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Orc4
Gene Detail
 Symbol
Name
ID
Orc4
origin recognition complex, subunit 4
MGI:1347043
Synonyms mMmORC4, Orc4, Orc4l, Orc4P
Feature Type protein coding gene
Genetic Map
Chromosome 2
28.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:48902824-48950277 bp, - strand
From VEGA annotation of GRCm38

  47454 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: origin recognition complex, subunit 4
Gene Tree: Orc4

Human
homologs
Human Homolog ORC4, origin recognition complex, subunit 4
NCBI Gene ID 5000
neXtProt AC  NX_O43929
Human Synonyms  ORC4L, ORC4P
Human Chr (Location)  2q22-q23; chr2:147930397-148021604 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ORC4
Alleles
and
phenotypes
All alleles(31) : Targeted(2) Gene trapped(29)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process DNA replication, DNA replication initiation
Component nuclear origin of replication recognition complex, nucleus, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)    Images (2)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 2
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000012397 (Evidence)
Ensembl Gene ModelENSMUSG00000026761 (Evidence)
Entrez Gene26428 (Evidence)
NIA Mouse Gene IndexU022598
Consensus CDS ProjectCCDS16022.1, CCDS50582.1
International Mouse Knockout Project StatusOrc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012397 VEGA Gene Model | MGI Sequence Detail 47454 C57BL/6J ±  kb
transcript OTTMUST00000029500 VEGA | MGI Sequence Detail 4066 Not Applicable 
polypeptide OTTMUSP00000013281 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(17) UniProt(7)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR016527 Origin recognition complex, subunit 4
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000012033 origin recognition complex subunit 4
References (Earliest) J:43876 Tugal T, et al., The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J Biol Chem. 1998 Dec 4;273(49):32421-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory