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Orc4 Gene Detail
Summary
  • Symbol
    Orc4
  • Name
    origin recognition complex, subunit 4
  • Synonyms
    mMmORC4, Orc4, Orc4l, Orc4P
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347043
    NCBI Gene: 26428
  • Gene Overview
    MyGene.info: ORC4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:48902824-48950277 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 28.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347043
protein coding gene Chr2:48902754-48950277 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025720
protein coding gene Chr2:48044717-48093321 (-)
A/J MGP_AJ_G0025696
protein coding gene Chr2:46225630-46274224 (-)
AKR/J MGP_AKRJ_G0025666
protein coding gene Chr2:47566214-47617355 (-)
BALB/cJ MGP_BALBcJ_G0025691
protein coding gene Chr2:46344163-46395210 (-)
C3H/HeJ MGP_C3HHeJ_G0025452
protein coding gene Chr2:47539580-47587807 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026137
protein coding gene Chr2:49529007-49579429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023543
protein coding gene Chr2:44292069-44342143 (-)
CAST/EiJ MGP_CASTEiJ_G0024917
protein coding gene Chr2:47585867-47636007 (-)
CBA/J MGP_CBAJ_G0025432
protein coding gene Chr2:51388430-51437596 (-)
DBA/2J MGP_DBA2J_G0025563
protein coding gene Chr2:45857685-45906560 (-)
FVB/NJ MGP_FVBNJ_G0025525
protein coding gene Chr2:45580120-45629423 (-)
LP/J MGP_LPJ_G0025651
protein coding gene Chr2:47963585-48016105 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025556
protein coding gene Chr2:52349970-52403233 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026195
protein coding gene Chr2:47463697-47514000 (-)
PWK/PhJ MGP_PWKPhJ_G0024658
protein coding gene Chr2:45735428-45783759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024463
protein coding gene Chr2:47616124-47662880 (-)
WSB/EiJ MGP_WSBEiJ_G0024984
protein coding gene Chr2:47700473-47748566 (-)



Homology
more
  • Human Ortholog
    ORC4, origin recognition complex subunit 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ORC4, origin recognition complex subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ORC4L, ORC4P
  • Links
    NCBI Gene ID: 5000
    neXtProt AC: NX_O43929
    UniProt: O43929

  • Chr Location
    2q23.1; chr2:147930397-148021604 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ORC4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026761 Ensembl Gene Model | MGI Sequence Detail 47454 C57BL/6J ±  kb
transcript ENSMUST00000028098 Ensembl | MGI Sequence Detail 4066 Not Applicable  
polypeptide ENSMUSP00000028098 Ensembl | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:43876 Tugal T, et al., The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J Biol Chem. 1998 Dec 4;273(49):32421-9
  • Latest
    J:212073 Camarena V, et al., Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome. EMBO Mol Med. 2014;6(8):1003-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory