Orc4 MGI Mouse Gene Detail - MGI:1347043 - origin recognition complex, subunit 4

Symbol

Orc4
Name

origin recognition complex, subunit 4
Synonyms

mMmORC4, Orc4, Orc4l, Orc4P

Feature Type

protein coding gene
IDs

MGI:1347043
NCBI Gene: 26428
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:48792836-48840287 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 28.42 cM
Mapping Data

2 experiments

SNPs within 2kb

1083 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347043	protein coding gene	Chr2:48792836-48840289 (-)
129S1/SvImJ	ENSMUSG00200010075	protein coding gene	Chr2:45756394-45803213 (-)
A/J	ENSMUSG00195009823	protein coding gene	Chr2:45908957-45957184 (-)
AKR/J	ENSMUSG00220019806	protein coding gene	Chr2:46040945-46088792 (-)
BALB/cJ	ENSMUSG00180020752	protein coding gene	Chr2:45902453-45950038 (-)
C3H/HeJ	ENSMUSG00175013801	protein coding gene	Chr2:45933150-45981052 (-)
C57BL/6NJ	ENSMUSG00215008477	protein coding gene	Chr2:45948060-45995708 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023543	protein coding gene	Chr2:44292069-44342143 (-)
CAST/EiJ	ENSTCUG00005001370	protein coding gene	Chr2:45509197-45556372 (-)
CBA/J	ENSMUSG00210000877	protein coding gene	Chr2:45946693-45994789 (-)
DBA/2J	ENSMUSG00185002507	protein coding gene	Chr2:45806851-45854946 (-)
FVB/NJ	ENSMUSG00205001712	protein coding gene	Chr2:45580901-45630564 (-)
JF1/MsJ	ENSUMUG00000000516	protein coding gene	Chr2:45626335-45673424 (-)
LP/J	ENSMUSG00230000721	protein coding gene	Chr2:47731515-47779738 (-)
NOD/ShiLtJ	ENSMUSG00190001558	protein coding gene	Chr2:45862801-45910065 (-)
NZO/HlLtJ	ENSMUSG00225000436	protein coding gene	Chr2:55438215-55485990 (-)
PWK/PhJ	ENSLUMG00010004170	protein coding gene	Chr2:45792657-45839739 (-)
SPRET/EiJ	ENSMSPG00010010330	protein coding gene	Chr2:46742582-46794616 (-)
WSB/EiJ	ENSIUOG00005001187	protein coding gene	Chr2:45887974-45935108 (-)

Human Ortholog

ORC4, origin recognition complex subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ORC4, origin recognition complex subunit 4
Synonyms

ORC4L, ORC4P
Links

HGNC:8490

NCBI Gene ID: 5000

UniProt: O43929
Chr Location

2q23.1; chr2:147930396-148021784 (-) GRCh38

MGI Vertebrate Homology

Orc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ORC4
Protein SuperFamily

ORC4
Gene Tree

Orc4

Diseases

1 with human ORC4 associations

				Human Disease	Mouse Models
				Meier-Gorlin syndrome 2 IDs Meier-Gorlin syndrome 2 DOID:0080513 OMIM:613800

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

28
Targeted

4
Genomic Mutations

1 involving Orc4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in oocytes exhibit female infertility due to failure of polar body extrusion, impaired DNA synthesis, and arrested female meiosis.

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All GO Annotations

36
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

602
Tissues

3
cDNA Data

22
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase orc4

ZFIN orc4

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All Sequences

107
RefSeq

31
UniProt

8
CCDS

CCDS16022.1, CCDS50582.1

Ensembl

ENSMUSG00000026761 (Evidence)
NCBI Gene

26428

			Length	Strain/Species	Flank
genomic	26428	NCBI Gene Model \| MGI Sequence Detail	47452	C57BL/6J	± kb
transcript	NM_001355296	RefSeq \| MGI Sequence Detail	4064	C57BL/6
polypeptide	O88708	UniProt \| EBI \| MGI Sequence Detail	433	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012033 origin recognition complex subunit 4

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR011646 KAP family P-loop domain

IPR041664 Orc1-like, AAA ATPase domain

IPR016527 Origin recognition complex subunit 4

IPR032705 Origin recognition complex subunit 4, C-terminal

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 6

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 13
Earliest

J:43876 Tugal T, et al., The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J Biol Chem. 1998 Dec 4;273(49):32421-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Orc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24006	Chr2:48839276-48839287 (-)	1,005 bp
Tssr24005	Chr2:48839218-48839268 (-)	1,044 bp
Tssr24004	Chr2:48836327-48836337 (-)	3,955 bp
Tssr24003	Chr2:48825270-48825281 (-)	15,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29