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Psma6 Gene Detail
Summary
  • Symbol
    Psma6
  • Name
    proteasome (prosome, macropain) subunit, alpha type 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347006
    NCBI Gene: 26443
  • Gene Overview
    MyGene.info: PSMA6
Location & Maps
more
  • Sequence Map
    Chr12:55384222-55418454 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34233 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    PSMA6, proteasome subunit alpha 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PSMA6, proteasome subunit alpha 6
    Orthology source: HomoloGene
  • Synonyms
    IOTA, p27K, PROS27
  • Links
    NCBI Gene ID: 5687
    neXtProt AC: NX_P60900

  • Chr Location
    14q13; chr14:35278558-35317479 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2085
    1 human;1 mouse;1 rat;1 chimpanzee;2 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PSMA6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PSMA6 associations

Human Disease Mouse Models
       Myocardial Infarction, Susceptibility to   OMIM: 608446
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    59
  • Chemically induced (other)
    1
  • Gene trapped
    55
  • Targeted
    3
  • Genomic Mutations
    1 involving Psma6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034926 VEGA Gene Model | MGI Sequence Detail 34233 C57BL/6J ±  kb
transcript OTTMUST00000088808 VEGA | MGI Sequence Detail 1042 Not Applicable  
polypeptide OTTMUSP00000048451 VEGA | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    190 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 240
    cDNA 240

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
  • Latest
    J:196249 Lukic Z, et al., TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011;8:93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory