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Psma6
Gene Detail
Symbol

Name
ID
Psma6
proteasome (prosome, macropain) subunit, alpha type 6
MGI:1347006
Feature Type
protein coding gene
Genetic Map
Chromosome 12
23.94 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:55384222-55418454 bp, + strand
From VEGA annotation of GRCm38

  34233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Psma6

Human
homologs
Human Homolog PSMA6, proteasome (prosome, macropain) subunit, alpha type, 6
NCBI Gene ID 5687
neXtProt AC  NX_P60900
Human Synonyms  IOTA, p27K, PROS27
Human Chr (Location)  14q13; chr14:35278558-35317479 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PSMA6
Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(55) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Psma6 interacts with 191 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process positive regulation of NF-kappaB transcription factor activity, proteolysis, ...
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(240)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(240) cDNA(240)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034926 (Evidence)
Ensembl Gene ModelENSMUSG00000021024 (Evidence)
Entrez Gene26443 (Evidence)
UniGene30210
DFCITC1573083, TC1640008, TC1703727
DoTSDT.101252851, DT.110947990, DT.537106, DT.94242524, DT.94242526, DT.99863779
NIA Mouse Gene IndexU013964
EC3.4.25.1
PDB3UNB, 3UNE, 3UNF, 3UNH
Consensus CDS ProjectCCDS25917.1
International Mouse Knockout Project StatusPsma6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034926 VEGA Gene Model | MGI Sequence Detail 34233 C57BL/6J ±  kb
transcript OTTMUST00000088808 VEGA | MGI Sequence Detail 1042 Not Applicable 
polypeptide OTTMUSP00000048451 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000426 Proteasome, alpha-subunit, N-terminal domain
InterPro IPR023332 Proteasome A-type subunit
InterPro IPR001353 Proteasome, subunit alpha/beta
Protein Ontology PR:000013365 proteasome subunit alpha type-6
References
(Earliest) J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
(Latest) J:196249 Lukic Z, et al., TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions. Retrovirology. 2011;8:93
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory