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Plod3 Gene Detail
Summary
  • Symbol
    Plod3
  • Name
    procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
  • Synonyms
    LH3, lysyl hydroxylase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347008
    NCBI Gene: 26433
  • Gene Overview
    MyGene.info: PLOD3
Location & Maps
more
  • Sequence Map
    Chr5:136987019-136996648 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.09 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PLOD3, procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLOD3, procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
    Orthology source: HomoloGene
  • Synonyms
    LH3
  • Links
    NCBI Gene ID: 8985
    neXtProt AC: NX_O60568

  • Chr Location
    7q22; chr7:101205977-101217730 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PLOD3 associations

Human Disease Mouse Models
       Bone Fragility with Contractures, Arterial Rupture, and Deafness   OMIM: 612394
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    3
  • Targeted
    7
  • Incidental Mutations
Homozygous null mice display embryonic lethality, reduced embryonic growth, fragility, and fragmented basement membranes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023396 VEGA Gene Model | MGI Sequence Detail 9630 C57BL/6J ±  kb
transcript OTTMUST00000056808 VEGA | MGI Sequence Detail 3280 Not Applicable  
polypeptide OTTMUSP00000027349 VEGA | MGI Sequence Detail 741 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012878 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
  • EC
  • InterPro Domains
    IPR029044 Nucleotide-diphospho-sugar transferases
    IPR005123 Oxoglutarate/iron-dependent dioxygenase
    IPR001006 Procollagen-lysine 5-dioxygenase
    IPR006620 Prolyl 4-hydroxylase, alpha subunit
Molecular
Reagents
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  • All nucleic 111
    cDNA 111

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140859
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:56595 Ruotsalainen H, et al., Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse. Matrix Biol. 1999 Jun;18(3):325-9
  • Latest
    J:225284 Risteli M, et al., Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. PLoS One. 2014;9(11):e113498

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory