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Plod3
Gene Detail
Symbol

Name
ID
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
MGI:1347008
Synonyms
LH3, lysyl hydroxylase 3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:136987019-136996648 bp, + strand
From VEGA annotation of GRCm38

  9630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: procollagen-lysine 5-dioxygenase
Gene Tree: Plod3

Human
homologs
Human Homolog PLOD3, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
NCBI Gene ID 8985
neXtProt AC  NX_O60568
Human Synonyms  LH3
Human Chr (Location)  7q22; chr7:101205977-101217730 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLOD3
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, reduced embryonic growth, fragility, and fragmented basement membranes.
 
Interactions
Plod3 interacts with 69 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process basement membrane assembly, collagen fibril organization, ...
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function dioxygenase activity, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (149)    Tissues (100)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 149
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) cDNA(111)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023396 (Evidence)
Ensembl Gene ModelENSMUSG00000004846 (Evidence)
Entrez Gene26433 (Evidence)
UniGene251003
DFCITC1572559, TC1596635, TC1745732, TC1767057
NIA Mouse Gene IndexU006314
EC1.14.11.4
Consensus CDS ProjectCCDS19759.1
International Mouse Knockout Project StatusPlod3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023396 VEGA Gene Model | MGI Sequence Detail 9630 C57BL/6J ±  kb
transcript OTTMUST00000056808 VEGA | MGI Sequence Detail 3280 Not Applicable 
polypeptide OTTMUSP00000027349 VEGA | MGI Sequence Detail 741 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR001006 Procollagen-lysine 5-dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
Protein Ontology PR:000012878 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
References
(Earliest) J:56595 Ruotsalainen H, et al., Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse. Matrix Biol. 1999 Jun;18(3):325-9
(Latest) J:195451 Ruotsalainen H, et al., The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin. PLoS One. 2012;7(11):e50045
All references(43)
Other
accession IDs
MGI:2140859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory