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Avpr1b
Gene Detail
Symbol

Name
ID
Avpr1b
arginine vasopressin receptor 1B
MGI:1347010
Synonyms
AVPR3, V1bR, V1BR, V3/V1b, V3/V1b pituitary vasopressin receptor, VPR3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.09 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:131599239-131612000 bp, + strand
From VEGA annotation of GRCm38

  12762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22678  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: AVPR1B
Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Avpr1b

Human
homologs
AVPR1B, arginine vasopressin receptor 1B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 553
neXtProt AC: NX_P47901

Human Synonyms: AVPR3

Human Chr (Location): 1q32; chr1:206109849-206117048 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice for one allele display dysregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. Homozygous null mice for other alleles display decreased aggression or an increased propensity for seizures.
 
Interactions
Avpr1b interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (135)    Tissues (75)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
In situ reporter (knock in) 56
RT-PCR 38
cDNA source data(4)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000020888 (Evidence)
Ensembl Gene Model ENSMUSG00000026432 (Evidence)
Entrez Gene 26361 (Evidence)
UniGene 89986
DFCI TC1589895
DoTS DT.91367635
NIA Mouse Gene Index U000781
Consensus CDS Project CCDS35703.1
International Mouse Phenotyping Consortium Status Avpr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020888 VEGA Gene Model | MGI Sequence Detail 12762 C57BL/6J ±  kb
transcript OTTMUST00000049390 VEGA | MGI Sequence Detail 4023 Not Applicable 
polypeptide OTTMUSP00000022873 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(151 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015076 Domain of unknown function DUF1856
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001817 Vasopressin receptor
InterPro IPR000628 Vasopressin V1B receptor
Protein Ontology PR:000001682 vasopressin V1b receptor
References
(Earliest) J:55963 Ventura MA, et al., Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor. J Mol Endocrinol. 1999 Jun;22(3):251-60
(Latest) J:201122 Yamaguchi Y, et al., Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag. Science. 2013 Oct 4;342(6154):85-90
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory