About   Help   FAQ
Avpr1b Gene Detail
Summary
  • Symbol
    Avpr1b
  • Name
    arginine vasopressin receptor 1B
  • Synonyms
    AVPR3, V1bR, V1BR, V3/V1b, V3/V1b pituitary vasopressin receptor, VPR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347010
    NCBI Gene: 26361
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:131599239-131612000 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.09 cM, cytoband E4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AVPR1B, arginine vasopressin receptor 1B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AVPR1B, arginine vasopressin receptor 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AVPR3, V1bR
  • Links
    NCBI Gene ID: 553
    neXtProt AC: NX_P47901
    UniProt: P47901

  • Chr Location
    1q32.1; chr1:206109849-206117048 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice for one allele display dysregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. Homozygous null mice for other alleles display decreased aggression or an increased propensity for seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020888 VEGA Gene Model | MGI Sequence Detail 12762 C57BL/6J ±  kb
    transcript OTTMUST00000049390 VEGA | MGI Sequence Detail 4023 Not Applicable  
    polypeptide OTTMUSP00000022873 VEGA | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      151 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 33
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264677 Koshimizu TA, et al., Complex formation between the vasopressin 1b receptor, beta-arrestin-2, and the mu-opioid receptor underlies morphine tolerance. Nat Neurosci. 2018 Jun;21(6):820-833

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory