Avpr1b
Gene Detail

Symbol Name ID

Avpr1b arginine vasopressin receptor 1B MGI:1347010

Synonyms

AVPR3, V1bR, V1BR, V3/V1b, V3/V1b pituitary vasopressin receptor, VPR3

Feature Type

protein coding gene

Genetic Map

Chromosome 1

57.09 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:131599239-131612000 bp, + strand From VEGA annotation of GRCm38   12762 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Avpr1b ± 2 cM)

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Avpr1b

Human ortholog

AVPR1B arginine vasopressin receptor 1B NCBI Gene ID 553
Human Synonyms: AVPR3
Human Chr1:206224283-206231482 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice for one allele display dysregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. Homozygous null mice for other alleles display decreased aggression or an increased propensity for seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, elevation of cytosolic calcium ion concentration, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, peptide hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (135)    Tissues (75)    Images (24)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41
In situ reporter (knock in)	56
RT-PCR	38

cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000020888 (Evidence)
Ensembl Gene Model	ENSMUSG00000026432 (Evidence)
Entrez Gene	26361 (Evidence)
UniGene	89986
DFCI	TC1589895
DoTS	DT.91367635
NIA Mouse Gene Index	U000781
Consensus CDS Project	CCDS35703.1
International Mouse Knockout Project Status	Avpr1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020888	VEGA Gene Model | MGI Sequence Detail	12762	C57BL/6J
transcript	OTTMUST00000049390	VEGA | MGI Sequence Detail	4023	Not Applicable
polypeptide	OTTMUSP00000022873	VEGA | MGI Sequence Detail	421	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015076	Domain of unknown function DUF1856
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001817	Vasopressin receptor
InterPro	IPR000628	Vasopressin V1B receptor
Protein Ontology	PR:000001682	vasopressin V1b receptor

References

(Earliest) J:55963 Ventura MA, et al., Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor. J Mol Endocrinol. 1999 Jun;22(3):251-60
(Latest) J:188254 Budry L, et al., The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
All references(52)