Psma6
Gene Detail

Symbol Name ID

Psma6 proteasome (prosome, macropain) subunit, alpha type 6 MGI:1347006

Feature Type

protein coding gene

Genetic Map

Chromosome 12

23.94 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:55384222-55418454 bp, + strand From VEGA annotation of GRCm38   34233 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Psma6

Human homologs

Human Homolog		PSMA6, proteasome (prosome, macropain) subunit, alpha type, 6
NCBI Gene ID		5687
neXtProt AC		NX_P60900
Human Synonyms		IOTA, p27K, PROS27
Human Chr (Location)		14q13; chr14:35761574-35786680 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PSMA6

Alleles and phenotypes

All alleles(58) : Targeted(3) Gene trapped(55)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	positive regulation of NF-kappaB transcription factor activity, proteolysis, ...
Component	cytoplasm, mitochondrion, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	29

cDNA source data(240)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(240) cDNA(240)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034926 (Evidence)
Ensembl Gene Model	ENSMUSG00000021024 (Evidence)
Entrez Gene	26443 (Evidence)
UniGene	30210
DFCI	TC1573083, TC1640008, TC1703727
DoTS	DT.101252851, DT.110947990, DT.537106, DT.94242524, DT.94242526, DT.99863779
NIA Mouse Gene Index	U013964
EC	3.4.25.1
PDB	3UNB, 3UNE, 3UNF, 3UNH
Consensus CDS Project	CCDS25917.1
International Mouse Knockout Project Status	Psma6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034926	VEGA Gene Model | MGI Sequence Detail	34233	C57BL/6J
transcript	OTTMUST00000088808	VEGA | MGI Sequence Detail	1042	Not Applicable
polypeptide	OTTMUSP00000048451	VEGA | MGI Sequence Detail	246	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000426	Proteasome, alpha-subunit, N-terminal domain
InterPro	IPR023332	Proteasome A-type subunit
InterPro	IPR001353	Proteasome, subunit alpha/beta
Protein Ontology	PR:000013365	proteasome subunit alpha type-6

References

(Earliest) J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)