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Plod2 Gene Detail
Summary
  • Symbol
    Plod2
  • Name
    procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
  • Synonyms
    D530025C14Rik, LH2, lysyl hydroxylase 2, Plod-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347007
    NCBI Gene: 26432
Location & Maps
more
  • Sequence Map
    Chr9:92542223-92608428 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66206 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 48.40 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PLOD2, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLOD2, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRKS2, LH2, TLH
  • Links
    NCBI Gene ID: 5352
    neXtProt AC: NX_O00469

  • Chr Location
    3q24; chr3:146069436-146161495 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PLOD2 associations

Human Disease Mouse Models
       Bruck Syndrome 2; BRKS2   OMIM: 609220
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Genomic Mutations
    1 involving Plod2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031153 VEGA Gene Model | MGI Sequence Detail 66206 C57BL/6J ±  kb
transcript OTTMUST00000077171 VEGA | MGI Sequence Detail 3663 Not Applicable  
polypeptide OTTMUSP00000040752 VEGA | MGI Sequence Detail 758 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    900 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    cDNA 80
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1925825
References
more
  • Summaries
    All 39
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:56595 Ruotsalainen H, et al., Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse. Matrix Biol. 1999 Jun;18(3):325-9
  • Latest
    J:214961 Milgrom-Hoffman M, et al., Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory