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Psma6
Gene Detail
Symbol

Name
ID
Psma6
proteasome (prosome, macropain) subunit, alpha type 6
MGI:1347006
Feature Type
protein coding gene
Genetic Map
Chromosome 12
23.94 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:55384222-55418454 bp, + strand
From VEGA annotation of GRCm38

  34233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSMA6
Gene Tree: Psma6

Human
homologs
PSMA6, proteasome (prosome, macropain) subunit, alpha type, 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5687
neXtProt AC: NX_P60900

Human Synonyms: IOTA, p27K, PROS27

Human Chr (Location): 14q13; chr14:35278558-35317479 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PSMA6

Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(55) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Psma6 interacts with 190 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(240)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psma6 ; ZFIN psma6a, psma6b    NEW 
Molecular
reagents
All nucleic(240) cDNA(240)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034926 (Evidence)
Ensembl Gene Model ENSMUSG00000021024 (Evidence)
Entrez Gene 26443 (Evidence)
UniGene 30210
DFCI TC1573083, TC1640008, TC1703727
DoTS DT.99863779, DT.94242526, DT.94242524, DT.537106, DT.110947990, DT.101252851
NIA Mouse Gene Index U013964
EC 3.4.25.1
PDB 3UNE, 3UNB, 3UNF, 3UNH
Consensus CDS Project CCDS25917.1
International Mouse Phenotyping Consortium Status Psma6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034926 VEGA Gene Model | MGI Sequence Detail 34233 C57BL/6J ±  kb
transcript OTTMUST00000088808 VEGA | MGI Sequence Detail 1042 Not Applicable 
polypeptide OTTMUSP00000048451 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000426 Proteasome, alpha-subunit, N-terminal domain
InterPro IPR023332 Proteasome A-type subunit
InterPro IPR001353 Proteasome, subunit alpha/beta
Protein Ontology PR:000013365 proteasome subunit alpha type-6
References
(Earliest) J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
(Latest) J:196249 Lukic Z, et al., TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011;8:93
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory