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Avpr1b
Gene Detail
 Symbol
Name
ID
Avpr1b
arginine vasopressin receptor 1B
MGI:1347010
Synonyms AVPR3, V1bR, V1BR, V3/V1b, V3/V1b pituitary vasopressin receptor, VPR3
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.09 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:131599239-131612000 bp, + strand
From VEGA annotation of GRCm38

  12762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22678  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Avpr1b

Human
homologs
Human Homolog AVPR1B, arginine vasopressin receptor 1B
NCBI Gene ID 553
neXtProt AC  NX_P47901
Human Synonyms  AVPR3
Human Chr (Location)  1q32; chr1:206109849-206117048 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice for one allele display dysregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. Homozygous null mice for other alleles display decreased aggression or an increased propensity for seizures.
 
Interactions
Avpr1b interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process G-protein coupled receptor signaling pathway, regulation of systemic arterial blood pressure by vasopressin, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, peptide hormone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (135)    Tissues (75)    Images (24)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
In situ reporter (knock in) 56
RT-PCR 38
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020888 (Evidence)
Ensembl Gene ModelENSMUSG00000026432 (Evidence)
Entrez Gene26361 (Evidence)
UniGene89986
DFCITC1589895
DoTSDT.91367635
NIA Mouse Gene IndexU000781
Consensus CDS ProjectCCDS35703.1
International Mouse Knockout Project StatusAvpr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020888 VEGA Gene Model | MGI Sequence Detail 12762 C57BL/6J ±  kb
transcript OTTMUST00000049390 VEGA | MGI Sequence Detail 4023 Not Applicable 
polypeptide OTTMUSP00000022873 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(151 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015076 Domain of unknown function DUF1856
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001817 Vasopressin receptor
InterPro IPR000628 Vasopressin V1B receptor
Protein Ontology PR:000001682 vasopressin V1b receptor
References (Earliest) J:55963 Ventura MA, et al., Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor. J Mol Endocrinol. 1999 Jun;22(3):251-60
(Latest) J:201122 Yamaguchi Y, et al., Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag. Science. 2013 Oct 4;342(6154):85-90
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory