progressive neuropathy of the central and peripheral nervous systems with features of neuronal ceroid lipofuscinosis (a lysosomal storage disease).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029016 Ensembl Gene Model | MGI Sequence Detail 34563 C57BL/6J ±  kb
transcript ENSMUST00000137724 Ensembl | MGI Sequence Detail 5198 Not Applicable  
polypeptide ENSMUSP00000121751 Ensembl | MGI Sequence Detail 873 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 53
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140385
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:57786 Kornak U, et al., Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1). Biochim Biophys Acta. 1999 Oct 6;1447(1):100-6
  • Latest
    J:232973 Hirst CS, et al., Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory